Preliminary study on the correlation between different blood lipids and coronary artery disease
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摘要: 目的:探讨不同血脂成分与患者冠状动脉病变的相关性,识别预测冠状动脉病变的最佳血脂指标。方法:入选因胸痛行冠状动脉造影检查的患者,根据造影结果将患者分为冠状动脉正常组(对照组,123例)和冠心病组(366例),进而依据Gensini积分将冠心病组分为轻度病变亚组(Gensini评分<30,177例)、重度病变亚组(Gensini评分≥30,189例)。检测各组患者的TC、TG、LDL-C、HDL-C、ApoA-1、ApoB等指标,计算non-HDL-C、TC/HDL-C、LDL-C/HDL-C、ApoB/ApoA-1等,并进行统计分析。结果:①与对照组相比,冠心病组患者ApoA-1水平显著降低,而ApoB/ApoA-1显著升高,差异均有统计学意义(P<0.05)。②多因素logistic回归分析结果提示年龄、糖尿病、吸烟、ApoB/ApoA-1是冠心病的独立危险因素;年龄、糖尿病、吸烟、ApoB/ApoA-1是冠状动脉重度病变的独立危险因素,ApoA-1是冠心病、冠状动脉重度病变的独立保护因素。③相关性分析结果表明ApoA-1与Gensini积分、冠状动脉病变血管数之间呈负相关(分别r=-0.367,r=-0.341,均P<0.01),ApoB/ApoA-1与Gensini积分、冠状动脉病变血管数之间呈正相关(分别r=0.371,r=0.350,均P<0.01)。(4)ROC曲线分析结果显示,ApoB/ApoA-1、ApoA-1对冠心病及冠状动脉重度病变具有一定的预测价值,相较其他血脂指标其预测价值较强。结论:相较于其他血脂指标,ApoA-1、ApoB/ApoA-1与冠心病发生发展的相关性最强。
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关键词:
- 载脂蛋白A-1 /
- 载脂蛋白B/载脂蛋白A-1 /
- Gensini积分 /
- 冠心病
Abstract: Objective: To explore the correlation between different blood lipid components and patients with coronary artery disease, and identify the best blood lipid index for predicting coronary artery disease.Methods: Patients who were selected for coronary angiography due to chest pain were divided into normal coronary artery group(control group, Gensini score=0, n=123) and coronary heart disease group(n=366) according to the results of the angiography, and then according to Gensini scores Coronary heart disease was divided into the subgroup of mild disease(Gensini score<30, n=177) and the subgroup of severe disease(Gensini score≥30, n=189). Detect TC, TG, LDL-C, HDL-C, ApoA-1, ApoB and other indicators of each group of patients, and calculate non-HDL-C, TC/HDL-C, LDL-C/HDL-C, ApoB/ApoA-1. AI, AIP, LCI.Results:① Compared with the control group, the levels of ApoA-1 in the coronary heart disease group were significantly reduced, while ApoB/ApoA-1 were significantly increased(P<0.05).② Multivariate logistic regression analysis suggested that age, diabetes, smoking, and ApoB/ApoA-1 were independent risk factors for coronary heart disease, and age, diabetes, smoking, and ApoB/ApoA-1 were independent risk factors for severe coronary artery disease. ApoA-1 was an independent protective factor for coronary heart disease and severe coronary artery disease.③ The results of correlation analysis showed that ApoA-1 was negatively correlated with Gensini score and the number of coronary artery diseased blood vessels(r=-0.367, r=-0.341, P<0.01), ApoB/ApoA-1 was a positive correlation with Gensini score and the number of coronary artery diseased vessels(r=0.371, r=0.350, respectively, P<0.01).(4) ROC curve analysis results showed that ApoB/ApoA-1 and ApoA-1 have certain predictive values for coronary heart disease and severe coronary artery disease, and their predictive value were stronger than other blood lipid indexes.Conclusion: Compared with other blood lipid indexes, ApoA-1, ApoB/ApoA-1 have the strongest correlation with coronary heart disease. -
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