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摘要: 目的:研究膜突蛋白 (Moesin) 抗体在急性冠状动脉综合征 (ACS) 中的表达情况, 并对患者进行全球急性冠状动脉综合征注册 (GRACE) 评分, 探讨Moesin抗体、GRACE评分与ACS之间的相关性。方法:选择126例ACS患者, 根据冠状动脉造影结果分为单支病变、双支病变、3支病变或左主干病变3组。对其进行GRACE评分, 同期选取非冠心病者41例作为对照组。采用酶联免疫吸附试验 (ELISA) 检测入选者血清Moesin抗体, 观察其Moesin抗体阳性检出率及OD检测值, 并对Moesin抗体的OD检测值与GRACE评分进行相关性分析。结果:①ACS患者的Moesin抗体阳性检出率及OD检测值显著高于对照组 (P＜0.01);并随着冠状动脉病变程度的加重, GRACE评分逐渐升高, Moesin抗体阳性检出率及OD检测值也逐渐升高, 其中3支病变及左主干病变组与单支病变组比较有显著差异 (P＜0.05);②相关性分析显示, Moesin抗体的OD检测值与GRACE评分呈显著性正相关 (r=0.452, P＜0.05)。结论:Moesin抗体可能是判断ACS患者风险程度和血管病变程度的一种新的评估指标。Moesin抗体与GRACE评分在ACS中呈正相关。
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关键词:
- 急性冠状动脉综合征 /
- 膜突蛋白抗体 /
- 全球急性冠脉综合征注册评分
Abstract: Objective: To investigate the acute coronary syndrome (ACS) correlation with membrane protein (Moesin) antibody, the Global Registry of Acute Coronary Events (GRACE) by detecting the serum levels of anti Moesin antibody in patients with ACS.Method: We selected 126 patients with ACS and divided them into singlevessel group, the double-vessel group and three-vessel and left main vessel group according to the results of the coronary angiography.Then we calculated the GRACE risk scores.In the same period, 41 patients excluded coronary heart disease served as control group.We detected serum anti moesin antibody of the patients by enzymelinked immunosorbent assay (ELISA) and observed the anti Moesin antibody positive expression rate and OD value.Result: ①In 126 patients with ACS, the positive detectable rate and OD detection value of moesin antibody were significantly higher than those in the control group (P＜0.01);With the coronary artery lesions getting severe, the GRACE risk scores also gradually rise, the positive detectable rate and OD detection value of Moesin antibody were gradually increasing, and there was significant difference between three-vessel and left main vessel group and single-vessel group (P＜0.05), while other two groups had no such differences (P＞0.05).②Correlation analysis showed that there was significantly positive correlation between the OD detction value of anti moesin antibody and the GRACE risk scores (r=0.452, P＜0.05).Conclusion: The moesin antibody can be used as a new evaluation index to judge the coronary artery lesion severity of the ACS patients.Moesin antibody with GRACE score is positively correlation in ACS.-
Key words:
- acute coronary syndrome /
- moesin antibody /
- GRACE
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