雌激素水平对绝经后女性急性心肌梗死发生的影响研究

董海秋; 董梅; 任法新

doi:10.13201/j.issn.1001-1439.2017.02.013

雌激素水平对绝经后女性急性心肌梗死发生的影响研究

- 青岛大学医学院附属医院烟台毓璜顶医院心血管内科(山东烟台, 264000)
基金项目:
山东省自然科学基金联合专项(No:ZR2015HL004)

烟台市科技发展计划(No:2015WS031)

详细信息

通讯作者: 任法新,E-mail:drren@163.com

中图分类号: R542.2

收稿日期: 2016-08-18

修回日期: 2016-12-03

Impact of oestrogens on the risk of acute myocardial infarction among postmenopausal women

- Department of Cardiology, Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University, Qingdao, 264000, China

More Information

Corresponding author: REN Faxin, E-mail: drren@163.com

Received Date: 18 August 2016

Revised Date: 03 December 2016

摘要

摘要: 目的:本研究探讨内源性雌激素水平对绝经后女性急性心肌梗死(AMI)发生的影响。方法:本研究共计纳入30例绝经后女性AMI患者(AMI组)和60例健康绝经后女性(对照组)。所有患者均检测内源性性激素水平(包括血雌酮、雌二醇、雄烯二醇和睾酮水平)。多因素Logistic 回归分析性激素水平与AMI发生风险的关系。结果:与对照组相比,AMI组的血雌酮、雌二醇、雄烯二醇和睾酮水平明显升高 (P＜0.05),而性激素结合球蛋白(SHBG)水平却减低 (P＜0.05)。单因素Logistic回归分析显示,雌酮、雌二醇、睾酮、臀腰比、体质指数、糖尿病和高血压均与AMI发生呈正相关 (P＜0.05)。校正这些因素后,雌二醇[比值比(OR) 4.75,95% 可信区间(CI) :1.07~21.10,P＜0.05]和腰臀比(OR=6.46,95%CI:1.09~38.39,P＜0.05)仍和AMI呈正相关。结论:高雌二醇水平与绝经后女性AMI的发生呈正相关,提示内源性高雌激素可能是绝经后女性AMI发生的独立危险因素。
- 雌激素 /
- 急性心肌梗死 /
- 急性应激 /
- 脂肪组织 /
- 绝经后女性
Abstract: Objective:To investigate the correlation between endogenous oestrogens and acute myocardial infarction (AMI) risk among postmenopausal women.Method:A case-control study was performed among 30 AMI patients among postmenopausal women and 60 control subjects. The serum levels of endogenous sex hormones levels were detected.Conditional Logistic regression models were developed with adjustment for confounders.Result:Compared with controls, the circulating oestrone, oestradiol, androstenedione and testosterone levels were significantly higher in AMI patients (P＜0.05) while the sex hormone binding globulin (SHBG) level was lower (P＜0.05). In univariable Logistic regression models, oestrone, oestradiol, testosterone, WHR, BMI, diabetes and hypertension were all found to be positively associated with AMI (P＜0.05). After adjusting for these factors, oestradiol [odds ratio (OR)=4.75,95%confidence interval (CI):1.07~21.10,P＜0.05] and WHR (OR=6.46,95% CI:1.09~38.39,P＜0.05) continued to demonstrate strong positive associations with AMI. Conclusion:A higher level of oestradiol is potentially associated with AMI risk among postmenopausal women.
- oestrogens /
- acute myocardial infarction /
- acute stress /
- adipose tissue /
- postmenopausal women

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