1.5T磁共振定量正常人左室心肌组织特性和心肌应变的初步研究

曹玉坤; 崔越; 曾文娟; 孔祥闯; 张珊; 宋晶; 史河水

doi:10.13201/j.issn.1001-1439.2017.11.014

1.5T磁共振定量正常人左室心肌组织特性和心肌应变的初步研究

- 1 华中科技大学同济医学院附属协和医院放射科(武汉, 430022);
- 2 华中科技大学同济医学院附属协和医院检验科
基金项目:
华中科技大学同济医学院附属协和医院科学研究基金项目 (No:02032017-113)

详细信息

通讯作者: 史河水, E-mail:heshuishi@hotmail.com

中图分类号: R445.2

收稿日期: 2017-05-17

Quantification of myocardial tissue characterization and strain of the left ventricle in healthy volunteers with 1.5T magnetic resonance:apreliminary study

- 1 Department of Radiology,;
- 2 Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

More Information

Corresponding author: SHI Heshui, E-mail: heshuishi@hotmail.com

Received Date: 17 May 2017

摘要

摘要: 目的:探究1.5T磁共振定量正常人左室心肌T1值、心肌细胞外容积 (ECV) 和心肌收缩峰值应力的正常值及其性别和节段差异。方法:共纳入46名健康志愿者行1.5T MR心脏增强检查, 通过运动自动校正反转恢复 (MOLLI) 序列分别获取基底段、中间段和心尖段T1mapping, 输入红细胞比容软件自动计算相应层面ECV mapping。分别勾画16段心肌感兴趣区并记录增强前、后T1值和ECV;将心脏电影导入后处理软件行组织追踪应力分析, 半自动计算整体和节段左室收缩峰值径向应力 (Err)、周向应力 (Ecc) 和纵向应力 (Ell)。结果:左室总体平均增强前T1值、增强后T1值和ECV值分别为 (1 009.4±24.8) ms、(468.4±30.9) ms、(24.8±2.5)%。其中, 女性增强前T1值和ECV值均高于男性[T1值:(1 020.2±20.8) ms︰ (999.5±24.3) ms;ECV值:(26.5±1.9)%︰ (23.1±1.8)%;均P<0.01];心尖段ECV值 (26.2±3.1)%均高于基底段 (24.2±2.4)%和中间段 (24.5±2.7)% (P<0.01);增强前T1值与年龄呈正相关 (r=0.371, P<0.01);增强前T1值和ECV与心肌质量呈负相关 (r值分别为-0.301、-0.585, 均P<0.05)。左室总体收缩峰值径向应力 (Err)、周向应力 (Ecc) 和纵向应力 (Ell) 分别为 (43.2±9.9)%、(-19.8±2.3)%、(-17.5±2.2)%。其中, 女性整体Ecc值和Ell值均高于男性[Ecc值:(-20.9±2.2)%︰ (-18.9±2.1)%;Ell值:(-18.6±2.1)%︰ (-16.5±1.7)%;均P<0.01];Err值在心尖段较高, 而Ecc和Ell值中间段较高 (P值均<0.01);Err值与年龄呈正相关 (r=0.304, P<0.05)。结论:正常人左室心肌增强前T1值、ECV、Err、Ecc和Ell值存在性别以及节段差异。增强前T1值与年龄呈正相关, 与心肌质量呈负相关, Err值与年龄呈正相关。
- 磁共振成像 /
- T1mapping /
- 细胞外容积 /
- 组织追踪 /
- 心肌应力
Abstract: Objective:To investigate the normal value and gender and segmental differences of T1 value, extracellular volume and systolic peak strain of the left ventricular myocardium in normal subjects with 1.5 T magnetic resonance.Method:We recruited 46 healthy subjects without any history of cardiovascular disease to undergo contrast-enhanced cardiac magnetic resonance imaging on a 1.5 T MR scanner.T1 mapping was acquired at basal, mid and apical segments before and 15 min after administration of gadolinium using a modified Look-Locker inversion recovery (MOLLI) sequence.Based on the hematocrit value of subjects, ECV mapping on the same level was automatically performed.The native and post T1 and ECV values were calculated in 16 regions of interest in left ventricle according to AHA 16 segments model.Myocardial stress analysis based on the tissue tracking technology was performed after cardiac cine data were imported into the post-processing software.And then we semi-automatically measured global and regional peak systolic radial, circumferential and longitudinal strain of the left ventricular myocardium.Result:The mean native and post T1 and ECV values of the left ventricular myocardium were (1 009.4±24.8) ms, (468.4±30.9) ms and (24.8±2.5)%.The T1 and ECV values in females were higher than males[T1:(1 020.2±20.8) ms vs. (999.5±24.3) ms, P<0.01;ECV:(26.5±1.9)% vs. (23.1±1.8)%, P<0.01].The apical segment had a significantly higher ECV than either middle or basal one[(26.2±3.1)%, (24.2±2.4)% and (24.5±2.7)%;P<0.01].The native T1 value was associated with age (r=0.371, P<0.01) and left ventricular mass (r=-0.301, P<0.05).And the ECV was related to left ventricular mass (r=-0.585, P<0.01).In addition, the peak systolic radial, circumferential and longitudinal strain of the left ventricular myocardium were (43.2±9.9)%, (-19.8±2.3)% and (-17.5±2.2)%.The global Ecc and Ell values in females were greater than males[Ecc:(-20.9±2.2)% vs. (-18.9±2.1)%, P<0.01;Ell:(-18.6±2.1)% vs. (-16.5±1.7)%, P<0.01].The Err values in apical segment and Ecc and Ell values in middle segment were higher than other segments (P<0.01).And the Err value correlated with age (r=0.304, P<0.05).Conclusion:Segment and gender variation of the left ventricle in native T1, ECV, Err, Ecc and Ell value are observed.The native T1 is associated with age and myocardial mass.And the Err value is correlated with age.
- magnetic resonance imaging /
- T1mapping /
- extracellular volume /
- tissue tracking /
- myocardial strain

HTML全文

参考文献(20)

[1]	HAAF P, GARG P, MESSROGHLI D R, et al.Cardiac T1 Mapping and Extracellular Volume (ECV) in clinical practice:a comprehensive review[J].J Cardiovasc Magnc Reson, 2016, 18:89.
[2]	SCHELBERT E B, MESSROGHLI D R.State of the Art:Clinical Applications of Cardiac T1 Mapping[J].Radiology, 2016, 278:658-676.
[3]	SCHUSTER A, HOR K N, KOWALLICK J T, et al.Cardiovascular magnetic resonance myocardial feature tracking:concepts and clinical applications[J].Circ Cardiovasc Imaging, 2016, 9:e4077.
[4]	CLAUS P, OMAR A M S, PEDRIZZETTI G, et al.Tissue tracking technology for assessing cardiac mechanics principles, normal values, and clinical applications[J].JACC Cardiovasc Imaging, 2015, 8:1444-1460.
[5]	CARBERRY J, CARRICK D, HAIG C, et al.Segmental variation in myocardial extracellular vlume in healthy mid-life adults[J].Heart, 2015, 101 (Suppl2):A4-A4.
[6]	LIU C, LIU Y, WU C, et al.Evaluation of age-related interstitial myocardial fibrosis with cardiac magnetic resonance contrast-enhanced T1 mapping[J].J Am Coll Cardiol, 2013, 62:1280-1287.
[7]	RAUHALAMMI S M, MANGION K, BARRIENTOS P H, et al.Native myocardial longitudinal (T1) relaxation time:Regional, age, and sex associations in the healthy adult heart[J].J Magn Reson Imaging, 2016, 44:541-548.
[8]	DABIR D, CHILD N, KALRA A, et al.Reference values for healthy human myocardium using a T1 mapping methodology:results from the International T1 Multicenter cardiovascular magnetic resonance study[J].J Cardiovasc Magn Reson, 2014, 16:69.
[9]	李松南, 赵蕾, 董建增, 等.3.0 TMR测量正常人左心室心肌纵向弛豫时间和细胞外容积比率[J].中华放射学杂志, 2016, 50 (12):929-934.
[10]	VON KNOBELSDORFF-BRENKENHOFF F, PROTHMANN M, DIERINGER M A, et al.Myocardial T1 and T2 mapping at 3T:reference values, influencing factors and implications[J].J Cardiovasc Magn Reson, 2013, 15:53.
[11]	SADO D M, FLETT A S, BANYPERSAD S M, et al.Cardiovascular magnetic resonance measurement of myocardial extracellular volume in health and disease[J].Heart, 2012, 98:1436-1441.
[12]	PIECHNIK S K, FERREIRA V M, LEWANDOWSKI A J, et al.Normal variation of magnetic resonance T1 relaxation times in the human population at 1.5T using ShMOLLI[J].J Cardiovasc Magn Reson, 2013, 15:13.
[13]	LIU H, YANG D, WAN K, et al.Distribution pattern of left-ventricular myocardial strain analyzed by a cine MRI based deformation registration algorithm in healthy Chinese volunteers[J].Scientific Reports, 2017, 7:45314.
[14]	BOGAERT J, RADEMAKERS F E.Regional nonuniformity of normal adult human left ventricle[J].Am J Physiol Heart Circ Physiol, 2001, 280:H610-620.
[15]	ANDRE F, STEEN H, MATHEIS P, et al.Ageand gender-related normal left ventricular deformation assessed by cardiovascular magnetic resonance feature tracking[J].J Cardiovasc Magn Reson, 2015, 17:25.
[16]	AUGUSTINE D, LEWANDOWSKI A J, LAZDAM M, et al.Global and regional left ventricular myocardial deformation measures by magnetic resonance feature tracking in healthy volunteers:comparison with tagging and relevance of gender[J].J Cardiovasc Magn Reson, 2013, 15:8.
[17]	TAYLOR R J, MOODY W E, UMAR F, et al.Myocardial strain measurement with feature-tracking cardiovascular magnetic resonance:normal values[J].Eur Heart J Cardiovasc Imaging, 2015, 16:871-881.
[18]	LE T T, RU S T, DEYN M D, et al.Cardiovascular magnetic resonance reference ranges for the heart and aorta in Chinese at 3T[J].J Cardiovasc Magn Reson, 2016, 18:21.
[19]	CHENG S, FERNANDES V R, BLUEMKE D A, et al.Age-related left ventricular remodeling and associated risk for cardiovascular outcomes:the Multi-Ethnic Study of Atherosclerosis[J].Circ Cardiovas Imaging, 2009, 2:191-198.
[20]	KELLMAN P, HANSEN M S.T1-mapping in the heart:accuracy and precision[J].J Cardiovasc Magn Reson, 2014, 16:2.