基于数据挖掘探讨应激性心肌病临床特点及住院死亡危险因素

陈俊; 吕玲春; 沈珈谊; 韦铁民

doi:10.13201/j.issn.1001-1439.2021.06.012

基于数据挖掘探讨应激性心肌病临床特点及住院死亡危险因素

- 1. 浙江大学丽水医院心内科(浙江丽水,323000);
- 2. 浙江大学医学院
基金项目:
浙江省基础公益研究计划(No:LGF19H020008)

丽水市公益计划(No:2019GYX28)

详细信息

通讯作者: 韦铁民,E-mail:lswtm@sina.com

中图分类号: R542.2

收稿日期: 2020-10-08

Analysis of clinical characteristics and in-hospital death risk factors of Takotsubo syndrome based on data mining

- 1. Department of Cardiology,Lishui Hospital of Zhejiang University, Lishui, Zhejiang, 323000, China;
- 2. Zhejiang University School of Medicine

More Information

Corresponding author: WEI Tiemin, E-mail: lswtm@sina.com

Received Date: 08 October 2020

摘要

摘要: 目的:探讨应激性心肌病(TTS)临床特点及住院死亡危险因素。方法:对美国重症监护室数据库(MIMIC-Ⅲ数据库)诊断为TTS患者的临床资料(包括人口学特征、实验室检查及心脏超声数据)进行回顾性分析。根据生存预后,将患者分为存活组和死亡组,对两组的基线资料进行比较,采用单因素回归分析挖掘可能的危险因素,多因素逐步前向回归分析确定住院死亡危险因素。结果:从MIMIC-Ⅲ数据库中共提取TTS患者56例,其中男6例,女50例,平均年龄64.2岁。住院期间死亡6例(10.7%)。单因素回归分析显示,呼吸衰竭(OR:15.83,95%CI:1.68~149.17,P=0.016)、红细胞比容(OR:0.05,95%CI:0.01~0.42,P=0.006)、血红蛋白(OR:0.08,95%CI:0.02~0.42,P=0.003)、估算血浆容量状态(OR:3.46,95%CI:1.61~7.46,P=0.002)及乳酸脱氢酶(OR:1.31,95%CI:1.10~1.56,P=0.002)是TTS患者住院死亡的危险预测因子;多因素逐步前向回归分析确认估算血浆容量状态(OR:1.49,95%CI:1.17~1.89,P=0.002)与乳酸脱氢酶(OR:1.0003,95%CI:1.0002~1.0005,P<0.001)是TTS患者住院死亡的危险因素。结论:估算血浆容量状态和乳酸脱氢酶升高是TTS住院死亡危险因素。
- 应激性心肌病 /
- 住院死亡 /
- 血浆容量状态 /
- 乳酸脱氢酶
Abstract: Objective: To explore the clinical features and risk factors of in-hospital death of Takotsubo syndrome(TTS).Methods: A retrospective analysis was made in TTS patients included in American intensive care unit database(MIMIC-Ⅲ database). The clinical data included demographic characteristics, laboratory tests, and echocardiography findings. Patients were divided into survival group and death group according to prognosis. The baseline data between the two groups were compared. Univariate regression analysis was used to explore the possible risk factors and multivariate stepwise forward regression analysis was used to determine the risk factors of in-hospital death.Results: A total of 56 patients diagnosed as TTS were extracted from MIMIC-Ⅲ database, including 6 males and 50 females, with an average age of 64.2 years. Six patients died during hospitalization and the mortality was 10.7%. Univariate regression analysis suggested that respiratory failure(OR: 15.83, 95%CI: 1.68-149.17, P=0.016), hematocrit(OR: 0.05, 95%CI: 0.01-0.42, P=0.006), hemoglobin(OR: 0.08, 95%CI: 0.02-0.42, P=0.003), estimated plasma volume status(OR: 3.46, 95%CI: 1.61-7.46, P=0.002), and lactate dehydrogenase(OR: 1.31, 95%CI: 1.10-1.56, P=0.002) were the potential risk factors of in-hospital death for TTS patients. Multivariate regression analysis identified that estimated plasma volume status(OR: 1.49, 95%CI: 1.17-1.89, P=0.002) and lactate dehydrogenase(OR: 1.0003, 95%CI: 1.0002-1.0005, P<0.001) were the risk factors of in-hospital death for TTS patients.Conclusion: Estimated plasma volume status and elevated lactate dehydrogenase are the risk factors of in-hospital death for TTS patients.
- Takotsubo syndrome /
- in-hospital death /
- estimated plasma volume status /
- lactate dehydrogenase

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