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摘要: 冠心病是危害人类健康的疾病,近几十年来其发病率和病死率呈上升趋势。再灌注治疗是挽救心肌梗死的有效手段,同时也可能对心脏产生更大的损伤,即心肌缺血再灌注损伤(myocardial ischemia reperfusion injury,MIRI)。大量研究表明,ATF/CERB家族成员ATF3在缺血再灌注损伤中发挥负性调控作用。本文将对ATF3的表达特点和其在MIRI中的负性调控作用进行综述。这将为ATF3过表达治疗MIRI这一基因治疗策略提供理论基础。Abstract: Coronary heart disease (CHD) is a disorder that endangers human health, which appears to rise in morbidity and mortality in recent decades. Reperfusion therapies are the effective strategies to rescue infracted myocardium, at the same time, these means of ischemia reperfusion may lead more serious injure in heart, which is called myocardial ischemia reperfusion injury (MIRI). Scores of researches demonstrated that ATF/CREB family member ATF3 developed a negative regulation in ischemia reperfusion injury (IRI). This review will expound the expression characteristic of ATF3 and its negative regulation in MIRI. Here, we may provide a theoretical basis that over expression ATF3 in myocardium is a promising gene therapeutic strategy in MIRI.
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