室性心律失常与解剖因素关系的研究进展

李奇; 杨俊

doi:10.13201/j.issn.1001-1439.2018.05.004

室性心律失常与解剖因素关系的研究进展

李奇,
杨俊^,

- 三峡大学心血管病研究所三峡大学第一临床医学院心内科(湖北宜昌, 443003)
基金项目:
国家自然科学基金 (No:81170133, 81670333)

湖北省科技支撑计划 (No:2015BKA340)

详细信息

通讯作者: 杨俊,E-mail:yangjun@ctgu.edu.cn

中图分类号: R541.7

收稿日期: 2017-11-29

Progress in the relationship between ventricular arrhythmias and anatomical factors

LI Qi,
YANG Jun^,

- Department of Cardiology, the First Affiliated Hospital of Three Gorges University, Yichang, 443003, China

More Information

Corresponding author: YANG Jun, E-mail: yangjun@ctgu.edu.cn

Received Date: 29 November 2017

摘要

摘要: 室性心律失常 (VAs) 是指起源于心室异位节律点的心律紊乱, 易导致心源性猝死的发生。与VAs的发生相关的解剖因素复杂多样, 包括浦肯野纤维、Marshall韧带、心脏自主神经等, 这些解剖因素的结构特征及电生理特点在VAs的触发和维持中发挥着重要作用。本文对VAs的解剖因素进行归纳总结, 并简要介绍其导致VAs的作用机制。
- 室性心律失常 /
- 浦肯野纤维 /
- Marshall韧带 /
- 心脏自主神经
Abstract: Ventricular arrhythmias (VAs) are cardiac arrhythmias originating from the ectopic rhythm of the ventricles, which can lead to sudden cardiac death.The anatomic structures relevant to the pathogenesis of AF are complex and varied, including Purkinje fibers, Ligament of Marshall, and Cardiac autonomic nervous system.The structural features and electrophysiological features of the above anatomical factors play an important role in the initiation and maintenance of VAs.Therefore, this present review primarily focuses on the multiple anatomical factors of VAs and make a brief introduction of that factors lead to VAs.
- ventricular arrhythmias /
- purkinje fibers /
- ligament of Marshall /
- cardiac autonomic nervous system

HTML全文

参考文献(29)

[1]	Kokolis S,Clark LT,Kokolis R,et al.Ventricular Arrhythmias and Sudden Cardiac Death[J].Lancet,2012,380(9852):1520-1529.
[2]	Campos FO,Shiferaw Y,Vigmond EJ,et al.Stochastic spontaneous calcium release events and sodium channelopathies promote ventricular arrhythmias[J].Chaos,2017,27(9):093910.
[3]	Haissaguerre M,Vigmond E,Stuyvers B,et al.Ventricular arrhythmias and the His-Purkinje system[J].Nature Reviews Cardiology,2016,13(3).
[4]	李毅刚,李威.蒲肯野纤维与室性心律失常[J].临床心血管病杂志,2017,33(3):197-199.
[5]	Ideker RE,Kong W,Pogwizd S.Purkinje fibers and arrhythmias[J].Pacing & Clinical Electrophysiology Pace,2009,32(3):283.
[6]	Dobrzynski H,Anderson RH,Atkinson A,et al.Structure,function and clinical relevance of the cardiac conduction system,including the atrioventricular ring and outflow tract tissues[J].Pharmacology & Therapeutics,2013,139(2):260.
[7]	Pavlovic N,Reichlin T,Knecht S,et al.Isolation of an automatic purkinje focus for ablation of an incessant ventricular tachycardia[J].Circulation Arrhythmia & Electrophysiology,2014,7(6):1275-1276.
[8]	Enjoji Y,Mizobuchi M,Muranishi H,et al.Catheter ablation of fatal ventricular tachyarrhythmias storm in acute coronary syndrome——role of Purkinje fiber network[J].J Interv Card Electrophysiol,2009,26(3):207-215.
[9]	Haïssaguerre M,Shah DC,Jaïs P,et al.Role of Purkinje conducting system in triggering of idiopathic ventricular fibrillation[J].Lancet,2002,359(9307):677-8.
[10]	Song Z,Ko CY,Nivala M,et al.Calcium-Voltage Coupling in the Genesis of Early and Delayed Afterdepolarizations in Cardiac Myocytes[J].Biophysical Journal,2015,108(8):1908-21.
[11]	Boyden PA,Wen D,Robinson RB.Cardiac Purkinje fibers and Arrhythmias;The GK Moe award Lecture 2015[J].Heart Rhythm,2016,13(5):1172-1181.
[12]	Deo M,Boyle PMKim AM,Vigmond EJ.Arrhythmogenesis by single ectopic beats originating in the Purkinje system[J].American Journal of Physiology Heart & Circulatory Physiology,2010,299(4):H1002.
[13]	Li W,Yu Y,Hou JW,et al.Larger rate dependence of late sodium current in cardiac Purkinje cells:A potential link to arrhythmogenesis[J].Heart Rhythm,2017,14(3):422.
[14]	Koizumi A,Sasano T,Kimura W,et al.Genetic defects in a His-Purkinje system transcription factor,IRX3,cause lethal cardiac arrhythmias[J].European Heart Journal,2016,37(18):1469.
[15]	谢强,黄从新,李卫华,等.Marshall韧带的形态学研究[J].中国心脏起搏与心电生理杂志,2006,20(3):217-221.
[16]	Macedo PG,Kapa S,Mears JA,et al.Correlative anatomy for the electrophysiologist:ablation for atrial fibrillation.Part Ⅰ:pulmonary vein ostia,superior vena cava,vein of Marshall[J].Journal of Cardiovascular Electrophysiology,2010,21(6):721.
[17]	谢强,黄从新,黄见亭,等.犬Marshall韧带心肌细胞电生理特性的研究[J].中华心血管病杂志,2005,33(3):251-254.
[18]	Lin J,Scherlag BJ,Lu Z,et al.Inducibility of Atrial and Ventricular Arrhythmias Along the Ligament of Marshall:Role of Autonomic Factors[J].Journal of Cardiovascular Electrophysiology,2008,19(9):955-962.
[19]	Wang S,Lu Z,He W,et al.Selective ablation of the ligament of Marshall reduces the prevalence of ventricular arrhythmias through autonomic modulation in a cesium-induced long QT canine model[J].Jacc Clinical Electrophysiology,2016,2(1):97-106.
[20]	Armour JA.Functional anatomy of intrathoracic neurons innervating the atria and ventricles[J].Heart Rhythm the Official Journal of the Heart Rhythm Society,2010,7(7):994-6.
[21]	Shen MJ,Zipes DP.Role of the autonomic nervous system in modulating cardiac arrhythmias[J].Circulation Research,2014,114(6):1004.
[22]	Kimura K,Ieda M,Fukuda K.Development,maturation,and transdifferentiation of cardiac sympathetic nerves[J].Circulation Research,2012,110(2):325-36.
[23]	Franciosi S,Perry FK,Roston TM,et al.The role of the autonomic nervous system in arrhythmias and sudden cardiac death[J].Autonomic Neuroscience Basic & Clinical,2017,205:1-11.
[24]	Cho Y.Left cardiac sympathetic denervation:An important treatment option for patients with hereditary ventricular arrhythmias[J].Journal of Arrhythmia,2016,32(5):340-343.
[25]	Ukena C,Bauer A,Mahfoud F,et al.Renal sympathetic denervation for treatment of electrical storm:first-in-man experience[J].Clinical Research in Cardiology Official Journal of the German Cardiac Society,2012,101(1):63-67.
[26]	Yu L,Huang B,Wang Z,et al.Impacts of Renal Sympathetic Activation on Atrial Fibrillation:The Potential Role of the Autonomic Cross Talk Between Kidney and Heart[J].Journal of the American Heart Association Cardiovascular & Cerebrovascular Disease,2017,6(3):C86-C87.
[27]	Ardell JL,Andresen MC,Armour JA,et al.Translational neurocardiology:preclinical models and cardioneural integrative aspects[J].J Physiol,2016,594(14).
[28]	Wang S,Zhou X,Huang B,et al.Spinal cord stimulation protects against ventricular arrhythmias by suppressing left stellate ganglion neural activity in an acute myocardial infarction canine model[J].Heart Rhythm,2015,12(7):1628-1635.
[29]	Howardquijano K,Takamiya T,Dale EA,et al.Spinal cord stimulation reduces ventricular arrhythmias during acute ischemia by attenuation of regional myocardial excitability[J].American Journal of Physiology Heart & Circulatory Physiology,2017,313(2):ajpheart.00129.2017.