The relationship between soluble ST2 concentration and diastolic heart failure in essential hypertension patients
-
摘要: 目的:探讨原发性高血压 (EH) 患者血浆sST2浓度与舒张性心力衰竭 (DHF) 的关系。方法:采用横断面调查研究, 选择2017-06-2017-12在新乡市中心医院就诊的EH患者76例为研究对象, 并分为EH组 (40例) 与DHF组 (EH合并DHF, 36例) 。记录左室质量指数、血浆sST2浓度和N末端脑钠肽前体 (NT-proBNP) 浓度。结果:DHF组患者左室质量指数、sST2浓度和NT-proBNP浓度均明显高于EH组 (均P<0.05) 。sST2预测EH患者发生DHF的ROC曲线下面积为0.81 (95%CI:0.68~0.87) , 高于NT-proBNP的曲线下面积0.74 (95%CI:0.59~0.83) 。Logistic回归分析显示, sST2浓度和NT-proBNP浓度是EH患者发生DHF的独立预测因素。结论:sST2浓度和NT-proBNP浓度对EH患者发生DHF具有良好的辅助诊断价值。Abstract: Objective:To investigate the relationship between soluble ST2 concentration and diastolic heart failure (DHF) in essential hypertension (EH) patients.Method:This was a hospital-based single-center cross-sectional study.A total of 76 cases with EH in Xinxiang Central Hospital from June 2017 to December 2017 were randomly divided into EH group (n=40) and DHF group (with EH andDHF, n=36) .Left ventricular mass index, NT-proBNP and soluble ST2 concentrations were recorded.Result:Left ventricular mass index, NT-proBNP and soluble ST2 concentration were higher in DHF group than those in EH group (all P<0.05) .The area under the receiver operating characteristic curve (AUC) of soluble ST2 predicting DHF in EH patients was 0.81 (95%CI:0.68-0.87) , which was higher than that of NT-proBNP (AUC:0.74, 95%CI:0.59-0.83) .Logistic regression analysis showed that NT-proBNP and soluble ST2 concentration were independent predictors of DHF in EH patients.Conclusion:Plasma soluble ST2 and NT-proBNP concentrations are good predictorsfor DHF in EH patients.
-
Key words:
- hypertension /
- soluble ST2 /
- diastolic heart failure /
- left ventricular mass index /
-
-
[1] Okin PM, Devereux RB, Jern S, et al.Regression of electrocardiographic left ventricular hypertrophy during antihypertensive treatment and the prediction of major cardiovascular events[J].JAMA, 2004, 292 (19):2343-2349.
[2] Pascual-Figal DA, Januzzi JL.The biology of ST2:the international ST2consensus panel[J].Am J Cardiol, 2015, 115 (7suppl):3B-7B.
[3] 中华医学会心血管病学分会心力衰竭学组, 中国医师协会心力衰竭专业委员会, 中华心血管病杂志编辑委员会.中国心力衰竭诊断和治疗指南2018[J].中华心血管病杂志, 2018, 46 (10):760-789.
[4] 杨瑞波, 信栓力.可溶性ST2在急性心肌梗死中的研究进展[J].临床心血管病杂志, 2018, 34 (2):202-206.
[5] Parikh RH, Seliger SL, Christenson R, et al.Soluble ST2for prediction of heart failure and cardiovascular death in an elderly, community-dwelling population[J].J Am Heart Assoc, 2016, 5 (8):e003188.
[6] 于海侠, 武丽珠, 刘海洋, 等.血清半乳糖凝集素3和可溶性ST2预测心肺复苏后急性心力衰竭患者近期预后的价值[J].临床心血管病杂志, 2018, 34 (8):786-789.
[7] Coglianese EE, Larson MG, Vasan RS, et al.Distribution and clinical correlates of the interleukin receptor family member soluble ST2in the Framingham Heart Study[J].Clin Chem, 2012, 58 (12):1673-1681.
[8] Ho JE, Larson MG, Ghorbani A, et al.Soluble ST2predicts elevated SBP in the community[J].J Hypertens, 2013, 31 (7):1431-1436.
[9] Ojji DB, Opie LH, Lecour S, et al.Relationship between left ventricular geometry and soluble ST2in a cohort of hypertensive patients[J].J ClinHypertens, 2013, 15 (12):899-904.
[10] Januzzi JL Jr, Peacock WF, Maisel AS, et al.Measurement of the interleukin family member ST2in patients with acute dyspnea:results from the PRIDE (ProBrain Natriuretic Peptide Investigation of Dyspnea in the Emergency Department)[J].J Am Coll Cardiol, 2007, 50 (7):607-613.
[11] Ojji DB, Opie LH, Lecour S, et al.The effect of left ventricular remodelling on soluble ST2in a cohort of hypertensive subjects[J].J Hum Hypertens, 2014, 28 (7):432-437.
[12] Wang YC, Yu CC, Chiu FC, et al.Soluble ST2as a biomarker for detecting stable heart failure with a normal ejection fraction in hypertensive patients[J].JCard Fail, 2013, 19 (3):163-168.
-
计量
- 文章访问数: 394
- PDF下载数: 152
- 施引文献: 0
下载: