扩张型心肌病不同心功能状态甲状腺激素水平变化及临床意义

梁琦; 殷艳蓉; 雷新军; 韩克; 黄欣; 任洁; 李红兵; 袁祖贻

doi:10.13201/j.issn.1001-1439.2017.02.006

扩张型心肌病不同心功能状态甲状腺激素水平变化及临床意义

- 西安交通大学第一附属医院心血管内科(西安, 710061)
基金项目:
西安市科技计划项目(No:SF1416-2)

详细信息

通讯作者: 袁祖贻,E-mail:zuyiyuan@mail.xjtu.edu.cn

中图分类号: R542.2

收稿日期: 2016-09-29

修回日期: 2017-01-12

Thyroid hormone levels and heart function in patients with dilated cardiomyopathy

- Department of Cardiology, the First Affiliate Hospital of Xi'an Jiaotong University, Xi'an, 710061, China

More Information

Corresponding author: YUAN Zuyi, E-mail: zuyiyuan@mail.xjtu.edu.cn

Received Date: 29 September 2016

Revised Date: 12 January 2017

摘要

摘要: 目的:研究扩张型心肌病(DCM)不同心功能状态时甲状腺激素水平的变化。方法:选取DCM患者106例,NYHAⅡ级32例(Ⅱ级组),NYHA Ⅲ级48例(Ⅲ级组), NYHAⅣ级26例(Ⅳ级组)。入院后完善生化检查和心脏超声。再根据患者血清游离三碘甲状腺原氨酸(FT3)水平四分位数进行分组,比较不同FT3组左室射血分数(LVEF)、高敏C反应蛋白(hsCRP)、氨基末端B型脑钠肽前体(NT-proBNP)的差别。结果:经单因素方差分析,NYHAⅡ级组、Ⅲ级组、Ⅳ级组之间NT-proBNP、hsCRP的差异有统计学意义(P＜0.01);FT3和总三碘甲状腺原氨酸 (TT3)之间差异亦有统计学意义(P＜0.01);而促甲状腺激素(TSH)、游离甲状腺素 (FT4)、总甲状腺素(TT4)无统计学意义(P＞0.05)。在以FT3四分位数进行分组中,FT3越低,LVEF就越低,而hsCRP和NT-proBNP越高。结论:DCM的FT3越低,则LVEF越低,同时hsCRP、NT-proBNP越高,预测患者的临床风险的增加。
- 扩张型心肌病 /
- 氨基末端B型脑钠肽前体 /
- 游离三碘甲状腺原氨酸 /
- 高敏C反应蛋白 /
- 左室射血分数
Abstract: Objective:To investigate the relationship between thyroid hormone levels and heart function in patients with dilated cardiomyopathy. Method:A total of 106 patients with dilated cardiomyopathy was enrolled in this study, including 32 patients in NYHA Ⅱ group, 48 patients in NYHAⅢ group, 26 patients in NYHA Ⅳ group. Laboratory and echocardiographic indicators were collected. Based on serum FT3 level, quartile subgroup were adopted. We analysis the left ventricular ejection fraction(LVEF), high sensitivity C-reactive protein (hsCRP), N-Terminal pro-brain natriuretic peptide precursor (NT-proBNP) in different FT3 subgroups. Result: Among the NYHAⅡ, Ⅲ and Ⅳ groups, NT-proBNP and hsCRP had significant differences(P＜0.01). FT3 and TT3 had significant differences(P＜0.01), while TSH, FT4, and TT4 didn't have any differences(P＞0.05) . In the lower FT3 group, we would found the lower LVEF is lower , and the higher hsCRP and NT-proBNP is higher. Conclusion:Low FT3 usually associates with low LVEF or high hsCRP and NT-proBNP, which predicts high clinical risks in patients with dilated cardiomyopathy.
- dilated cardiomyopathy /
- N-Terminal pro-brain natriuretic peptide precursor /
- free triiodothyronin /
- high sensitivity C-reactive protein /
- left ventricular ejection fraction

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