Safety and efficacy of paclitaxel-eluting stents versus sirolimus-eluting stents in diabetes patients undergoing percutaneous coronary intervention:A Meta analysis
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摘要: 目的:比较紫杉醇洗脱支架(PES)与西罗莫司洗脱支架(SES)在糖尿病患者冠状动脉介入治疗中的有效性和安全性。方法:通过Medline、EMBASE、Cochrane library数据库检索2016年5月之前所有相关英文临床随机对照试验(RCTs)。两名评价者利用Jadad评分量表独立评价纳入RCTs的质量并提取资料,评估全因死亡率、支架血栓形成(ST)率及靶病变血运重建(TLR)、靶血管血运重建(TVR)、心肌梗死(MI)、主要不良心脏事件(MACE)发生率,并用Review Manager 5.3软件进行统计分析。结果:最终分析数据来源于9个RCT试验。SES组与PES组全因死亡率、ST率以及MI发生率无统计学差异,但SES组TLR、TVR率以及MACE发生率明显优于PES组(均P<0.05)。结论:从目前临床研究看,对于糖尿病患者,SES的安全性和有效性优于PES。Abstract: Objective:To investigate the safety and efficacy of paclitaxel-eluting stents(PES)versus sirolimuseluting stents(SES)in diabetes patients undergoing percutaneous coronary intervention(PCI).Method:We systematically searched the literature through the MEDLINE,Cochrane library,and EMBASE database.Quality assessments were evaluated with Jadad quality scale.Outcomes content the rate of all-cause mortality,stent thrombosis(ST),target lesion revascularization(TLR),target vessel revascularization(TVR),myocardial infarction(MI),major adverse cardiac events(MACE).All statistical analyses were performed using Review Manager 5.3.Result:Nine RCTs satisfying the inclusion criteria were finally analyzed.There was no significant difference in allcause mortality,ST and MI.Whereas there was a significant decrease of TLR,TVR,MACE.Conclusion:From the current clinical research,the safety and efficacy of SES is better than PES in diabetes patients undergoing PCI.
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Key words:
- paclitaxel /
- sirolimus /
- eluting stent /
- diabetes mellitus /
- Meta-analysis
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