-
摘要: 目的:探讨普罗布考对高血压患者血清血红素氧合酶1(HO-1)水平的影响和意义。方法:筛选40例原发性高血压患者,随机分为两组,分别接受以下药物治疗:苯磺酸左旋氨氯地平2.5mg/d+贝那普利10mg/d(对照组,20例),苯磺酸左旋氨氯地平2.5mg/d+贝那普利10mg/d+普罗布考组500mg/d(实验组,20例);同时入选健康体检者作为健康组(20例),随访4周。采用酶联免疫吸附法(ELISA)测定血清中HO-1的水平,观察比较3组血压、血脂和肝肾功能。结果:实验组和对照组血清HO-1水平明显高于健康组(P<0.05);与对照组相比,实验组TC、LDL-C及HDL-C明显降低(P<0.05);治疗后实验组及对照组血清HO-1水平下降,实验组下降更明显。结论:高血压患者血清HO-1水平显著升高,而普罗布考治疗可以改善高血压患者氧化应激状态,下调其血清HO-1水平,更有助于血压控制。Abstract: Objective:To observe the therapeutical effect of probucol on serum heme oxygenase-1(HO-1) in patients with primary hypertension. Method:A randomized study was performed on 40 patients with hypertension.The patients were randomly divided into control group(levamlodipine besylate 2.5 mg/d and benazepril 10 mg/d,n=20) or probucol group(levamlodipine besylate 2.5 mg/d and benazepril 10 mg/d and probucol 500 mg/d,n=20).And 20 healthy people were enrolled in the study.All subjects were followed up for 4 weeks.The levels of serum HO-1 were detected by ELISA method and other indexes including blood pressure,lipids and hepatic/renal function were measured after 4 weeks. Result:The levels of serum HO-1 in hypertension patients were higher than healthy people.Compared with control group,the levels of TC,LDL-C and HDL-C were lower in probucol group.The HO-1 levels in control and probucol group all decreased,the latter decreased more obviously. Conclusion:Hypertension patients have an increased levels of serum HO-1.The treatment of probucol can improve oxidative stress in hypertension patients and reduced serum HO-1 levels,which contributed to more antihypertensive effects.
-
Key words:
- primary hypertension /
- oxidative stress /
- heme oxygenase-1 /
- probucol
-
-
[1] ZHANG B,KANG M,XIE Q,et al.Anthocyanins from Chinese bayberry extract protectβ cells from oxidative stress-mediated injury via HO-1upregulation[J].J Agric Food Chem,2011,59:537-545.
[2] MADAMANCHI N R,VENDROV A,RUNGE M S.Oxidative stress and vascular disease[J].Arterioscler Thromb Vasc Biol,2005,25:29-38.
[3] SHEFTEL A D,KIM S F,PONKA P.Non-heme induction of heme oxygenase-1does not alter cellular iron metabolism[J].J Biol Chem,2007,282:10480-10486.
[4] SATO T,TAKENO M,HONMA K,et al.Heme oxygenase-1,apotential biomarker of chronic silicosis,attenuates silica-induced lung injury[J].Am J Respir Crit Care Med,2006,174:906-914.
[5] LIN Q,WEIS S,YANG G,et al.Heme oxygenase-1 protein localizes to the nucleus and activate transcription factors important in oxidative stress[J].J Biol Chem,2007,282:20621-20633.
[6] ZHOU S X,ZHOU Y,ZHANG Y L,et al.Antioxidant probucol attenuates myocardial oxidative stress and collagen expressions in post-myocardial infarction rats[J].J Cardiovasc Pharmacol,2009,54:154-162.
[7] 王哲,马铁,杨向红.普罗布考和辛伐他汀对高级糖基化终末产物诱导的大鼠肾脏微血管内皮细胞的ROS含量和HO-1表达影响[J].中国病理生理杂志,2010,26(9):1749-1752.
[8] HONG S C,ZHAO S P,WU Z H.Effect of probucol on HDL metabolism and class B type I scavenger receptor(SR-BI)expression in the liver of hyper cholesterolemic rabbits[J].Int J Cardiol,2007,115:29-35.
-
计量
- 文章访问数: 71
- PDF下载数: 82
- 施引文献: 0
下载: