Effects of trimetazidine on coronary slow flow in cardiac syndrome X complicated with type 2 diabetes
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摘要: 目的:研究曲美他嗪对心脏X综合征合并2型糖尿病患者冠状动脉慢血流的治疗作用。方法:将87例心脏X综合征合并2型糖尿病冠状动脉造影时出现慢血流的患者随机分为曲美他嗪组(45例)和对照组(42例)。对照组采用拜阿司匹林100 mg/d、单硝酸异山梨酯20 mg/d、阿托伐他汀20 mg/d联合严格控制血糖治疗,曲美他嗪组在此基础上加用曲美他嗪20 mg/次,3次/d,连续治疗6个月。观察治疗前后两组患者冠状动脉TIMI血流分级和冠状动脉血流储备的变化。结果:6个月治疗结束后,曲美他嗪及对照组冠状动脉血流储备值较治疗前均有明显提高(P＜0.05),且曲美他嗪组提高幅度显著高于对照组(P＜0.05)。曲美他嗪组冠状动脉TIMI血流改善的有效率也显著高于对照组(P＜0.05)。结论:长期曲美他嗪治疗可改善心脏X综合征合并糖尿病及冠状动脉慢血流患者的TIMI血流分级和冠状动脉血流储备功能。Abstract: Objective: To investigate the therapeutic effect of trimetazidine on coronary slow flow in cardiac syndrome X patients who complicating type 2 diabetes. Method: The 87 cases with coronary slow flow complicated with cardiac syndrome X and type 2 diabetes were randomly divided into trimetazidine group (45 cases) and control group (42 cases). Patients in control group were treated with aspirin (100 mg/d), isosorbide mononitrate(20 mg/d) and atorvastatin (20 mg/d), whereas patients in trimetazidine group received trimetazidine (20 mg, 3 times/day) in addition to the therapeutic regimen of control group. The changes of TIMI grade of coronary artery blood flow and coronary flow reserve (CFR) before and after 6 months of treatment in the two groups were measured. Result: After 6 months of treatment, the CFR values in both groups were significantly elevated compared with baseline value (P＜0.05). In addition, the CFR value in trimetazidine group was higher than that in control group. The improvement rate of TIMI grade of coronary artery blood flow in trimetazidine group was significantly higher than that in control group (P＜0.05). Conclusion: Long-term administration of trimetazidine in the cardiac syndrome X patients who complating type 2 diabetes and coronary slow flow may improve the TIMI grade of coronary artery blood flow and coronary flow reserve functon.
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Key words:
- coronary disease /
- coronary slow flow phenomenon /
- trimetazidine /
- coronary flow reserve
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