Th22细胞及其细胞因子IL-22与冠心病发病机制的研究进展

杨新超; 姜曼; 胡钢

doi:10.13201/j.issn.1001-1439.2017.09.005

Th22细胞及其细胞因子IL-22与冠心病发病机制的研究进展

- 长江大学第二临床医学院(湖北荆州, 434023)

详细信息

通讯作者: 胡钢, E-mail:hugang@medmail.com.cn

中图分类号: R541.4

收稿日期: 2016-11-14

修回日期: 2017-03-13

Advances in the research on the role of Th22 cells and its cytokine IL-22 on the pathogenesis of coronary heart disease

- The Secord Clinical Medical College of Yangtze University, Jinzhou, 434023, China

More Information

Corresponding author: HU Gang, E-mail: hugang@medmail.com.cn

Received Date: 14 November 2016

Revised Date: 13 March 2017

摘要

摘要: Th22是近几年新发现的一种辅助型T细胞亚群。Th22细胞及其主要的细胞因子白细胞介素22(IL-22)被证实在各种自身免疫疾病及慢性炎性疾病如类风湿性关节炎、银屑病、慢性异位性皮炎、哮喘、系统性硬化症等患者中均表达异常。然而关于Th22细胞及IL-22在冠心病中的作用及发病机制尚未明确。如能明确Th22及IL-22作用于冠心病的作用机制,可作为防治冠心病的新思路和新靶点。本文就Th22及其主要细胞因子IL-22的最新研究进展及临床应用现状做一全面综述。
- Th22 /
- 白细胞介素-22 /
- 冠心病
Abstract: Th22 is a newly T helper cell subsets, discovered in recent years.The abnormal expressions of Th22 cells and IL-22 are confirmed in a variety of autoimmune diseases and chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, atopic dermatitis, chronic asthma, systemic sclerosis.However, the current role and pathogenesis of Th22 cells and IL-22 in coronary heart disease is not yet clear.The mechanism of Th22 and IL-22 in coronary heart disease could be used as a new idea and new target for the prevention and treatment of coronary heart disease.To this end, the latest research progress and clinical application of Th22 and its main cytokine IL-22 are summarized as follows.
- Th22 /
- IL-22 /
- coronary heart disease

HTML全文

参考文献(27)

[1]	陶红梅, 覃数, 张冬颖.女性冠心病的研究进展[J].心血管病学进展, 2014, 35 (2):250-252.
[2]	HANSSON G K, HERMANSSON A.The immune system in atherosclerosis[J].Nat Immunol, 2011, 12:204-212.
[3]	MARTINS T B, ANDERSON J L, MUHLESTEIN JB, et al.Risk factor analysis of plasma cytokines in patients with coronary artery disease by a multiplexed fluorescent immunoassay[J].Am J Clin Pathol, 2006, 125:906-913.
[4]	ZHANG L, LI Y G, LI Y H, et al.Increased frequencies of Th22 cells as well as Th17 cells in the peripheral blood of patients with ankylosing spondylitis and rheumatoid arthritis[J].PLos One, 2012, 7:e3100.
[5]	XIA Q, XIANG X G, PATEL S, et al.Characterisation of IL-22and interferon-gamma-inducible chemokines in human carotid plaque[J].Int J Cardiol, 2012, 154:187-189.
[6]	SARA T, CHARLES D K, ELISE H T, et al.Identification of a human helper T cell population that has abundant production of interleukin 22and is distinct from Th17, Th1 and Th2 cells[J].Nat Immumol, 2009, 10:864-871.
[7]	DUHEN T, GEIGER R, JARROSSAY D, et al.Production of interleukin-22but not interleukin 17by a subset of human skin-homing memory T cells[J].Nat Immunol, 2009, 10:857-863.
[8]	RAMIREZ J M.BREMBILLA N C, SORG O, et al.Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL-22and IL-17production by human T helper cells[J].Eur J Immunol, 2010, 40:2450-2459.
[9]	EYERICH S, EYERICH K, PENNINO D, et al.Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling[J].JClin Invest, 2009, 119:3573-3585.
[10]	HEYDENREICH B, BELLINGHAUSEN I, KÖNIGB, et al.Gram-positive bacteria on grass pollen exhibit adjuvant activity inducing inflammatory T cell responses[J].Clin Exp Allergy, 2012, 42:76-84.
[11]	DUMOUTIER L, LOUAHED J, RENAULD J C.Cloning and characterization of IL-10-related T cellderived inducible factor (IL-TIF), a novel cytokine structurally related to IL-20and inducible by IL-9[J].J Immunol, 2000, 164:1814-1819.
[12]	ZHENG Y, WENJUN O, VALDEZ P, et al.Interleukin-22, a Th17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis[J].Nature, 2007, 445:648-651.
[13]	XIE M H, AGGARWAL S, HO W H, et al.Interleukin (IL) -22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4and IL-22R[J].J Biol Chem, 2000, 275:31335-31339.
[14]	刘昀, 吴长有.Th22细胞的研究进展[J].中国免疫学杂志, 2010, 26 (4);372-372.
[15]	JONES B C, LOGSDON N J, WATER M R.Structure of IL-22bound to its high-affinity IL-22R1 chain[J].Structure, 2008, 16:1333-1344.
[16]	WOLK K, WITTE E, WITTE K, et al.Biology of interleukin-22[J].Seminars in immunopathology, 2010, 32:17-31.
[17]	AUJLA S J, KOLLS J K.IL-22:a critical mediator in muscosal host defense[J].J Mol Med, 2009, 87:451-454.
[18]	SONNENBERG G F, NAIR M G, KIRM T J, et al.Pathological versus protective functions of IL-22in airway inflammation are regulated by IL-17A[J].JExp Med, 2010, 207:1293-1305.
[19]	LO Y H, KAN T, SAITO C, et al.Serum IL-22correlates with psoriatic severity and serum IL-6correlates with susceptibility to phototherapy[J].J Dermatol SCI, 2010, 58:225-227.
[20]	付才华, 杜乃立, 张磊, 等.外周血Th22和Th17细胞在急性心肌梗死患者中变化及临床意义[J].临床心血管病杂志, 2014, 30 (3):236-240.
[21]	BRANEN L, HOVGAARD L, NITULESCU M, et al.Inhibition of tumor necrosis factor-alpha reduces atherosclerosis in apolipoprotein E knockout mice[J].Arterioscler Thromb Vasc Biol, 2004, 24:2137-2142.
[22]	WOLK K, WITTE E, WALLACE E, et al.IL-22regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes:apotential role in psoriasis[J].Eur J Immunol, 2006, 36:1309-1323.
[23]	孙懿, 胡志德, 黄元兰, 等.IL-22抑制ox-LDL诱导的CRL-1730细胞凋亡并上调其Bcl-2表达[J].第二军医大学学报, 2011, 32 (3):233-237.
[24]	梁燕盆, 马捷.阻断JAK/STAT通道对大鼠缺血再灌注心肌细胞凋亡及Bcl-2/Bax表达的影响[J].中国药物与临床, 2010, 10 (4):424-426.
[25]	BONIFACE K, BERNARD F, GARCIA M, et al.IL-22inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes[J].J Immunol, 2005, 174:3695-3702.
[26]	ALTWEGG L A, NEIDHART M, HERSBERGER M, et al.Myeloid-related protein 8/14complex is released by monocytes and granulocytes at the site of coronary occlusion:a novel, early, and sensitive marker of acute coronary syndromes[J].Eur Heart J, 2007, 28:941-948.
[27]	CHANG H, HANAWA H, LIU H, et al.Hydrodynamic-based delivery of an interleukin-22-lg fusion gene ameliorates experimental autoimmune myocarditis in rats[J].J Immunol, 2006, 177:3635-3643.