2015至2017年ACS患者疾病谱变化及危险因素分析

刘江萍; 张雷; 刘志强; 木胡牙提; 何鹏义; 杨玉春; 王姣

doi:10.13201/j.issn.1001-1439.2019.04.015

2015至2017年ACS患者疾病谱变化及危险因素分析

- 新疆医科大学第一附属医院综合心脏内科(乌鲁木齐, 830054)
基金项目:
国家自然科学基金（No：81760062）

详细信息

通讯作者: 木胡牙提,E-mail:muhuyati@163.com

中图分类号: R541.4

收稿日期: 2018-11-23

Analysis of disease spectrum changes and risk factors in patients with acute coronary syndrome in our hospital from 2015 to 2017

- Department of Cardiology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China

More Information

Corresponding author: Muhuyati, E-mail: muhuyati@163.com

Received Date: 23 November 2018

摘要

摘要: 目的：探讨2015-2017年我院住院急性冠状动脉综合征（ACS）患者疾病谱及其变化趋势，以及2017年ACS患者传统及非传统心血管危险因素的性别、年龄及亚型差异性。方法：收集2015-01-2017-12这3年间，急诊入住新疆医科大学第一附属医院心脏中心行直接PCI治疗且相关人口学、临床资料齐全的ACS患者758例，应用SPSS 22.0统计软件回顾性分析ACS的构成比及逐年变化；进一步分析2017年296例ACS患者传统及非传统危险因素在性别、年龄、亚型疾病之间的差异。结果：①近3年我院ACS患者中ST段抬高型心肌梗死（STEMI）构成比呈逐年下降趋势，不稳定型心绞痛（UAP）及非ST段抬高型心肌梗死（NSTEMI）构成比呈逐年上升趋势；男性构成比均呈逐年下降趋势，女性构成比均呈逐年上升趋势。②女性ACS患者合并高血压、2型糖尿病史均高于男性；而合并吸烟、血脂代谢异常史、血尿酸均低于男性，差异均有统计学意义（均P<0.05）。③NSTEMI组年龄、空腹血糖、N末端B型钠尿肽前体、肌酸激酶同工酶水平明显高于UAP组，左心室射血分数高于STEMI组，差异均有统计学意义（均P<0.05）；STEMI组低密度脂蛋白胆固醇、血浆纤维蛋白原、D-二聚体、N末端B型钠尿肽前体、超敏C反应蛋白、左室舒张末期内径高于UAP组（P<0.05）。结论：近3年我院ACS高龄女性住院患者数量、NSTEMI及UAP患者构成比逐年上升，应引以重视。ACS患者传统危险因素在性别、年龄上存在显著差异，而多项非传统危险因素指标在ACS亚型疾病上存在显著差异，非传统危险因素指标的监测及控制在临床诊治过程中不容忽视。
- 急性冠状动脉综合征 /
- 疾病谱 /
- 传统危险因素 /
- 非传统危险因素
Abstract: Objective: To investigate the disease spectrum and trends of patients with acute coronary syndrome (ACS) in our hospital from 2015 to 2017, and the gender, age and subtype differences of traditional and non-traditional cardiovascular risk factors in ACS patients in 2017.Method: The 758 patients with ACS who underwent emergency percutaneous coronary intervention (PCI) in our hospital were selected.SPSS 22.0 statistical soft ware was used to analyze the composition ratio of ACS and differences between 296 patients with ACS with traditional and non-traditional risk factors in gender, age and subtype.Result: ①The composition ratio of ST-segment elevation myocardial infarction in patients with ACS in our hospital showed a decreasing trend year by year.The composition ratio of unstable angina and non-ST-segment elevation myocardial infarction increased year by year.The male composition ratio is decreasing year by year, and the female composition ratio is increasing year by year.②The incidence of hypertension and type 2 diabetes in women with ACS was higher than in men.The smoking, abnormal lipid metabolism and blood uric acid were lower than in males (P<0.05).③The age, fasting blood glucose, N-terminal B-type natriuretic peptide precursor and creatine kinase isoenzyme levels in the NSTEMI group were significantly higher than UAP group.The left ventricular ejection fraction was higher than STEMI group (both P<0.05).STEMI group low-density lipoprotein cholesterol, plasma fibrinogen, D-dimer, N-terminal B-type natriuretic peptide precursor, high-sensitivity C-reactive protein, left ventricular end-diastolic inner diameter higher than UAP group (P<0.05).Conclusion: This study found that the number of older woman patients with ACS, the proportion of NSTEMI and UAP patients increased year by year should be taken seriously.The traditional risk factors of ACS patients are significantly different in gender and age, and many non-traditional risk factors have significant differences in ACS subtype diseases.The monitoring and control of non-traditional risk factors can not be ignored in clinical diagnosis and treatment.
- acute coronary syndrome /
- disease spectrum /
- traditional risk factors /
- non-traditional risk factors

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