Limitations and challenges of echocardiographic assessment of left ventricular ejection fraction
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摘要: 左心室射血分数(left ventricular ejection fraction,LVEF)作为心力衰竭诊断、治疗决策及疗效评估的核心参数,无论是基础研究还是临床应用,其测值的准确性具有极其重要的作用与价值。超声心动图是无创性评估LVEF的首选工具,但在实际应用中,由于存在技术本身局限性、操作者经验与临床应用场景限制等多种原因,其测值极易产生误差,甚至是重大差误,从而导致错误的诊断、错误的决策和错误的结论。本文对LVEF测值误差的来源进行了分析,对其质控进行了讨论,并对其未来的发展进行了展望。随着多模态影像综合运用和AI技术的研究,LVEF测量标准化和规范化有望进一步改进与加强。Abstract: Left ventricular ejection fraction (LVEF) is a core parameter in the diagnosis, treatment, and management of heart failure. Its measurement accuracy plays a critical role in both basic research and clinical practice. Echocardiography is the preferred tool for non-invasive assessment of LVEF. However, in real-world applications, various factors——including technical limitations, operator experience, and clinical context——can lead to measurement errors, some of which may be substantial. These errors can result in misdiagnosis, inappropriate treatment decisions, and incorrect conclusions. This review analyzes the sources of LVEF measurement errors, discusses quality control strategies, and explores future perspectives. With the advancement of multimodal imaging integration and artificial intelligence technologies, the standardization and normalization of LVEF measurement are expected to improve further.
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Key words:
- ejection fraction /
- left ventricular /
- echocardiography
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[1] Solomon SD, McMurray JJV, Vaduganathan M, et al. Finerenone in Heart Failure with Mildly Reduced or Preserved Ejection Fraction[J]. N Engl J Med, 2024, 391(16): 1475-1485. doi: 10.1056/NEJMoa2407107
[2] Kosiborod MN, Petrie MC, Borlaug BA, et al. Semaglutide in Patients with Obesity-Related Heart Failure and Type 2 Diabetes[J]. N Engl J Med, 2024, 390(15): 1394-1407. doi: 10.1056/NEJMoa2313917
[3] Packer M, Zile MR, Kramer CM, et al. Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity[J]. N Engl J Med, 2025.392(5): 427-437. doi: 10.1056/NEJMoa2410027
[4] Hoeper MM, Oerke B, Wissmüller M, et al. Tadalafil for Treatment of Combined Postcapillary and Precapillary Pulmonary Hypertension in Patients With Heart Failure and Preserved Ejection Fraction: A Randomized Controlled Phase 3 Study[J]. Circulation, 2024, 150(8): 600-610. doi: 10.1161/CIRCULATIONAHA.124.069340
[5] Veltmann C, Duncker D, Doering M, et al. Therapy duration and improvement of ventricular function in de novo heart failure: the Heart Failure Optimization study[J]. Eur Heart J, 2024, 45(30): 2771-2781. doi: 10.1093/eurheartj/ehae334
[6] Clephas PRD, Zwartkruis VW, Malgie J, et al. Pulmonary artery pressure monitoring in chronic heart failure: effects across clinically relevant subgroups in the MONITOR-HF trial[J]. Eur Heart J, 2024, 45(32): 2954-2964. http://www.ncbi.nlm.nih.gov/pubmed/38733175
[7] Anker SD, Friede T, von Bardeleben RS, et al. Transcatheter Valve Repair in Heart Failure with Moderate to Severe Mitral Regurgitation[J]. N Engl J Med, 2024, 391(19): 1799-1809. doi: 10.1056/NEJMoa2314328
[8] Schmitto JD, Shaw S, Garbade J, et al. Fully magnetically centrifugal left ventricular assist device and long-term outcomes: the ELEVATE registry[J]. Eur Heart J, 2024, 45(8): 613-625. doi: 10.1093/eurheartj/ehad658
[9] Mehra MR, Netuka I, Uriel N, et al. Aspirin and Hemocompatibility Events With a Left Ventricular Assist Device in Advanced Heart Failure: The ARIES-HM3 Randomized Clinical Trial[J]. JAMA, 2023, 330(22): 2171-2181. doi: 10.1001/jama.2023.23204
[10] van der Meer P, van Essen BJ, Viljoen C, et al. Bromocriptine treatment and outcomes in peripartum cardiomyopathy: the EORP PPCM registry[J]. Eur Heart J, 2025, 46(11): 1017-1027. doi: 10.1093/eurheartj/ehae559
[11] Lang RM, Badano LP, Mor-Avi V, et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging[J]. J Am Soc Echocardiogr, 2015, 28(1): 1-39. e14. doi: 10.1016/j.echo.2014.10.003
[12] Mitchell CC, Frye C, Jankowski M, et al. A Practical Approach to Echocardiographic Imaging in Patients With Hypertrophic Cardiomyopathy[J]. J Am Soc Echocardiogr, 2023, 36(9): 913-932. doi: 10.1016/j.echo.2023.04.020
[13] Cheng TO. Professor Xin-fang Wang from China is the Father of Modern Echocardiography[J]. Int J Cardiol, 2012, 154(2): 225-231. doi: 10.1016/j.ijcard.2011.12.021
[14] Feigenbaum H. Echocardiographic examination of the left ventricle[J]. Circulation, 1975, 51(1): 1-7. doi: 10.1161/01.CIR.51.1.1
[15] Pombo JF, Troy BL, Russell RO. Left Ventricular Volumes and Ejection Fraction by Echocardiography[J]. Circulation, 1971, 43(4): 480-490. doi: 10.1161/01.CIR.43.4.480
[16] Teichholz LE, Kreulen T, Herman MV, et al. Problems in echocardiographic volume determinations: echocardiographic-angiographic correlations in the presence of absence of asynergy[J]. Am J Cardiol, 1976, 37(1): 7-11. doi: 10.1016/0002-9149(76)90491-4
[17] Schiller NB, Acquatella H, Ports TA, et al. Left ventricular volume from paired biplane two-dimensional echocardiography[J]. Circulation, 1979, 60(3): 547-555. doi: 10.1161/01.CIR.60.3.547
[18] McMurray JJ, Adamopoulos S, Anker SD, et al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association(HFA)of the ESC[J]. Eur Heart J, 2012, 33(14): 1787-1847. doi: 10.1093/eurheartj/ehs104
[19] Akil S, Castaings J, Thind P, et al. Impact of experience on visual and Simpson's biplane echocardiographic assessment of left ventricular ejection fraction[J]. Clin Physiol Funct Imaging, 2025, 45(1): e12918. doi: 10.1111/cpf.12918
[20] Franchi F, Cameli M, Taccone FS, et al. Assessment of left ventricular ejection fraction in critically ill patients at the time of speckle tracking echocardiography: intensivists in training for echocardiography versus experienced operators[J]. Minerva Anestesiol, 2018, 84(11): 1270-1278.
[21] Mor-Avi V, Jenkins C, Kühl HP, et al. Real-time 3-dimensional echocardiographic quantification of left ventricular volumes: multicenter study for validation with magnetic resonance imaging and investigation of sources of error[J]. JACC Cardiovasc Imaging, 2008, 1(4): 413-423. doi: 10.1016/j.jcmg.2008.02.009
[22] Thavendiranathan P, Grant AD, Negishi T, et al. Reproducibility of echocardiographic techniques for sequential assessment of left ventricular ejection fraction and volumes: application to patients undergoing cancer chemotherapy[J]. J Am Coll Cardiol, 2013, 61(1): 77-84. doi: 10.1016/j.jacc.2012.09.035
[23] Christersson M, Gustafsson S, Lampa E, et al. Usefulness of Heart Failure Categories Based on Left Ventricular Ejection Fraction[J]. J Am Heart Assoc, 2024, 13(8): e032257. doi: 10.1161/JAHA.123.032257
[24] Asch FM, Poilvert N, Abraham T, et al. Automated Echocardiographic Quantification of Left Ventricular Ejection Fraction Without Volume Measurements Using a Machine Learning Algorithm Mimicking a Human Expert[J]. Circ Cardiovasc Imaging, 2019, 12(9): e009303. doi: 10.1161/CIRCIMAGING.119.009303
[25] Ouyang D, He B, Ghorbani A, et al. Video-based AI for beat-to-beat assessment of cardiac function[J]. Nature, 2020, 580(7802): 252-256. doi: 10.1038/s41586-020-2145-8
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