老年慢性心力衰竭患者血清可溶性尿激酶型纤溶酶原激活物受体水平变化及临床意义

鲁志科; 孙榕; 陈硕

doi:10.13201/j.issn.1001-1439.2019.03.016

老年慢性心力衰竭患者血清可溶性尿激酶型纤溶酶原激活物受体水平变化及临床意义

- 武汉科技大学附属孝感市中心医院心内科(湖北孝感, 432000)

详细信息

通讯作者: 鲁志科,E-mail:luzhike22@163.com

中图分类号: R541.6

收稿日期: 2018-09-19

修回日期: 2018-10-25

Clinical value of change of serum level of suPAR in elderly patients with chronic heart failure

- Department of Cardiology, Xiaogan Central Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan, Hubei, 432000, China

More Information

Corresponding author: LU Zhike, E-mail: luzhike22@163.com

Received Date: 19 September 2018

Revised Date: 25 October 2018

摘要

摘要: 目的：探讨可溶性尿激酶型纤溶酶原激活物受体（suPAR）水平对老年慢性心力衰竭（CHF）患者的早期诊断及预后评估的价值。方法：筛选2016-01-2017-08本院收治的105例CHF患者（CHF组），心功能Ⅱ级28例，心功能Ⅲ级55例，心功能Ⅳ级22例。另设同期健康体检且结果为正常者50例为对照组。使用双抗体夹心酶联免疫吸附（Elisa）法检测2组研究对象血清suPAR水平。应用超声心动图测定心功能，并计算平均室壁应力（MWS）和左心室心肌质量指数（LVMI）。比较2组研究对象及不同心功能分级患者的血清suPAR水平及心功能LVMI、MWS水平。CHF老年患者血清suPAR水平经Pearson分析与LVMI、MWS呈明显相关性。出院后第12个月心脏彩超复查患者心功能，统计发生心脏事件的病例数，比较并发心脏事件与无心脏事件发生的患者入院时血清suPAR水平。多因素logistic回归分析血清suPAR水平与CHF患者心脏事件的相关性。结果：与对照组比较，CHF组患者血清suPAR水平及MWS、LVMI增高，且随心功能分级增大而显著增加，差异有统计学意义（P<0.01）。CHF老年患者血清suPAR水平经Pearson分析与MWS和LVMI呈正相关（r=0.609和0.644，P=0.000和0.000）。出院后第12个月发现，随访并发心脏事件的CHF老年患者入院时血清suPAR水平显著高于无心脏事件患者。CHF老年患者血清suPAR水平经多因素Logistic回归分析确定为发生12个月心脏事件的危险因素之一。结论：血清suPAR水平可能是CHF老年患者早期诊断及其预后判断的有效指标之一。
- 慢性心力衰竭 /
- 老年 /
- 可溶性尿激酶型纤溶酶原激活物受体 /
- 预后
Abstract: Objective: To investigate the value of serum level of soluble urokinase-type plasminogen activator receptor(suPAR) in early diagnosis and prognosis of elderly patients with chronic heart failure(CHF). Method: One hundred and five elderly patients with CHF(CHF group) were selected in our hospital from Jan of 2016 to Aug of 2018 with cardiac function grade Ⅱ 28 cases, cardiac function grade Ⅲ 55 cases, and cardiac Ⅳ 22 cases. Menwhile fifty health elderly people were enrolled as control group subjects (control group).Double antibody sandwich enzyme-linked immunosorbent assay (Elisa) was used to measure serum level of suPAR for two groups. was employed to detect heart function and mean wall stress (MWSs) and left ventricular mass index (LVMI) were counted.Serum level of sTREM-1 and MWSs and LVMI were compared between both groups and among patients with different cardiac functional grades.The correlation between serum level of sTREM-1 and LVMI and MWS was analyzed by pearson linear correlation analysis in elderly patients.Cardiac function was reviewed by color doppler ultrasound at 12 months after discharge, the number of cases of cardiac events were counted, and serum level of suPAR was compared in cases with cardiac events and cases without cardiac events on admission.Relatioship between serum level of suPAR and cardiac events was analyzed by multivariate logistic regression analysis.Result: Serum level of suPAR in CHF patients was significantly higher than that in the control group and significantly with the increase of cardiac function grade. Serum level of suPAR of elderly CHF patients was positively correlated with the MWS and LVMI(r=0.609 and 0.644, P=0.000 and 0.000). Its level was obviously higher in cases with cardiac events than those without cardiac events at followed up for 12 months(P<0.01).Serum level of suPAR in elderly patients with CHF was one of hazards factors of 12 months cardiac events.Conclusion: Serum level of suPAR can be one of effective indexes for the early diagnosis and prognosis in elderly patients with CHF.
- chronic heart failure /
- elderly patients /
- soluble urokinase-type plasminogen activator receptor /
- prognosis

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