长链非编码RNA在冠状动脉慢性完全闭塞病变的应用展望

尹亮; 甘露; 史博群; 刘德敏; 谷国强

doi:10.13201/j.issn.1001-1439.2021.02.017

长链非编码RNA在冠状动脉慢性完全闭塞病变的应用展望

- 1 河北医科大学第二医院河北省心脑血管研究所心内科(石家庄, 050000);
- 2 四川大学华西医院急诊医学研究室&急诊科
基金项目:
河北省自然科学基金项目(No:H2018206066

H2020206409)

中国心血管健康联盟-心馨-默克心血管科研基金(No:2017-CCA-xinxin merck fund-0011)

详细信息

通讯作者: 谷国强,E-mail:guguoqiang72@163.com

中图分类号: R541.4

收稿日期: 2020-08-11

Application prospect of long non-coding RNA in chronic total occlusion

- 1 Department of Cardiology, The Second Hospital of Hebei Medical University and Institude of Cardiocerebrovascular Disease of Hebei Province, Shijiazhuang, 050000, China;
- 2 Emergency Medical Laboratory & Department of Emergency, West China Hospital, Sichuan University

More Information

Corresponding author: GU Guoqiang, E-mail: guguoqiang72@163.com

Received Date: 11 August 2020

摘要

摘要: 冠状动脉慢性完全闭塞病变(CTO)已成为冠心病介入治疗中的热点之一。寻找敏感并特异的外周血生物标志物,用于高危CTO人群的早期筛查,将有助于该疾病的预测和治疗。近年来研究表明,长链非编码RNA被认为是心血管危险因素和细胞功能的重要调节因子,因此其可能是CTO诊断和预后评估的重要指标之一。本文旨在对长链非编码RNA与CTO发生发展的关系,以及长链非编码RNA在CTO中潜在的应用价值进行综述。
- 慢性完全闭塞病变 /
- 长链非编码RNA /
- 冠心病
Abstract: Chronic total occlusion(CTO) has become one of the hotspots in interventional treatment of coronary artery disease. We look for sensitive and specific peripheral blood biomarkers for the early screening of high-risk CTO population, which will help the prediction and treatment of the disease. Recent studies have shown that long non-coding RNA(lncRNA) is considered to be an important regulator of cardiovascular risk factors and cell function, so it may be one of the important indicators for the diagnosis and prognostic assessment of CTO. This article reviews the relationship between lncRNA and the development of CTO, as well as the potential application value of lncRNA in CTO.
- chronic total occlusion /
- long non-coding RNA /
- coronary artery disease

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