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摘要: 目的:研究慢性心力衰竭(CHF)与血尿酸(SUA)的关系,为云南地区CHF患者的防治提供新的科学依据。方法:回顾性研究CHF患者共计2 483例,分析其SUA水平与心功能级别、性别、年龄、B型脑钠肽(BNP)、左室射血分数(LVEF)、左室舒张末期内径(LVEDd)的关系。结果:CHF患者SUA增高,且SUA增高与心功能级别有关。高尿酸血症(HUA)患者SUA水平与心功能分级有关(P＜0.05),而SUA正常的患者其SUA水平与心功能级别无关。男性SUA水平明显高于女性。青年组SUA水平最高。SUA水平与心功能、LVEDd和BNP呈正相关,与LVEF呈负相关。结论:CHF患者的SUA水平与性别、年龄、心功能分级、BNP、LVEF、LVEDd相关,SUA可能是预测CHF预后的独立危险因素之一。Abstract: Objective: To explore the relationship between serum uric acid (SUA) and chronic heart failure(CHF) in Yunnan Province.Method: The clinical data of 2483patients with CHF were collected and the patients who missed serum uric acid (SUA) were excluded. The relationship between SUA level and cardiac function grade, gender, age, type B brain natriuretic peptide (BNP), left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDd) was investigated.Result: SUA levels of HUA group were increased with cardiac function deterioration(P＜0.05).The SUA level of the male was significantly higher than that in the female.The young men had higher SUA levels.SUA level was positively correlated with cardiac function, LVEDd and BNP, while negatively correlated with LVEF.Conclusion: The SUA level in patients with CHF are high in Yunnan Province, HUA could be an independent risk factor of CHF.
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Key words:
- serum uric acid /
- heart failure
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[1] 中国医师协会心血管内科医师分会,中国医师协会循证医学专业委员会.无症状高尿酸血症合并心血管疾病诊治建议中国专家共识[J].中国全科医学,2010,13(4B):1145-1149.
[2] 宋琴,颜雪芸,董艳梅.血清尿酸水平在慢性心力衰竭患者病程中的临床意义[J].中国心血管病研究,2014,12(9):819-821.
[3] 孔祥萦,沈洁,高蓉蓉,等.心力衰竭类型与肾功能的相关性研究[J].临床心血管病杂志,2014,30(6):509-512.
[4] HAMAGUCHI S,FURUMOTO T,TSUCHIHASHIMAKAYA M,et al.Hyperuricemia predicts adverse outcomes in patients with heart failure[J].Int J Cardiol,2011,151:143-147.
[5] OGINO K,KATO M,FURUSE Y,et al.Uricacidlowering treatment with benzbromarone in patients with heart failure:adouble-blind placebo-controlled crossover preliminary study[J].Circ Heart Fail,2010,3:73-81.
[6] HARZAND A,TAMARIZ L,HAREJM.Uric acid,heart failure survival,and the impact of xanthine oxidase inhibition[J].Congest Heart Fail,2012,18:179-182.
[7] LEYVA F,ANKERS,SWAN J W,et al.Serum uric acid as an index of impaired oxidative metabolism in chronic heart failure[J].Eur Heart J,1997,18:858-865.
[8] 吴君,邓根群,李永旺,等.慢性心力衰竭患者尿液肾损伤分子-1的检测及意义[J].临床心血管病杂志,2016,32(2):166-169.
[9] 熊轩,钟小仕,肖笑,等.广州市1 420名体检者高尿酸血症患病率及危险因素调查[J].中华全科医师杂志,2013,12(7):560-562.
[10] 王勇强,邓玉奎,林松,等.绝经期后女性血尿酸参考区间的建立及与雌激素相关性研究[J].标记免疫分析与临床,2014,21(3):249-250.
[11] 叶桃春,许顶立,沈倩波,等.慢性心力衰竭患者血尿酸水平与左室重构程度关系的探讨[J].临床心血管病杂志,2008,24(4):253-255.
[12] SAKAI H,TSUTAMOTO T,TSUTSUI T,et al.Serum level of uric acid,partly secreted from the failing heart,is a prognostic marker in patients with congestive heart failure[J].Circ J,2006,70:1006-1011.
[13] VADUGANATHAN M,GREENES J,AMBROSYAP,et al.Relation of serum uric acid levels and outcomes among patients hospitalized for worsening heart failure with reduced ejection fraction(from the efficacy of vasopressin antagonism in heart failure outcome study with tolvaptan trial)[J].Am J Cardiol,2014,114:1713-1721.
[14] BORGHI C,COSENTINO ER,RINALDI ER,et al.Uricaemia and ejection fraction in elderly heart failure outpatients[J].Eur J Clin Invest,2014,44:573-578.
[15] LEVY WC,MOZAFFARIAN D,LINKER DT,et al.The Seattle CHF mode:prediction of survival in CHF[J].Circulation,2006,113:1424-1433.
[16] MANZANO L,BABALIS D,ROUGHTON M,et al.Predictors of clinical outcomes in elderly patients with CHF[J].Euro J Heart Fail,2011,13:528-536.
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