Association of genetic polymorphism of MTHFR C677T and Coronary Heart Disease in the Chinese population:a meta-analysis
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摘要: 目的:探讨亚甲基四氢叶酸还原酶 (MTHFR) 基因C677T多态性和中国人群冠心病之间的关系。方法:从数据库PubMed、Medline、CNKI及WanFang Data网站上检索并收集中国相关人群的MTHFR基因C677T多态性与冠心病风险的病例-对照研究, 检索时限截至2017年10月。按照纳入与排除标准筛选文献、提取资料并评价纳入研究的质量后, 用Stata 12.0软件进行Meta分析、发表偏倚评估和敏感性分析。为更好地阐明研究中的异质性, 在研究中使用亚组分析。结果:共获得64篇相关文献, 15篇纳入研究。MTHFR基因C677T多态性与冠心病病例-对照研究中, 共有冠心病患者2 073例, 对照组2 072例。MTHFR基因C677T多态性与冠心病相关性经Meta分析结果显示, 在5个遗传模型中所有的遗传模型都提示MTHFR基因C677T多态性与冠心病发病风险的相关性具有统计学意义。在隐性遗传模型和杂合子模型中, MTHFR C677T基因多态性与冠心病的联系在中国北方地区具有显著性 (P＜0.001;P=0.003), 但在中国南方地区, MTHFR C677T基因多态性与冠心病之间没有显著联系 (P=0.082;P=0.060)。在其他3种模型中, MTHFRC677T基因多态性与冠心病的关系在中国的北部和南部地区具有重要意义。结论:MTHFR基因C677T多态性与中国人群冠心病易感性密切相关, TT可能是冠心病易感的危险因素。Abstract: Objective: To evaluate the associations between the methylenetetra hydrofolate reductase (MTHFR) gene C677 Tpolymorphism and risk of coronary artery Disease (CAD).Method: We collect related crowd (MTHFR) gene C677 Tpolymorphism and the risk of CAD in the case-control study through the following electronic databases:PubMed, Medline, CNKI and WanFang Data.Meta-analysis, publication bias and sensitivity analysis were performed by using Stata statistical software 12.0.In order to better clarify the heterogeneity among our studies, we used subgroup analysis in the region study.Result: A total of 64 relevant articles were selected and 15 of them met the criteria.Our meta-analysis results revealed that the MTHFR C677 Tpolymorphism might increase the risk of CAD in five models.In the recessive inheritance model and heterozygote model, the association between MTHFR C677 Tgene polymorphism and CHD was significant in the northern region of China (P＜ 0.001;P=0.003), but no significant association between MTHFR C677 Tgene polymorphism and CHD in the southern region of china (P=0.082;P=0.060).In other three models, the association between MTHFR C677 Tgene polymorphism and CHD was significant in the northern and southern region of China.Conclusion: MTHFR C677 Tpolymorphism may play a role in CAD susceptibility.TT is a risk factor for CAD.
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