The relationship between echocardiography parmeters and NT-proBNP level in atrial fibrillation patients with diastolic dysfunction
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摘要: 目的:探讨超声心动图各参数指标与N末端脑钠肽前体(NT-proBNP)在舒张功能不全的心房颤动(房颤)患者中的变化及其相关性。方法:选取舒张功能不全的房颤患者204例,分为阵发性房颤组87例,持续性房颤组117例(包含长期持续性和永久性房颤),另选取收治入院的100例不伴有房颤的舒张功能不全患者作为对照组,收集所有入选对象的超声心动图参数及NT-proBNP水平,并探讨其相关性。结果:房颤组患者的左心房内径、左心房容积指数、NT-proBNP均高于对照组,差异有统计学意义(P＜0.05),且持续性房颤组与阵发性房颤组同样有统计学差异(P＜0.05)。相关性分析显示,NT-proBNP与左心房内径(r=0.626,P＜0.001)、左心房容积指数(r=0.470,P=0.001)呈正相关。结论:舒张功能不全的房颤患者左心房明显增大,NT-proBNP水平明显增高且与左心房内径、左心房容积指数相关。Abstract: Objective: To explore the changes of echocardiography parmeters and NT-proBNP level and their relationship in atrial fibrillation patients with diastolic dysfunction. Method: A consecutive of 204 patients diagnosed as atrial fibrillation (87 paroxysmal cases and 117 persistent cases) with diastolic dysfunction were enrolled. 100 in-hospital diastolic dysfunction patients without atrial fibrillation were regarded as the control group. The data of echocardiography parmeters and NT-proBNP lev were collected and the correlation analysis was made. Result: The level of left atrial dimension, left atrial volume index and NT-proBNP in the atrial fibrillation groups were significantly higher than those in the control group(P＜0.05). There was also statistically significance between the paroxysmal and persistent sub-groups(P＜0.05). The correlation analysis showed that NT-proBNP level was correlated with left atrial dimension (r=0.626,P＜0.001)and left atrial volume index(r=0.470,P=0.001).Conslusion: In atrial fibrillation patients with diastolic dysfunction, the left atrial is obviously expanded. The NT-proBNP level is largely increased and correlated with left atrial dimension and left atrial volume index.
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Key words:
- atrial fibrillation /
- echocardiography /
- NT-proBNP
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