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摘要: 肥厚型心肌病患者左心室流出道梗阻会增加不良结局的风险，疾病进展可能会出现严重的运动受限、心律失常和过早死亡。Aficamte是一种新型心脏肌球蛋白抑制剂，aficamten可抑制心脏肌节的过度收缩，改善肥厚型心肌病患者的心室肥厚，减轻左室流出道梗阻，进而改善心脏功能。本文主要阐述心脏肌球蛋白抑制剂aficamten在肥厚型心肌病防治方面的最新研究进展，为肥厚型心肌病的治疗提供新思路。Abstract: The presence of left ventricular outflow tract obstruction in patients with hypertrophic cardiomyopathy increases the risk of adverse outcomes. Disease progression may result in severe exercise limitation, cardiac arrhythmias, and premature death. Aficamten(CK-274) is a cardiac myosin inhibitor. Aficamten inhibits excessive contraction of cardiac muscle segments, improves ventricular hypertrophy in patients with hypertrophic cardiomyopathy, reduces left ventricular outflow tract obstruction, and thus improves cardiac function. The latest research progress of cardiac myosin inhibitor aficamten in the prevention and treatment of hypertrophic cardiomyopathy is described in the paper, which provides new ideas for the treatment of hypertrophic cardiomyopathy.
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Key words:
- aficamten /
- CK-274 /
- myosin inhibitors /
- hypertrophic cardiomyopathy
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