Galectin-3对非瓣膜性持续性心房颤动患者射频消融术后临床疗效的预测价值

彭智柯; 杨志明; 路申潞

doi:10.13201/j.issn.1001-1439.2020.08.013

Galectin-3对非瓣膜性持续性心房颤动患者射频消融术后临床疗效的预测价值

- 山西医科大学第二医院心血管内科(太原, 030001)

详细信息

通讯作者: 杨志明,E-mail:13935153583@139.com

中图分类号: R541.75

收稿日期: 2020-01-09

修回日期: 2020-03-17

Predictive value of Galectin-3 in the treatment of patients with non-valvular persistent atrial fibrillation after catheter ablation

- Department of Cardiology, the Second Hospital of Shanxi Medical University, Taiyuan, 030001, China

More Information

Corresponding author: YANG Zhiming, E-mail: 13935153583@139.com

Received Date: 09 January 2020

Revised Date: 17 March 2020

摘要

摘要: 目的:研究血清Galectin-3(Gal-3)在非瓣膜性持续性心房颤动(nPsAF)患者中的表达水平,探究Gal-3对nPsAF患者射频消融术后临床疗效的预测价值。方法:纳入50例nPsAF并初次行射频消融术的患者作为nPsAF组,52例健康人群作为健康对照组。记录心房颤动患者射频消融术前的一般资料以及血清Gal-3水平。随访1年,判断射频消融术后的复发情况并记录。结果:nPsAF组患者血清Gal-3明显高于健康对照组。在nPsAF组中射频消融术后复发者的血清Gal-3水平较未复发者明显升高。血清Gal-3和左房内径(LAD)是预测nPsAF射频消融术后复发的独立危险因素。结论:血清Gal-3在nPsAF患者中明显升高,且可独立预测nPsAF射频消融术后的复发,联合LAD预测价值更大。
- Galectin-3 /
- 心房颤动 /
- 射频消融 /
- 复发
Abstract: Objective:To investigate the expression level of serum Galectin-3(Gal-3)in patients with non-valvular persistent atrial fibrillation(nPsAF), and to explore the predictive value of Gal-3 in the clinical outcome of catheter ablation in patients with nPsAF. Method:Fifty patients with nPsAF who underwent initial radiofrequency ablation were enrolled and 52 healthy controls were included as controls. Clinical and laboratory data and serum Gal-3 levels before radiofrequency ablation were recorded in patients with nPsAF. After 1 year of follow-up, the recurrence after radiofrequency ablation was judged and recorded. Result:Serum Gal-3 was significantly higher in patients with nPsAF than in healthy controls. In the nPsAF group, the serum Gal-3 level was significantly increased in patients with recurrence after radiofrequency ablation compared with those without recurrence. Serum Gal-3 and left atrial diameter(LAD) are independent risk factors for predicting recurrence after radiofrequency ablation of nPsAF.Conclusion:Serum Gal-3 is significantly elevated in patients with nPsAF and can independently predict recurrence after radiofrequency ablation. Combined with LAD, serum Gal-3 has a greater predictive value.
- Galectin-3 /
- atrial fibrillation /
- catheter ablation /
- recurrence

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参考文献(20)

[1]	Morin DP,Bernard ML,Madias C,et al.The State of the Art:Atrial Fibrillation Epidemiology,Prevention,and Treatment[J].Mayo Clin Proc,2016,91(12):1778-1810.
[2]	Nicolas C,Eric P,Arnaud B,et al.Galectin-3 in Atrial Fibrillation:Mechanisms and Therapeutic Implications[J].Int J Mol Sci,2018,19(4).pii:E976.
[3]	Hua S,Jing W,Jie M,et al.Activation of TGF-β1/α-SMA/Col I Profibrotic Pathway in Fibroblasts by Galectin-3 Contributes to Atrial Fibrosis in Experimental Models and Patients[J].Cell Physiol Biochem,2018,47(2):851-863.
[4]	Nicolas C,Bruno G,André Clémentine,et al.Galectin-3 level predicts response to ablation and outcomes in patients with persistent atrial fibrillation and systolic heart failure[J].PLoS One,2018,13(8):e0201517.
[5]	Chen D,Procter N,Goh V,et al.New onset atrial fibrillation is associated with elevated Galectin-3 levels[J].Int J Cardiol,2016,223:48-49.
[6]	Nicolas C,Eric P,Arnaud B,Andre C,et al.Galectin-3 in Atrial Fibrillation:Mechanisms and Therapeutic Implications[J].Int J Mol Sci,2018,19(4).pii:E976.
[7]	王超.血清半乳凝集素-3对慢性心力衰竭的诊断价值[J].临床心血管病杂志,2019,35(11):1029-1032.
[8]	Takemoto Y,Ramirez RJ,Yokokawa M,Jalife J.Galectin-3 Regulates Atrial Fibrillation Remodeling and Predmts Catheter Ablation Outcomes[J].JACC Basic Transl Sci,2016,1(3):143-154.
[9]	Yu L,Ruifrok WP,Meissner M,et al.Genetic and Pharmacological Inhibition of Galectin-3 Prevents Cardiac Remodeling by Interfering With Myocardial Fibrogenesis[J].Circ Heart Fail,2013,6(1):107-117.
[10]	Chen D,Procter N,Goh V,et al.New onset atrial fibrillation is associated with elevated Galectin-3levels[J].Int J Cardiol,2016,223:48-49.
[11]	Löfsjögård J,Persson H,Díez J,et al.Atrial fibrillation and biomarkers of myocardial fibrosis in heart failure[J].Scand Cardiovasc J,2014,48(5):299-303.
[12]	赵欣,夏时俊,孙鹏瑜,等.miR-26通过负向调控AngⅡ/KLF4/TGF-β通路抑制心房颤动易感性及心房纤维化[J].临床心血管病杂志,2019,35(6):549-554.
[13]	ScharenbergMA,Pippenger BE,Sack R,et al.TGF-β-induced differentiation into myofibroblasts involves specific regulation of two MKL1 isoforms[J].J Cell Sci,2014,127(Pt5):1079-1091.
[14]	张国华.TGF-β1/Smads信号通路在高血压心肌纤维化中的调控机制研究进展[J].山东医药,2014,54(7):85-87.
[15]	Liao TD,Yang XP,D'Ambrosio M,et al.N-acetyl-seryl-aspartyl-lysyl-proline attenuates renal injury and dysfunction in hypertensive rats with reduced renal mass:council for high blood pressure research[J].Hypertension,2010,55(2):459-467.
[16]	González GE,Rhaleb NE,DAmbrosio MA,et al.Cardiac-deleterious role of Galectin-3in Angiotension IIinduced Hypertension[J].Am J Physiol Heart Circ Physiol,2016,311(5):H1287-H1296.
[17]	Lin YH,Chou CH,Wu XM,et al.Aldosterone Induced Galectin-3 Secretion In Vitro and In Vivo:From Cells to Humans[J].PLoS One,2014,9(9):e95254.
[18]	Fashanu OE,Norby FL,Aguilar D,et al.Galectin-3and Incidence of Atrial Fibrillation:the Atherosclerosis Risk in Communities(ARIC)Study[J].Am Heart J,2017,192:19-25.
[19]	Desmedt V,Desmedt S,Delanghe JR,et al.Galectin-3in renal pathology:More than just an innocen bystander[J].Am J Nephrol,2016,43(5):305-317.
[20]	Venteclef N,Guglielmi V,Balse E,et al.Human epicardial adipose tissue induces fibrosis of the atrial myocardium through the secretion of adipo-fibrokines[J].Eur Heart J,2015,36(13):795-805a.