N端脑钠肽前体、可溶性人基质裂解素2及血小板/淋巴细胞比值对慢性心力衰竭的诊断价值

乾叶子; 杨威; 吕媛媛; 赵瑞毓; 张明高; 秦梦云; 韩红彦

doi:10.13201/j.issn.1001-1439.2021.03.011

N端脑钠肽前体、可溶性人基质裂解素2及血小板/淋巴细胞比值对慢性心力衰竭的诊断价值

- 武汉科技大学附属天佑医院心内科(武汉, 430065)
基金项目:
湖北省教委科研基金(No:B2018001)

详细信息

通讯作者: 韩红彦,E-mail:hhy2009218@163.com

中图分类号: R541.6

收稿日期: 2020-10-24

修回日期: 2020-11-15

The diagnostic value of N-terminal pro-brain natriuretic peptide, soluble human stromelysin-2 and platelet-lymphocyte ratio in chronic heart failure

- Department of Cardiology, Tianyou Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, 430065, China

More Information

Corresponding author: HAN Hongyan, E-mail: hhy2009218@163.com

Received Date: 24 October 2020

Revised Date: 15 November 2020

摘要

摘要: 目的:探讨N端脑钠肽前体(NT-proBNP)、可溶性人基质裂解素2(sST2)、血小板/淋巴细胞比值(PLR)三者联合检测在慢性心力衰竭(CHF)患者中的诊断价值。方法:选取我院128例CHF患者作为CHF组,并根据左室射血分数(LVEF)将其分为射血分数降低(HFrEF,LVEF<40%,48例)、射血分数中间值(HFmrEF,LVEF 40%~49%,52例)和射血分数保留(HFpEF,LVEF≥50%,28例)3个亚组。选取43例健康体检者为对照组。统计分析CHF组与对照组、CHF组不同亚组间NT-proBNP、sST2、PLR水平差异;二元Logistic回归分析CHF的危险因素;应用ROC曲线分析NT-proBNP、sST2、PLR及三指标联合对CHF的诊断价值。结果:与对照组相比,CHF组NT-proBNP、sST2、PLR水平明显升高,且各亚组的NT-proBNP、sST2、PLR水平均存在显著差异(P<0.05)。二元Logistic回归提示NT-proBNP升高、sST2升高、PLR升高是CHF的独立危险因素(均P<0.05)。NT-proBNP、sST2、PLR三者诊断CHF的曲线下面积(AUC)分别为0.867、0.859、0.798,三者联合应用诊断CHF的AUC为0.978。结论:CHF患者血NT-proBNP、sST2、PLR水平升高,三者联合应用能够提高对CHF的诊断价值。
- 慢性心力衰竭 /
- N端脑钠肽前体 /
- 可溶性人基质裂解素2 /
- 血小板/淋巴细胞比值
Abstract: Objective: To investigate the diagnostic value of N-terminal pro-brain natriuretic peptide(NT-proBNP), soluble human stromelysin-2(sST2), and platelet-lymphocyte ratio(PLR) in patients with chronic heart failure(CHF).Methods: We selected 128 patients with CHF in our hospital as the CHF group. The CHF group was further divided into 3 subgroups according to the left ventricular ejection fraction(LVEF): reduced ejection fraction(HFrEF, LVEF<40%,n=48), mid-range ejection fraction(HFmrEF, LVEF 40%-49%, n=52) and preserved ejection fraction(HFpEF, LVEF≥50%, n=28). Other 43 healthy subjects were selected as the control group. Statistical analysis was conducted on the differences of NT-proBNP, sST2, PLR levels among the 3 subgroups in the CHF group and control group. Binary Logistic regression was used to analyze the risk factors of CHF. ROC curve was employed to analyze the diagnostic value of NT-proBNP, sST2, PLR alone and the combination of three indexes in CHF.Results: Compared with the control group, the CHF group had significantly higher levels of NT-proBNP, sST2, and PLR than those in the control group. Moreover, the levels of NT-proBNP, sST2, and PLR among each subgroup were significantly different. Binary Logistic regression showed that elevated PLR, NT-proBNP, and sST2 were independent risk factors for CHF. The areas under the curve of NT-proBNP, sST2, and PLR in CHF diagnosis were 0.867, 0.859, and 0.798, respectively, whereas the area under the curve of combined application of the three indexes in the diagnosis of CHF was 0.978.Conclusion: The serum levels of NT-proBNP, sST2 and PLR in patients with CHF are increased, and the combined application of the three indexes can improve the diagnostic value for CHF.
- chronic heart failure /
- N-terminal pro-brain natriuretic peptide /
- soluble human stromelysin-2 /
- platelet-lymphocyte ratio

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