老年冠心病患者合并肌肉减少症的相关性研究

王茜婷; 刘梅林

doi:10.13201/j.issn.1001-1439.2018.12.008

老年冠心病患者合并肌肉减少症的相关性研究

王茜婷,
刘梅林^,

- 北京大学第一医院老年病内科(北京, 100034)
基金项目:
北京大学第一医院科研种子基金 (No:2018SF057)

详细信息

通讯作者: 刘梅林,E-mail:liumeilin@hotmail.com

中图分类号: R541.4

收稿日期: 2018-08-20

Relationship between coronary heart disease and sarcopenia in the elderly

WANG Xiting,
LIU Meilin^,

- Department of Geriatric, Peking University First Hospital, Beijing, 100034, China

More Information

Corresponding author: LIU Meilin, E-mail: liumeilin@hotmail.com

Received Date: 20 August 2018

摘要

摘要: 目的:肌肉减少症是随增龄出现的骨骼肌肌肉质量进行性减少和 (或) 肌强度下降及肌肉生理功能减退的综合征, 是老年人动脉粥样硬化性心血管疾病的独立危险因素。对老年冠心病患者合并肌肉减少症的相关情况进行分析, 有助于优化老年冠心病患者的治疗。方法:选取2014-12-2018-04于北京大学第一医院老年病内科住院治疗的老年冠心病患者为研究对象, 收集入选对象的临床资料并建立数据库。将患者分组为肌少症及非肌少症组, 对比两组患者的一般临床资料、理化指标、身体成分及心脏结构及功能等指标, 并进行统计学分析。结果:① 老年冠心病患者同时患肌肉减少症者占26.69%, 其中男性、女性分别为25.10%、34.62%, 随着年龄增长患病率升高。② 肌少症组平均年龄及吸烟率更高, 肌酐清除率、血红蛋白浓度、高密度脂蛋白胆固醇 (HDL-C)、25-羟基维生素D、三酰甘油 (TG) 及血尿酸水平更低。③ 肌少症组的内脏脂肪面积、腹部皮下脂肪面积、体脂肪质量及BMI均低于非肌少症组; ④ 肌少症组左房前后径、左室舒张末内径明显增大, B型钠尿肽 (BNP) 水平更高, 最大运动功量及Berthel指数评分显著低于非肌少症组 (均P＜0.05)。结论:老年冠心病患者更易患肌少症, 合并肌少症的患者心脏结构、功能及运动耐量更差, 更需早期干预。
- 老年 /
- 冠心病 /
- 肌肉减少症
Abstract: Objective: Sarcopenia, an independent risk factor of ASCVD in the elderly, is a syndrome characterized by age-related decline of skeletal muscle plus low muscle strength and/or physical performance.It is necessary to study the relationship between coronary heart disease (CHD) and sarcopenia in the elderly to optimize the treatment.Method: The elderly patients with CHD who were hospitalized in the Peking University First Hospital from 2014.12 to 2018.4 were included in the study, and the clinical data were collected.The patients were divided into sarcopenia group and non-sarcopenia group.We analyzed respectively the difference on general clinical data, the physical and chemical index, body composition and the index of cardiac structure and function between the two groups.Result: ① Among the elderly patients with coronary heart disease, the number of patients with sarcopenia was 26.69% and increased with age, of which 25.10% were male and 34.62% were female. ② The patient's average age and smoking rates were higher and the level of creatinine clearance, hemoglobin concentration, HDL-C, 25-OH-VitD, TG and blood uric acid were lower in sarcopenia group (P＜0.05). ③ The visceral fat area, subcutaneous fat area, body fat mass and BMI were lower in sarcopenia group (P＜0.05). ④ The left atrial diameter, left ventricular diastolic diameter and the BNP level were significantly higher and the maximum exercise capacity and Berthel index score were significantly lower in sarcopenia group (P＜0.05).Conclusion: Elderly patients with CHD are more likely to suffer from sarcopenia.The cardiac structure, function and exercise tolerance are worse in sarcopenia patients, for whom early intervention is needed.
- elderly /
- coronary heart disease /
- sarcopenia

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