经皮肾动脉去交感神经术在慢性收缩性心力衰竭患者中的应用研究

郜俊清; 杨伟; 刘宗军

doi:10.13201/j.issn.1001-1439.2016.10.009

经皮肾动脉去交感神经术在慢性收缩性心力衰竭患者中的应用研究

- 上海市普陀区中心医院心内科(上海, 200333)
基金项目:
国家自然科学基金青年项目资助(No:81303145)

上海市卫计委重点项目(No:20134003)

上海市卫计委面上项目(No:201440492)

上海市卫计委医学重点专科建设项目(No:ZK2015A17)

详细信息

通讯作者: 刘宗军,E-mail:95885209@qq.com

中图分类号: R541.6

收稿日期: 2016-04-16

修回日期: 2016-07-02

Application of percutaneous renal artery denervation in patients with chronic systolic heart failure

- Department of Cardiology, Central Hospital of Shanghai Putuo District, Shanghai, 200333, China

More Information

Corresponding author: LIU Zongjun, E-mail: 95885209@qq.com

Received Date: 16 April 2016

Revised Date: 02 July 2016

摘要

摘要: 目的:研究经皮肾动脉去交感神经术(RDN)对慢性收缩性心力衰竭患者心功能改善的作用。方法:将60例慢性收缩性心力衰竭患者分为2组,其中RDN组接受双侧肾动脉去神经治疗,对照组仅接受药物治疗。对所有的患者进行6个月的随访,观察N末端脑钠肽前体(NT-pro BNP)、6min步行距离、心功能、血压及生化指标的变化。结果:6个月随访时,与对照组比较,RDN组左室射血分数(LVEF)显著提高[(39.1±7.3)%:(35.6±3.3)%,P<0.05],NT-proBNP显著下降[(440.1±226.5)pg/ml:(790.8±287.0)pg/ml,P<0.05],6min钟步行距离显著提高[(301.2±139.5)m:(227.2±65.0)m,P<0.05],血压显著下降[(123.3±68.5)mmHg:(139.8±80.2)mmHg,P<0.05]。结论:RDN可能是一种有效的治疗慢性心力衰竭的新技术,可有效提高患者LVEF,改善心功能,提高运动耐量。
- 肾去神经化 /
- 交感神经系统 /
- 心力衰竭 /
- 血压
Abstract: Objective:To study the effect of percutaneous renal artery denervation(RDN)on cardiac function in patients with chronic systolic heart failure(CHF).Method:Sixty patients with CHF were divided into 2groups,the patients in RDN group were treated with bilateral renal artery denervation,while the patients in control group received drug treatment.All the patients were follow-up for 6 months,and NT-pro BNP,6 minutes walking distance,cardiac function,blood pressure and biochemical examination were observed.Result:After 6months of follow-up,the RDN group showed that,the left ventricular ejection fraction(LVEF)significantly increased[(39.1±7.3)% vs(35.6±3.3)%,P<0.05],the NT-proBNP significantly decreased[(440.1±226.5)pg/ml vs(790.8±287.0)pg/ml,P<0.05],the 6min walking distance significantly increased[(301.2±139.5)m vs(227.2±65.0)m,P<0.05],and the blood pressure decreased significantly[(123.3±68.5)mmHg:(139.8±80.2)mmHg,P<0.05].Conclusion:RDN can effectively improve the cardiac function,improve cardiac function and exercise tolerance in patients with CHF.RDN may be an effective treatment for CHF.
- renal denervation /
- sympathetic nervous system /
- heart failure /
- blood pressure

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