肿瘤标志物CA125与特发性炎症性肌病合并心包积液的研究

彭方琴; 汪汉; 蔡琳; 叶滔; 刘涛

doi:10.13201/j.issn.1001-1439.2017.11.012

肿瘤标志物CA125与特发性炎症性肌病合并心包积液的研究

- 1 西南医科大学(四川泸州, 646100);
- 2成都市心血管病研究所(成都, 610031);
- 3 海南省人民医院神经内科(海口, 570311)
基金项目:
国家自然科学基金项目 (No:81300243)

四川省医学科研青年创新课题 (No:Q14013)

四川省卫计委普及应用项目 (No:16PJ042)

详细信息

通讯作者: 蔡琳, E-mail:cailinwm@163.com

中图分类号: R542.2

收稿日期: 2017-07-23

Tumor marker CA125 is associated with pericardial effusion in patients with idiopathic inflammatory myopathies

- 1 Southwest Medical University, Luzhou, 646100, China;
- 2 Cardiovascular Disease Research Institute, The Third People's Hospital of Chengdu, Chengdu, 610031, China;
- 3 Hainan Provincial People's Hospital

More Information

Corresponding author: CAI Lin, E-mail: cailinwm@163.com

Received Date: 23 July 2017

摘要

摘要: 目的:探讨肿瘤标志物CA125与特发性炎症性肌病合并心包积液的关系。方法:回顾性分析217例特发性炎症性肌病患者, 依据CA125水平分为CA125异常组及正常组, 并运用心脏彩超测量心包积液, 观察两组研究对象的一般信息、临床表现及心包积液情况, 运用logistic回归分析CA125水平与心包积液的相关性。结果:217例特发性炎症性肌病患者中, CA125异常者59例 (27.2%), 心包积液者9例 (15.3%);与正常组相比, CA125异常组心包积液差别存在统计学意义 (P=0.017), 且其总蛋白、白蛋白水平较低, 尿素、肌酐水平升高, 差异具有统计学意义 (P<0.05);logistics回归分析提示CA125水平与心包积液呈正相关 (OR=1.136, P=0.041;95%CI (1.048~9.246))。结论:特发性炎症性肌病合并心包积液并不少见, 且与CA125密切相关。
- 肿瘤标志物CA125 /
- 特发性炎症性肌病 /
- 心包积液
Abstract: Objective:To investigate the relationship between tumor marker CA125 and pericardial effusion in patients with idiopathic inflammatory myopathies.Method:Two hundred and seventeen patients with idiopathic inflammatory myopathies were included in this study.Routine information, clinical features, laboratory parameters, and pericardial effusion of these patients were analyzed.According to the level of CA125, all patients were divided into two groups, CA125 normal group and abnormal group.Echocardiography was used to evaluate pericardial effusion.Binary logistic regression was used to assess the relationship between CA125 and pericardial effusion.Result:Fifty-nine patients (27.2%) of the 217 idiopathic inflammatory myopathies patients had abnormal CA125, which had nine patients (15.3%) with pericardial effusion.Compared with the normal group, the difference of pericardial effusion in the abnormal group had statistical significance (P=0.017).In the abnormal group, the total protein and albumin levels were relatively lower, and the urea and creatinine levels were relatively higher (P<0.05).Logistic regression model demonstrated that the level of CA125 were associated with pericardial effusion in idiopathic inflammatory myopathies (OR=1.136, P=0.041, 95%CI 1.048~9.246).Conclusion:Pericardial effusion may be common in idiopathic inflammatory myopathies, and closely related to CA125.
- tumor marker CA125 /
- idiopathic inflammatory myopathies (IIM) /
- pericardial effusion

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