可达龙联合琥珀酸美托洛尔缓释片对植入埋藏式自动心脏复律除颤器的致死性室性心律失常患者的疗效观察

黄瑞娜; 吴铿; 叶少强; 李上海; 游琼; 闫海; 郑锡锋

doi:10.13201/j.issn.1001-1439.2014.07.019

可达龙联合琥珀酸美托洛尔缓释片对植入埋藏式自动心脏复律除颤器的致死性室性心律失常患者的疗效观察

- 广东医学院附属医院心内科(广州湛江, 524001)

详细信息

通讯作者: 吴铿,E-mail:wukeng1245@hotmail.com

中图分类号: R541.7

收稿日期: 2013-10-01

Efect of Cordarone jointing Metoprolol succinate tablets in patients with lethal ventricular arrhythmias who have implanted automatic implantable cardioverter defibrillator

- Department of Cardiology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, 524001, China

More Information

Corresponding author: WU Keng, E-mail: wukeng1245@hotmail.com

Received Date: 01 October 2013

摘要

摘要: 目的:评估可达龙联合琥珀酸美托洛尔缓释片对植入埋藏式自动心脏复律除颤器 (ICD) 治疗致死性室性心律失常的疗效。方法:选取我院2006-01-2012-07室性致死性心律失常患者43例, 行ICD置入术, 术后随机分为对照组 (可达龙) 20例与治疗组 (可达龙联合琥珀酸美托洛尔缓释片) 23例, 随访6个月, 比较两者临床事件发生率、起搏器程控参数和超声心动图指标等。结果:所有患者随访期间未出现晕厥及猝死。治疗组临床事件、心律失常事件发生率低于对照组, 而且LAD、LVEDD、E/A得以改善。两组患者心室电极导线感知、起搏阈值、阻抗、除颤阈值与用药前比较无变化。结论:可达龙联合琥珀酸美托洛尔缓释片治疗因致死性室性心律失常植入ICD患者的疗效优于单用可达龙。
- 室性心律失常 /
- 埋藏式自动心脏复律除颤器 /
- 可达龙 /
- 琥珀酸美托洛尔缓释片
Abstract: Objective: To obsever the effect and safty of automatic implantable cardioverter defibrillator combination with Cordarone and Metoprolol succinate tablets on lethal ventricular arrhythmias.Method: All 43 patients with fatal ventricular arrhythmias, who had implanted automatic implantable cardioverter defibrillator in our hospital from January 2006 to July 2012, were randomly divided into control group (n=20) and treatment group (n=23).Control group was treated with Cordarone, and treatment group was treated with Cordarone jointing Metoprolol succinate tablets.Two groups were followed for 6months to compared the incidence of clinical events, the pacemaker programmed parameters and color Doppler index.Result: All patients had no syncope or sudden death during follow-up.Compared with control group, treatment group's incidence of clinical events and arrhythmic events decreased morely, and LAD, LVEDD and E/A improved morely.Two groups of patients had no significant change about ventricular electrode perception, threshold, impedance and defibrillation thresholds before or after treatment.Conclusion: It is effective and safe for automatic implantable cardioverter defibrillator combination with Cordarone and Metoprolol succinate tablets on lethal ventricular arrhythmias.
- ventricular arrhythmias /
- automatic implantable cardioverter defibrillator /
- Cordarone /
- Metoprolol succinate tablets

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参考文献(9)

[1]	《中国心脏起搏与心电生理杂志》编辑部, 中国生物医学工程学会心脏起搏与电生理分会.埋藏心脏起搏及抗心律失常器指南 (修订版)[J].中国心脏起搏与心电生理杂志, 2003, 17 (5):321-338.
[2]	赵玲, 郭涛, 韩明华, 等.16例置入埋藏式心脏复律除颤器的术后随访[J].中国心脏起搏与心电生理杂志, 2003, 17 (5):358-360.
[3]	刘杰, 胡大一.抗心律失常药物在埋藏式心脏复律除颤器患者中的应用[J].中国心脏起搏与心电生理杂志, 2002, 16 (5):379-383.
[4]	刘小珍, 杨友星.美托洛尔缓释片治疗原发性高血压并舒张性心力衰竭的疗效观察[J].当代医学, 2011, 17 (6):140-141.
[5]	HUNT S A, BAKE D W, CHIN M H, et al.ACC/AHA guidelines for the eval-uation and management of chormic heart failure in the adult:executive summary.A report of the American College of Cardio-logy/A merican Heart Association Task Force on Practice Guidel-ines (Committee to revise the 1995 Guiddines for the Evaluati-on and Management of Heart Failure)[J].J Am Coil Cardiol, 2001, 38:2101-2113.
[6]	张楠, 郭继鸿.抗心律失常药物对心脏起搏阈值的影响[J].中华心律失常学杂志2006, 10 (5):389-391.
[7]	MASSIMO S.CARLO P, RENATO R, et al.Efectiveness of ibutilide in cardioversion of persistent atrial fibrillation in patients with dual chamber stimulation[J].J Interv Car Electrophysio1, 2003, 9:15-20.
[8]	MOVSUWITZ C, MARCHLINSKI F E.Interactions between implantable cardioverter-defibrillators and ClassⅢagents[J].Am J Cardiol, 1998, 82:411-411.
[9]	KUBLKAMP V, MEWIS C, SUCHALLA R, et al.Effect of amiodarone and sotalol on the defibrillation threshold in comparison to patients without antiarrhythmic drug treatment[J].Int J Cardiol, 1999, 69:271-271.