Abstract: Objective: To observe the nickel serum concentrations changes in patients with congenital heat disease after transcatheter closure and research the relationship between nickel serum concentrations and inflammatory factor (IL-6, IL-10) in patients with congenital heat disease after transcatheter closure.Method: All 30patients with congenital heart disease including atrial septal defect (ASD) and ventricle septal defect (VSD) underwent transcatheter closure and 30 healthy control subjects (NC group) were selected for the study.Blood samples for analysis were collected from the patients before the closure and 24h, 1 month, 3 month, and 6 month after the closure respectively.Nickel serum concentrations and IL-6, IL-10were assayed.Result: ①Mean baseline nickel serum concentrations were within normal range.After occluder implantation, nickel serum concentrations increased over the first month and then decreased to preimplantation levels within 3-6 months.The nickel serum concentrations after occluder implantation was 3-fold higher than baseline (P＜0.05).②Before transcatheter closure, the IL-6, IL-10 was significant higher than those in NC group (P﹤0.05).After occluder implantation, IL-6increased over the first month and then decreased to NC group levels within 3-6 months.③The relationship between nickel serum concentrations and IL-6, IL-10was linear correlation in 1month after occluder implantation.Conclusion: After occluder implantation, nickel serum concentrations increase over the first month and then decrease to preimplantation levels within 3-6 months.Mean baseline nickel serum concentrations are within normal range.Nickel serum concentrations and immunity activation condition is linear correlation in 1month after occluder implantation.