冠心病患者血浆白细胞介素-35水平及临床意义的探讨

台适; 周胜华; 刘启明; 胡信群; 方臻飞; 唐亮

doi:10.13201/j.issn.1001-1439.2014.01.025

冠心病患者血浆白细胞介素-35水平及临床意义的探讨

- 中南大学湘雅二医院心内科(长沙, 410011)

详细信息

通讯作者: 周胜华, E-mail:zhoushenghua_guo@163.com

中图分类号: R541.4

收稿日期: 2013-07-29

The plasma IL-35 levels in patients with coronary heart disease and its clinical significance

- Department of Cardiology, the Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China

More Information

Corresponding author: ZHOU Shenghua, E-mail: zhoushenghua_guo@163.com

Received Date: 29 July 2013

摘要

- 冠心病 /
- 白细胞介素-35 /
- 高敏C反应蛋白 /
- N末端脑钠肽前体 /
- 动脉粥样硬化
Abstract: This study was designed to observe the change of the plasma IL-35 levels in patients with different type of coronary heart disease (CHD) and analyzed its correlation with coronary gensini score, high-sensitive Creactive protein (hs-CRP) and NT-proBNP.The results showed that plasma IL-35 levels were significantly decreased in the SAP group, the UAP group, and the AMI group compared with the patients in control group[(95.71±4.05) vs (111.44±4.57), P<0.001; (45.00±3.18) vs (111.44±4.57), P<0.001; (28.25±3.19) vs (111.44±4.57), P<0.001, respectively].Furthermore, lower IL-35levels were moderately negatively correlated with NT-proBNP (r=-0.567, P<0.01) and hs-CRP (r=-0.718, P<0.01) in CHD patients, whereas the levels of IL-35were not related to the Gensini score.
- coronary disease /
- interleukin-35 /
- high sensitive-C reaction protein /
- NT-proBNP /
- atherosclerosis

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参考文献(17)

[1]	FROSTEGARD J, ULFGREN A K, NYBERG P, et al.Cytokine expression in advanced human atherosclerotic plaques:dominance of pro-inflammatory (Th1) and macrophage-stimulating cytokines[J].Atherosclerosis, 1999, 145:33-43.
[2]	ALAM S E, NASSER S S, FERNAINY K E, et al.Cytokine imbalance in acute coronary syndrome[J].Curr Opin Pharmacol, 2004, 4:166-170.
[3]	TEDGUI A, MALLAT Z.Cytokines in atherosclerosis:pathogenic and regulatory pathways[J].Physiol Rev, 2006, 86:515-581.
[4]	NIEDBALA W, WEI X Q, CAI B, et al.IL-35is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells[J].Eur J Immunol, 2007, 37:3021-3029.
[5]	COLLISON L W, WORKMAN C J, KUO T T, et al.The inhibitory cytokine IL-35contributes to regulatory T-cell function[J].Nature, 2007, 450:566-569.
[6]	LI X, MAI J, VIRTUE A, et al.IL-35is a novel responsive anti-inflammatory cytokine——a new system of categorizing anti-inflammatory cytokines[J].PLoS One, 2012, 7:e33628-33628.
[7]	KOCHETKOVA I, GOLDEN S, HOLDERNESS K, et al.IL-35stimulation of CD39+ regulatory T cells confers protection against collagenⅡ-induced arthritis via the production of IL-10[J].J Immunol, 2010, 184:7144-7153.
[8]	KEMPE S, HEINZ P, KOKAI E, et al.Epstein-barr virus-induced gene-3is expressed in human atheroma plaques[J].Am J Pathol, 2009, 175:440-447.
[9]	GENSINI G G.A more meaningful scoring system for determining the severity of coronary heart disease[J].Am J Cardiol, 1983, 51:606-608.
[10]	LEE T S, YEN H C, PAN C C, et al.The role of interleukin 12in the development of atherosclerosis in ApoE-deficient mice[J].Arterioscler Thromb Vasc Biol, 1999, 19:734-742.
[11]	CAO Y, DOODES P D, GLANT T T, et al.IL-27 induces a Th1 immune response and susceptibility to experimental arthritis[J].J Immunol, 2008, 180:922-930.
[12]	TASSI E, BRAGA M, LONGHI R, et al.Non-redundant role for IL-12and IL-27in modulating Th2 polarization of carcinoembryonic antigen specific CD4 T cells from pancreatic cancer patients[J].PLoS One, 2009, 4:e7234-7234.
[13]	BICKERSTAFF A, OROSZ C.Evidence for a limited contribution of immune regulation to cardiac allograft acceptance[J].Hum Immunol, 2002, 63:935-947.
[14]	FEINBERG M W, JAIN M K, WERNER F, et al.Transforming growth factor-beta 1inhibits cytokinemediated induction of human metalloelastase in macrophages[J].J Biol Chem, 2000, 275:25766-25773.
[15]	张文宗, 林钟香.转化生长因子-β1在冠心病中的研究进展[J].实用医学杂志, 2008, 7 (21):3779-3781.
[16]	LINDMARK E, TENNO T, CHEN J, et al.IL-10inhibits LPS-induced human monocyte tissue factor expression in whole blood[J].Br J Haematol, 1998, 102:597-604.
[17]	LIN Y, HUANG Y, LU Z, et al.Decreased plasma IL-35levels are related to the left ventricular ejection fraction in coronary artery diseases[J].PLoS One, 2012, 7:e52490-52490.