The evidence-based path of perioperative anticoagulation therapy for acute coronary syndrome
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摘要: 抗栓治疗是急性冠状动脉综合征药物治疗的基石，围术期抗凝治疗对于预防血栓形成和降低缺血事件风险至关重要。自二十世纪九十年代以来，国际上围绕急性冠状动脉综合征患者冠状动脉介入术前、术中、术后乃至稳定期和慢性期开展了大量循证医学研究，为指导科学合理用药打下了坚实的证据基础。深入了解抗凝药物的药理特性，充分了解和正确评价临床研究结果，动态评估患者的缺血和出血风险，并结合冠状动脉病变和介入操作和并发症等情况，有利于及时调整抗栓治疗方案，从而实现安全抗栓和最大获益。Abstract: Antithrombotic therapy is the cornerstone of drug treatment for acute coronary syndrome, and perioperative anticoagulant therapy is crucial for preventing thrombosis and reducing the risk of ischemic events. Since the 1990 s, a large number of evidence-based studies have been conducted internationally on patients with acute coronary syndrome before, during, and after coronary intervention, and even in the stable and chronic phases, laying a solid evidence foundation for guiding scientific and rational drug use. In-depth understanding of the pharmacological properties of anticoagulants, full understanding and correct evaluation of clinical research results, dynamic assessment of patients' ischemic and bleeding risks, and combined with coronary artery lesions, interventional procedures, and complications will help to timely adjust antithrombotic treatment plans, thereby achieving safe antithrombotic treatment and maximum benefit.
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Key words:
- acute coronary syndrome /
- anticoagulation therapy /
- perioperative
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