和田地区维吾尔族早发急性冠状动脉综合征危险因素研究

周世英; 牛伟华; 安玉楠; 李超; 何强; 许梦萍; 叶绪英; 卡地尔·依米提; 卢成志

doi:10.13201/j.issn.1001-1439.2021.07.005

和田地区维吾尔族早发急性冠状动脉综合征危险因素研究

- 1. 天津医科大学研究生院(天津, 300070);
- 2. 新疆和田地区人民医院心内科;
- 3. 天津市第一中心医院心内科
基金项目:
国家自然科学基金项目(No:81970303)

详细信息

通讯作者: 卢成志,E-mail:lucz8@126.com

中图分类号: R541.4

收稿日期: 2021-01-17

Risk factors of early-onset acute coronary syndrome in Uygur nationality in Hotan district

- 1. Graduate School of Tianjin Medical University, Tianjin, 300070, China;
- 2. Department of Cardiology,People's Hospital of Hotan District in Xinjiang;
- 3. Department of Cardiology,the First Central Hospital of Tianjin

More Information

Corresponding author: LU Chengzhi, E-mail: lucz8@126.com

Received Date: 17 January 2021

摘要

摘要: 目的:探讨新疆和田维吾尔族早发急性冠状动脉综合征(ACS)患者的临床特点及危险因素。方法:收集2017—2020年在新疆和田地区人民医院心内科住院的维吾尔族早发ACS患者264例(男性年龄≤45岁,女性≤55岁),同时收集同期的非早发ACS患者254例(男性年龄>55岁,女性>65岁),比较两组患者的临床基本特征、发病类型、冠状动脉(冠脉)造影特点。结果:①两组早发ACS均以男性为主,但早发ACS组患者女性比例(78/264,29.5%)显著高于非早发组(25/254,9.8%)(P<0.05)。早发组的体质指数、吸烟史、饮酒史、冠心病家族史以及合并有高血压的比例明显高于非早发组(P<0.05);非早发组合并有糖尿病、脑梗死病史的比例高于早发组(P<0.05);②早发组中血小板计数、甘油三酯、同型半胱氨酸的水平高于非早发组(P<0.05);非早发组中红细胞分布宽度、高密度脂蛋白胆固醇高于早发组(P<0.05);③发病类型上非早发ACS中心肌梗死的比例比早发ACS中更高,早发ACS中不稳定型心绞痛的比例比非早发ACS高(P<0.05);④早发ACS以单支病变为主,非早发ACS以3支病变为主;非早发ACS左主干、前降支、回旋支、右冠所占的比例均高于早发ACS(P<0.05)。⑤多因素logistic回归分析显示,吸烟、冠心病家族史、体质指数、血小板计数高、高密度脂蛋白胆固醇、高同型半胱氨酸是早发ACS的主要危险因素。结论:超重、吸烟、冠心病家族史、高同型半胱氨酸、血小板计数增高、高密度脂蛋白胆固醇是和田地区维吾尔族早发ACS的主要危险因素,冠脉血管病变特点上早发ACS患者以单支病变为主,非早发ACS以3支病变为主。
- 急性冠状动脉综合征 /
- 早发 /
- 维吾尔族 /
- 危险因素
Abstract: Objective: To explore the clinical features and risk factors of early-onset acute coronary syndrome(ACS) in Uyghurs in Hotan district, Xinjiang.Methods: A total of 264 Uyghur patients with early-onset ACS(male ≤45 years old, female ≤55) were collected, and 254 non-early-onset ACS patients in the same period were collected(male>55 years old, female>65 years old) in this study. We compared the basic clinical characteristics, disease type, and coronary angiography characteristics.Results: Early-onset ACS were mainly men in both groups, but the proportion of women in the early-onset ACS group(78/264, 29.5%) was significantly higher than that in the non-early-onset group(25/254, 9.8%)(P<0.05). The proportion of body mass index(BMI), smoking history, drinking history, family history of coronary heart disease, and hypertension in the early-onset group were significantly higher than those of the non-early-onset group(P<0.05); the proportion of history of diabetes and cerebral infarction in the non-early-onset group were higher than the early-onset group(P<0.05). The platelet count, triglyceride, and homocysteine levels in the early-onset group were higher than those in the non-early onset group(P<0.05); the red blood cells distribution width and high-density lipoprotein cholesterol in the non-early onset group were higher than those in the early-onset group(P<0.05). The proportion of myocardial infarction in non-early onset ACS was higher than that in early onset ACS, and the proportion of unstable angina in early onset ACS was higher than that in non-early-onset ACS(P<0.05). Early-onset ACS is dominated by single-vessel lesions, and non-early-onset ACS is dominated by three-vessel lesions; The proportions of the left main stem, anterior descending branch, circumflex branch, and right crown of non-early onset ACS were higher than those of early onset ACS(P<0.05). Binary logistic regression analysis showed that smoking, family history of cardiovascular disease, high BMI, high platelet count, low high-density lipoprotein cholesterol, and high homocysteine were the main risk factors for early onset of ACS.Conclusion: BMI, smoking, family history of coronary heart disease, high homocysteine, increased platelet count, and high-density lipoprotein cholesterol are the main risk factors for early-onset ACS in Uyghurs in Hotan area. Early-onset ACS patients are mainly single-vessel disease, and non-early-onset ACS are mainly three-vessel disease.
- early-onset acute coronary syndrome /
- Uyghur nationality /
- risk factors /

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