红细胞膜总胆固醇含量与急性冠状动脉综合征的相关性

余梅玫; 徐岩

doi:10.13201/j.issn.1001-1439.2012.07.009

红细胞膜总胆固醇含量与急性冠状动脉综合征的相关性

余梅玫^1, ,,
徐岩²

- 1. 合肥市滨湖医院急诊科(合肥, 230061);
- 2. 安徽医科大学第一附属医院心内科

详细信息

通讯作者: 余梅玫,E-mail:ahymm@yahoo.cn

中图分类号: R541.4

收稿日期: 2011-11-20

修回日期: 2012-01-15

Relationship between total cholesterol content of erythrocyte membranes and acute coronary syndrome

YU Meimei^1, ,,
XU Yan²

- 1. Department of Emergency, Binhu Hospital of Hefei City, Hefei, 230061, China;
- 2. Department of Cardiology, the First Affiliated Hospital of Anhui Medical University

More Information

Corresponding author: YU Meimei, E-mail: ahymm@yahoo.cn

Received Date: 20 November 2011

Revised Date: 15 January 2012

摘要

摘要: 目的:研究红细胞膜总胆固醇含量(CEM)与急性冠状动脉综合征(ACS)的相关性。方法:204例胸痛患者行冠状动脉造影后分成ACS组98例,稳定型心绞痛(SAP)组45例和对照组61例。采用酶学的方法测定各组CEM水平,用ELISA法测定血清高敏C反应蛋白(hs-CRP)水平。结果:ACS组CEM值为(149.50μg/mg,120.33~180.11μg/mg),较SAP组(79.98μg/mg,56.75~97.56μg/mg)及对照组(76.64μg/mg,62.12~91.84μg/mg)均明显增高(均P<0.05)。多因素逻辑回归分析提示CEM与ACS发病显著相关(OR 24.990,95%CI5.220~119.596,P<0.01)。CEM水平与血清hs-CRP呈显著正相关(r=0.328,P<0.01)。结论:CEM可能通过炎症反应参与ACS发病的进程,是动脉粥样易损斑块的一个潜在标记物,对于ACS的预测作用优于hs-CRP。
- 急性冠状动脉综合征 /
- 红细胞膜总胆固醇含量 /
- 易损斑块 /
- 血清高敏C反应蛋白
Abstract: Objective:To study the relationship between total cholesterol content of erythrocyte membranes(CEM) and acute coronary syndrome(ACS). Method:The 204 subjects with the main complaint of chest pain underwent coronary artery angiography were divided into 3 groups,including ACS(n=98),stable angina pectoris(SAP)(n=45) and control groups(n=61).CEM levels were measured by enzymatic assay.Serum high sensitivity C-reactive protein(hs-CRP) levels were measured by ELISA. Result:CEM levels in the ACS group were significantly higher(149.50 μg/mg,range 120.33 to 180.11 μg/mg) than the SAP group(79.98 μg/mg,range 56.75 to 97.56 μg/mg) and control group(76.64 μg/mg,range 62.12 to 91.84 μg/mg).Multivariable Logistic regression analyses revealed a significant independent relation between CEM levels and ACS(OR 24.990,95%CI 5.220 to 119.596,P<0.01).We also found CEM levels were positively correlated with serum hs-CRP(r=0.328,P<0.01). Conclusion:CEM may be involved in the pathogenic progression of ACS through inflammation and is a marker of vulnerable atheromatous plaque.CEM is Superior to hs-CRP as a predictor to ACS.
- acute coronary syndromes /
- total cholesterol content of erythrocyte membranes /
- vulnerable plaque /
- serum high sensitivity C-reactive protein

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