Relationship between serum NT-pro-BNP and myocardial ischemia in patients with chronic coronary syndrome
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摘要: 目的:分析慢性冠状动脉综合征(CCS)患者血浆氨基末端B型脑钠肽前体(NT-pro-BNP)水平与心肌缺血的关系。方法:入选患者共92例,均行负荷动态CT心肌灌注成像(CT-MPI),根据CT结果分为灌注正常68例(A组),灌注异常24例(B组)。收集并比较2组数据。心肌缺血影响因素采用单因素及多因素二元Logistic回归分析。采用ROC曲线分析NT-pro-BNP对心绞痛患者灌注结果的预测价值。结果:相较灌注正常的患者,灌注异常的患者血浆NT-pro-BNP浓度更高,其差异有显著意义(P<0.05)。血浆NT-pro-BNP水平与患者缺血程度呈正相关(r=0.485,P<0.05)。当NT-pro-BNP的截断值为94.68 pg/mL时,其诊断灌注异常的曲线下面积(AUC)为0.802,灵敏度为75.0%,特异度为70.6%。结论:对于CCS患者而言,NT-pro-BNP可作为评估心肌缺血的有效补充生物标志物。
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关键词:
- 心肌缺血 /
- 心肌灌注 /
- 氨基末端B型脑钠肽前体
Abstract: Objective: To analyze the relationship between serum NT-pro-BNP level and myocardial ischemia in patients with chronic coronary syndrome(CCS).Methods: A total of 92 patients were enrolled, and all patients underwent dynamic CT myocardial perfusion imaging(CT-MPI). According to the CTP results, the patients were divided into normal perfusion group(group A, n=68) and abnormal perfusion group(group B, n=24). The data between the two groups were collected and compared. The impact factors of myocardial ischemia were assessed in univariate and multivariate analysis with binary logistic regression.Results: Compared with patients with normal perfusion, patients with abnormal perfusion have significant higher serum NT-pro-BNP level(P<0.05). Serum NT-pro-BNP level was positively correlated with the severity of ischemia(r=0.450, P<0.05). When cutoff value of NT-pro-BNP was 94.68 pg/ml, the area under the curve(AUC) of NT-pro-BNP in predicting myocardial perfusion was 0.802, the sensitivity were 75.0%, the specificity was 70.6%, respectively.Conclusion: NT-pro-BNP is an effective additional biomarker for the diagnosis of myocardial ischemia in patients with CCS. -
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