Research progress in clinical pathology and imaging of coronavirus disease 2019-associated myocardial injury
-
摘要: 由新型冠状病毒(SARS-CoV-2)感染引起的新型冠状病毒肺炎(COVID-19)严重威胁人类健康。随着确诊病例数增加和研究深入,发现COVID-19主要侵犯呼吸系统,还可累及心肌及其他重要脏器。本文对COVID-19相关心肌损伤的病理生理学机制、临床特征、影像学评估等进行综述,以期为COVID-19患者心肌损伤的早期诊治及预后评估提供帮助。Abstract: Coronavirus disease 2019(COVID-19), caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), has posed a great threat to human health. With increase in the number of confirmed cases and gradual deepening of researches, people have found that COVID-19 can cause myocardial injury in addition to mainly affecting the respiratory system. This article will review recent progress in pathophysiological mechanisms, clinical features and imaging evaluation of COVID-19-associated myocardial injury, in order to provide help for early diagnosis and treatment, as well as prognosis evaluation.
-
[1] Wang D,Hu B,Hu C,et al.Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan,China[J].JAMA,2020,323(11):1061-1069.
[2] Lippi G,Lavie CJ,Sanchis-Gomar F.Cardiac troponin I in patients with coronavirus disease 2019(COVID-19):evidence from a meta-analysis[J].Prog Cardiovasc Dis,2020,63(3):390-391.
[3] Zou X,Chen K,Zou J,et al.Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection[J].Front Med,2020,14(2):185-192.
[4] Tavazzi G,Pellegrini C,Maurelli M,et al.Myocardial localization of coronavirus in COVID-19 cardiogenic shock[J].Eur J Heart Fail,2020,22(5):911-915.
[5] Cooper LT Jr.Myocarditis[J].N Engl J Med,2009,360(15):1526-1538.
[6] Jia HP,Look DC,Tan P,et al.Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia[J].Am J Physiol Lung Cell Mol Physiol,2009,297(1):L84-96.
[7] Jaimes JA,Andre NM,Chappie JS,et al.Phylogenetic analysis and structural modeling of SARS-CoV-2 spike protein reveals an evolutionary distinct and proteolytically sensitive activation loop[J].J Mol Biol,2020,432(10):3309-3325.
[8] Freeman EJ,Chisolm GM,Ferrario CM,et al.Angiotensin-(1-7) inhibits vascular smooth muscle cell growth[J].Hypertension,1996,28(1):104-108.
[9] McCollum LT,Gallagher PE,Tallant EA.Angiotensin-(1-7) abrogates mitogen-stimulated proliferation of cardiac fibroblasts[J].Peptides,2012,34(2):380-388.
[10] Rapkiewicz AV,Mai X,Carsons SE,et al.Megakaryocytes and platelet-fibrin thrombi characterize multi-organ thrombosis at autopsy in COVID-19:a case series[J].EClinicalMedicine,2020,24:100434.
[11] Tang N,Li D,Wang X,et al.Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia[J].J Thromb Haemost,2020,18(4):844-847.
[12] Escher R,Breakey N,Lammle B.Severe COVID-19 infection associated with endothelial activation[J].Thromb Res,2020,190:62.
[13] Cameron MJ,Ran L,Xu L,et al.Interferon-mediated immunopathological events are associated with atypical innate and adaptive immune responses in patients with severe acute respiratory syndrome[J].J Virol,2007,81(16):8692-8706.
[14] Huang C,Wang Y,Li X,et al.Clinical features of patients infected with 2019 novel coronavirus in Wuhan,China[J].Lancet,2020,395(10223):497-506.
[15] Zheng YY,Ma YT,Zhang JY,et al.COVID-19 and the cardiovascular system[J].Nat Rev Cardiol,2020,17(5):259-260.
[16] Zhao X,Nicholls JM,Chen YG.Severe acute respiratory syndrome-associated coronavirus nucleocapsid protein interacts with Smad3 and modulates transforming growth factor-beta signaling[J].J Biol Chem,2008,283(6):3272-3280.
[17] Belhadjer Z,Meot M,Bajolle F,et al.Acute heart failure in multisystem inflammatory syndrome in children(MIS-C)in the context of global SARS-CoV-2 pandemic[J].Circulation,2020,142(5):429-436.
[18] Hedrich CM.COVID-19-considerations for the paediatric rheumatologist[J].Clin Immunol,2020,214:108420.
[19] Barbour JR,Spinale FG,Ikonomidis JS.Proteinase systems and thoracic aortic aneurysm progression[J].J Surg Res,2007,139(2):292-307.
[20] Guo T,Fan Y,Chen M,et al.Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019(COVID-19)[J].JAMA Cardiol,2020,5(7):811-818.
[21] Sperotto F,Friedman KG,Son MBF,et al.Cardiac manifestations in SARS-CoV-2-associated multisystem inflammatory syndrome in children:a comprehensive review and proposed clinical approach[J].Eur J Pediatr,2020,Aug 15.DOI:10.1007/s00431-020-03766-6.
[22] 陈晨,陈琛,严江涛,等.新型冠状病毒肺炎危重型患者心肌损伤及患有心血管基础疾病的情况分析[J].中华心血管病杂志,2020,48(7):567-571.
[23] Kang Y,Chen T,Mui D,et al.Cardiovascular manifestations and treatment considerations in COVID-19[J].Heart,2020,106(15):1132-1141.
[24] Giustino G,Croft LB,Stefanini GG,et al.Characterization of myocardial injury in patients with COVID-19[J].J Am Coll Cardiol,2020,76(18):2043-2055.
[25] Inciardi RM,Lupi L,Zaccone G,et al.Cardiac involvement in a patient with coronavirus disease 2019(COVID-19)[J].JAMA Cardiol,2020,5(7):819-824.
[26] Stefanini GG,Montorfano M,Trabattoni D,et al.ST-elevation myocardial infarction in patients with COVID-19:clinical and angiographic outcomes[J].Circulation,2020,141(25):2113-2116.
[27] Vieillard-Baron A,Prin S,Chergui K,et al.Echo-Doppler demonstration of acute cor pulmonale at the bedside in the medical intensive care unit[J].Am J Respir Crit Care Med,2002,166(10):1310-1319.
[28] Logstrup BB,Nielsen JM,Kim WY,et al.Myocardial oedema in acute myocarditis detected by echocardiographic 2D myocardial deformation analysis[J].Eur Heart J Cardiovasc Imaging,2016,17(9):1018-1026.
[29] Pastore MC,Mandoli GE,Aboumarie HS,et al.Basic and advanced echocardiography in advanced heart failure:an overview[J].Heart Fail Rev,2020,25(6):937-948.
[30] Stobe S,Richter S,Seige M,et al.Echocardiographic characteristics of patients with SARS-CoV-2 infection[J].Clin Res Cardiol,2020,109(12):1549-1566.
[31] Ferreira VM,Schulz-Menger J,Holmvang G,et al.Cardiovascular magnetic resonance in nonischemic myocardial inflammation:expert recommendations[J].J Am Coll Cardiol,2018,72(24):3158-3176.
[32] Mavrogeni S,Apostolou D,Argyriou P,et al.T1 and T2 mapping in cardiology:"mapping the obscure object of desire"[J].Cardiology,2017,138(4):207-217.
[33] Kim RJ,Albert TS,Wible JH,et al.Performance of delayed-enhancement magnetic resonance imaging with gadoversetamide contrast for the detection and assessment of myocardial infarction:an international,multicenter,double-blinded,randomized trial[J].Circulation,2008,117(5):629-637.
[34] Gravinay P,Issa N,Girard D,et al.CMR and serology to diagnose COVID-19 infection with primary cardiac involvement[J].Eur Heart J Cardiovasc Imaging,2021,22(1):133.
[35] Huang L,Zhao P,Tang D,et al.Cardiac involvement in patients recovered from COVID-2019 identified using magnetic resonance imaging[J].JACC Cardiovasc Imaging,2020,13(11):2330-2339.
[36] Pontone G,Baggiano A,Conte E,et al."Quadruple rule-out" with computed tomography in a COVID-19 patient with equivocal acute coronary syndrome presentation[J].JACC Cardiovasc Imaging,2020,13(8):1854-1856.
[37] Wang M,Cao R,Zhang L,et al.Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus(2019-nCoV)in vitro[J].Cell Res,2020,30(3):269-271.
[38] Shen C,Wang Z,Zhao F,et al.Treatment of 5 critically ill patients with COVID-19 with convalescent plasma[J].JAMA,2020,323(16):1582-1589.
[39] Cameli M,Pastore MC,Soliman Aboumarie H,et al.Usefulness of echocardiography to detect cardiac involvement in COVID-19 patients[J].Echocardiography,2020,37(8):1278-1286.
[40] Knight DS,Kotecha T,Razvi Y,et al.COVID-19:myocardial injury in survivors[J].Circulation,2020,142(11):1120-1122.
[41] Puntmann VO,Carerj ML,Wieters I,et al.Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019(COVID-19)[J].JAMA Cardiol,2020,5(11):1265-1273.
计量
- 文章访问数: 482
- PDF下载数: 84
- 施引文献: 0