Research progress in the relationship between oxidative stress and thrombotic disease
-
摘要: 氧化应激是机体氧化与抗氧化系统失衡引起,在多种疾病的发生发展过程中发挥重要作用。血栓性疾病是一种常见的心血管疾病,其发生过程与氧化应激密切相关。本文就近年来关于氧化应激相关标志物及信号通路与血栓性疾病关系的研究进行综述。Abstract: Oxidative stress is caused by imbalance between body oxidation and antioxidant system, and plays an important role in the occurrence and development of various diseases.Thrombotic disease is a common cardiovascular disease, which is closely related to oxidative stress.In this paper, recent studies on oxidative stress-related markers, signaling pathways and thrombotic diseases are reviewed.
-
Key words:
- oxidative stress /
- enzymes /
- signal pathway /
- thrombotic disease
-
-
[1] Westrick RJ, Eitzman DT.Plasminogen activator inhibitor-1in vascular thrombosis[J].Curr Drug Targets, 2007, 8 (9):966-1002.
[2] Aso Y.Plasminogen activator inhibitor (PAI) -1in vascular inflammation and thrombosis[J].Front Biosci, 2007, 12:2957-66.
[3] Raskob GE, Angchaisuksiri P, Blanco AN, et al.Thrombosis:a major contributor to global disease burden[J].Arterioscler Thromb Vasc Biol, 2014, 34 (11):2363-2371.
[4] 中国血栓性疾病防治指南专家委员会.中国血栓性疾病防治指南[J].中华医学杂志, 2018, (36):2861-2888.
[5] Schieber M, Chandel NS.ROS function in redox signaling and oxidative stress[J].Curr Biol, 2014, 24 (10):R453-462.
[6] Jacinto TA, Meireles GS, Dias AT, et al.Increased ROS production and DNA damage in monocytes are biomarkers of aging and atherosclerosis[J].Biol Res, 2018, 51 (1):33-33.
[7] Zorov DB, Juhaszova M, Sollott SJ.Mitochondrial reactive oxygen species (ROS) and ROS-induced ROSrelease[J].Physiol Rev, 2014, 94 (3):909-950.
[8] Sinha N, Dabla PK.Oxidative stress and antioxidants in hypertension-a current review[J].Curr Hypertens Rev, 2015, 11 (2):132-142.
[9] Montezano AC, Dulak-Lis M, Tsiropoulou S, et al.Oxidative stress and human hypertension:vascular mechanisms, biomarkers, and novel therapies[J].Can JCardiol, 2015, 31 (5):631-641.
[10] Del Rio L A.ROS and RNS in plant physiology:an overview[J].J Exp Bot, 2015, 66 (10):2827-2837.
[11] Busch CJ, Binder CJ.Malondialdehyde epitopes as mediators of sterile inflammation[J].Biochim Biophys Acta Mol Cell Biol Lipids, 2017, 1862 (4):398-406.
[12] Kim YW, Byzova TV.Oxidative stress in angiogenesis and vascular disease[J].Blood, 2014, 123 (5):625-631.
[13] Aizawa K, Takahari Y, Higashijima N, et al.Nicorandil prevents sirolimus-induced production of reactive oxygen species, endothelial dysfunction, and thrombus formation[J].J Pharmacol Sci, 2015, 127 (3):284-291.
[14] 赵冲宇, 王兵, 娄振凯, 等.深静脉血栓形成模型小鼠沉默信息调节因子1和氧化应激损伤标志物的表达[J].中国组织工程研究, 2018, 22 (28):4518-4524.
[15] Brandt M, Giokoglu E, Garlapati V, et al.Pulmonary arterial hypertension and endothelial dysfunction is linked to NADPH oxidase-derived superoxide formation in venous thrombosis and pulmonary embolism in mice[J].Oxid Med Cell Longev, 2018, 2018:1860513.
[16] Awad M A, Aldosari S R, Abid M R.Genetic alterations in oxidant and anti-oxidant enzymes in the vascular system[J].Front Cardiovasc Med, 2018, 5:107-107.
[17] 张军, 谷翔, 黄问银, 等.ROS调节mTOR信号通路参与自噬的研究进展[J].临床心血管病杂志, 2016, 32 (12):1266-1270.
[18] Feng Y, Liao S, Wei C, et al.Infiltration and persistence of lymphocytes during late-stage cerebral ischemia in middle cerebral artery occlusion and photothrombotic stroke models[J].J Neuroinflammation, 2017, 14 (1):248-248.
[19] Papac-Milicevic N, Busch CJ, Binder CJ.Malondialdehyde epitopes as targets of immunity and the implications for atherosclerosis[J].Adv Immunol, 2016, 131:1-59.
[20] Ferrante M, Fiore M, Conti GO, et al.Transition and heavy metals compared to oxidative parameter balance in patients with deep vein thrombosis:A case-control study[J].Mol Med Rep, 2017, 15 (5):3438-3444.
[21] Zhao Y, Chu X, Pang XB, et al.Antithrombotic effects of the effective components group of Xiaoshuantongluo formula in vivo and in vitro[J].Chin J Nat Med, 2015, 13 (2):99-107.
[22] Chen L, Jiang JQ, Zhang Y, et al.Experimental study on oral sulfhydryl as an adjuvant for improving nitrate ester tolerance in an animal model[J].Eur Rev Med Pharmacol Sci, 2018, 22 (5):1469-1477.
[23] Yang J, Yin HS, Cao YJ, et al.Arctigenin attenuates ischemia/reperfusion induced ventricular arrhythmias by decreasing oxidative stress in rats[J].Cell Physiol Biochem, 2018, 49 (2):728-742.
[24] 穆怀彬, 高峻, 林琳, 等.尼可地尔联合国产重组人脑利钠肽对AMI急诊PCI术后慢血流患者红细胞渗透脆性及氧化应激损伤的影响[J].临床心血管病杂志, 2019, 35 (1):83-87.
[25] Bhattacharyya A, Chattopadhyay R, Mitra S, et al.Oxidative stress:an essential factor in the pathogenesis of gastrointestinal mucosal diseases[J].Physiol Rev, 2014, 94 (2):329-354.
[26] Li H, Horke S, Forstermann U.Vascular oxidative stress, nitric oxide and atherosclerosis[J].Atherosclerosis, 2014, 237 (1):208-219.
[27] Bresciani G, Da Cruz I B, Gonzalez-Gallego J.Manganese superoxide dismutase and oxidative stress modulation[J].Adv Clin Chem, 2015, 68:87-130.
[28] Dayal S, Gu SX, Hutchins RD, et al.Deficiency of superoxide dismutase impairs protein C activation and enhances susceptibility to experimental thrombosis[J].Arterioscler Thromb Vasc Biol, 2015, 35 (8):1798-1804.
[29] 李兴国, 郑宏宇, 李文, 等.氧化应激和Rac1/2对静脉壁的影响及在创伤性深静脉血栓形成中的作用[J].中国组织工程研究, 2012, 20 (11):2033-2038.
[30] 姚律, 郝丽, 郭长策, 等.氧化应激相关酶及信号通路蛋白表达对动静脉内瘘患者血栓形成的影响[J].中国现代医学杂志, 2016, 26 (24):28-32.
[31] Imai N, Okabe T.Kinetics differ between copper-zinc and manganese superoxide dismutase activity with acute ischemic stroke[J].J Stroke Cerebrovasc Dis, 2011, 20 (1):75-78.
[32] Mehta SL, Lin Y, Chen W, et al.Manganese superoxide dismutase deficiency exacerbates ischemic brain damage under hyperglycemic conditions by altering autophagy[J].Transl Stroke Res, 2011, 2 (1):42-50.
[33] Wang Y, Wang W, Xu H, et al.Non-lethal sonodynamic therapy inhibits atherosclerotic plaque progression in ApoE-/-mice and attenuates ox-LDL-mediated macrophage impairment by inducing heme oxygenase-1[J].Cell Physiol Biochem, 2017, 41 (6):2432-2446.
[34] Gou L, Zhao L, Song W, et al.Inhibition of miR-92a suppresses oxidative stress and improves endothelial function by upregulating heme oxygenase-1in db/db mice[J].Antioxid Redox Signal, 2018, 28 (5):358-370.
[35] Gabre J, Chabasse C, Cao C, et al.Activated protein Caccelerates venous thrombus resolution through heme oxygenase-1induction[J].J Thromb Haemost, 2014, 12 (1):93-102.
[36] Zhao MY, Luo YP, Fei DS, et al.Molecular biologic study on heme oxygenase in experiment pulmonary thromboembolism[J].Zhongguo Wei Zhong Bing Ji Jiu Yi Xue, 2007, 19 (12):745-748.
[37] Li X, Song G, Jin Y, et al.Higher level of heme oxygenase-1in patients with stroke than TIA[J].J Thorac Dis, 2014, 6 (6):772-777.
[38] 吉庆伟, 吴帮卫, 曾秋棠, 等.HO-1调节Th17/Treg失衡延缓动脉粥样硬化进程的机制研究[J].临床心血管病杂志, 2016, 32 (2):188-192.
[39] Kishimoto Y, Sasaki K, Saita E, et al.Plasma heme oxygenase-1 levels and carotid atherosclerosis[J].Stroke, 2018, 49 (9):2230-2232.
[40] Liu DN, Fang Y, Wu LR, et al.Effect of the haeme oxygenase-1/endogenous carbon monoxide system on atherosclerotic plaque formation in rabbits[J].Cardiovasc J Afr, 2010, 21 (5):257-262.
[41] Chaudhari N, Talwar P, Parimisetty A, et al.A molecular web:endoplasmic reticulum stress, inflammation, and oxidative stress[J].Front Cell Neurosci, 2014, 8:213-213.
[42] Li G, Zhou R, Zhao X, et al.Correlation between the expression of IL18and deep venous thrombosis[J].Int J Mol Med, 2018, 42 (2):2972.
[43] 娄振凯.SIRT1保护内皮细胞氧化损伤, 抑制促血栓分子表达, 影响DVT形成的机制研究[J].昆明医科大学, 2016.
[44] Xu C, Tang F, Lu M, et al.Pretreatment with astragaloside IV protects human umbilical vein endothelial cells from hydrogen peroxide induced oxidative stress and cell dysfunction via inhibiting eNOS uncoupling and NADPH oxidase-ROS-NF-kappaB pathway[J].Can J Physiol Pharmacol, 2016, 94 (11):1132-1140.
[45] Tabassum R, Vaibhav K, Shrivastava P, et al.Perillyl alcohol improves functional and histological outcomes against ischemia-reperfusion injury by attenuation of oxidative stress and repression of COX-2, NOS-2and NF-kappaB in middle cerebral artery occlusion rats[J].Eur J Pharmacol, 2015, 747:190-199.
[46] Cheng L, Pan GF, Zhang XD, et al.Yindanxinnaotong, a Chinese compound medicine, synergistically attenuates atherosclerosis progress[J].Sci Rep, 2015, 5:12333.
[47] Sun J, Nan G.The Mitogen-Activated Protein Kinase (MAPK) signaling pathway as a discovery target in stroke[J].J Mol Neurosci, 2016, 59 (1):90-98.
[48] Liu Y, He C.A review of redox signaling and the control of MAP kinase pathway in plants[J].Redox Biol, 2017, 11:192-204.
[49] Yang M, Cooley BC, Li W, et al.Platelet CD36promotes thrombosis by activating redox sensor ERK5in hyperlipidemic conditions[J].Blood, 2017, 129 (21):2917-2927.
[50] Zhang Y, Li C, Meng H, et al.BYD Ameliorates oxidative stress-induced myocardial apoptosis in heart failure post-acute myocardial infarction via the P38MAPK-CRYAB signaling pathway[J].Front Physiol, 2018, 9:505.
[51] Yen TL, Chen RJ, Jayakumar T, et al.Andrographolide stimulates p38 mitogen-activated protein kinasenuclear factor erythroid-2-related factor 2-heme oxygenase 1signaling in primary cerebral endothelial cells for definite protection against ischemic stroke in rats[J].Transl Res, 2016, 170:57-72.
[52] Liu YY, Chiang CH, Hung SC, et al.Hypoxia-preconditioned mesenchymal stem cells ameliorate ischemia/reperfusion-induced lung injury[J].PLoS One, 2017, 12 (11):e0187637.
-
计量
- 文章访问数: 2836
- PDF下载数: 425
- 施引文献: 0