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摘要: 目的:探讨血浆内皮素1(ET-1)、Toll样受体4(TLR-4)与冠状动脉慢血流的关系。方法:入选2014-01-2015-07于本院行冠状动脉造影的39例冠状动脉慢血流患者为试验组,同期冠状动脉造影正常的40例患者为对照组,采用酶联免疫吸附法(ELISA)测定两组患者血浆ET-1、TLR-4水平。结果:两组平均血流帧数的差异有统计学意义(P<0.001);冠状动脉慢血流患者中男性比例(79%)远大于女性;两组平均红细胞血红蛋白浓度(MCHC)、红细胞分布宽度变异系数(RDW-CV)、ET-1、TLR-4之间的差异有统计学意义(均P＜0.05),其他实验室指标的差异无统计学意义。多因素logistic回归分析示ET-1、TLR-4与冠状动脉慢血流独立相关(均P＜0.05);ET-1与TLR-4的Spearman相关系数为0.439(P<0.001),TLR-4与MCHC的Spearman相关系数为0.277(P=0.014),提示TLR-4与ET-1、MCHC显著相关,但相关关系并不密切(r<0.5)。结论:ET-1、TLR-4以及红细胞变形可能参与了冠状动脉慢血流的发生、发展。Abstract: Objective:To analyze the relationship between plasma ET-1, TLR-4 and coronary slow flow (CSF).Method:From January 2014 to July 2015, 79 patients with angiographically proved stenosis less than 40% were divided into CSF group (n=39) and control group (n=40). The concentrations of plasma ET-1 and TLR-4 were determined by using ELISA.Result:The frame counts between 2 groups were significant different (P<0.001). In CSF group, the proportion of males (79%) was higher than females. There was significant difference in MCHC, RDW-CV, ET-1, TLR-4 between two groups (P<0.05). Multiple logostic regression analysis showed that ET-1, TLR-4 were independently associated with CSF (P<0.05). The plasma level of TLR-4 was positively related to plasma ET-1 (r=0.439, P<0.001) and MCHC (r=0.277,P=0.014), but the corrections were weak (r<0.5).Conclusion:ET-1, TLR-4 and RBC deformability may play some pathophysiologic roles in CSF.
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Key words:
- coronary slow flow /
- Endothelin-1 /
- Toll-like receptor-4 /
- red blood cell
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