Characteristics of coronary artery lesions in patients with coronary artery disease and rheumatoid arthritis
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摘要: 目的:探讨冠心病伴类风湿关节炎(RA)患者的冠状动脉(冠脉)病变特点。方法:连续纳入32例临床诊断RA且冠脉造影确诊为冠心病的患者,同时选取40例无RA的冠心病患者作为对照组,研究两组年龄、性别、血脂、白细胞总数、冠脉病变支数、冠脉病变性质、冠脉狭窄程度及支架植入个数等。结果:两组患者年龄、性别、血总胆固醇、低密度脂蛋白、冠脉病变支数及支架植入个数均差异无统计学意义;RA组冠脉病变性质及冠脉狭窄程度则更严重(P<0.05),白细胞总数、中性粒细胞百分比及高密度脂蛋白较对照组均显著升高(均P<0.05),三酰甘油较对照组则显著降低(P<0.05)。结论:RA可能增加冠脉病变严重程度。Abstract: Objective:To explore the characteristics of coronary artery lesions in the patients with coronary artery disease and rheumatoid arthritis(RA). Method:Thirty-two cases with RA and coronary artery disease diagnosed by coronary angiogram were opted and 40 cases of non-RA and coronary artery disease as control group.We analysed 2 groups in age,sex,blood lipid,blood cell counting,coronary lesion counting,nature of coronary artery lesion,degree of coronary artery stenosis and number of stents implanted with SPSS software. Result:There were no statistical significance between 2 groups in age,sex,total cholesterol,LDL,coronary lesion counting and number of stents implantation.Coronary artery lesion and the coronary artery stenosis in RA group were more serious than control group(P<0.05).And white blood cell counting,neutrophil percentage and HDL in RA group were higher than control group(P<0.05),while triglycerides in RA group was lower than that in control group(P<0.05). Conclusion:RA may increase severity of coronary artery lesions.
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[1] 曾学军.应明确RA诊断中的基本概念[J].中华全科医师杂志,2005,4(3):133-135.
[2] SYMMONS D P,GABRIEL S E.Epidemiology ofCVD in rheumatic disease,with a focus on RA andSLE[J].Nat Rev Rheumatol,2011,7:399-408.
[3] SIHVONEN S,KORPELA M,LAIPPALA P,et al.Death rates and causes of death in patients with rheumatoid arthritis:apopulation-based study[J].ScandJ Rheumatol,2004,33:221-227.
[4] MARADIT-KREMERS H,NICOLA P J,CROWSONC S,et al.Cardiovascular death in rheumatoid arthritis:apopulation-based study[J].Arthritis Rheum,2005,52:722-732.
[5] KIMURA T,WATANABE S.Nonatherosclerotic coronary artery disease[J].Nippon Rinsho,2007,2:228-233.
[6] DEL RINCON I D,WILLIAMS K,STERN M P,etal.High incidence of cardiovascular events in a rheumatoid arthritis cohort not explained by traditionalcardiac risk factors[J].Arthritis Rheum,2001,44:2737-2745.
[7] SOLOMOM D H,GOODSON N J,KATZ J N,etal.Patterns of cardiovascular risk in rheumatoid arthritis[J].Ann Rheum Dis,2006,65:1608-1612.
[8] FISCHER L M,SCHLIENGER R G,MATTER C,et al.Effect of rheumatoid arthritis or systemic lupuserythematosus on the risk of first-time acute myocardial infarction[J].Am J Cardiol,2004,93:198-200.
[9] AUBRY M C,MARADIT-KREMERS H,REINALDA M S,et al.Differences in atherosclerotic coronaryheart disease between subjects with and without rheumatoid arthritis[J].J Rheumatol,2007,34:937-942.
[10] WARRINGTON K J,KENT P D,FRYE R L,et al.Rheumatoid arthritis is an independent risk factor formulti-vessel coronary artery disease:a case controlstudy[J].Arthritis Res Ther,2005,7:R984-991.
[11] YALAMANCHILI K,ARONOW W S,KILARU R,et al.Coronary artery disease is more severe in olderpersons with rheumatoid arthritis than in older persons without rheumatoid arthritis[J].Cardiol Rev,2006,14:55-56.
[12] DESAI S P,JANUZZI J L,PANDE A N,et al.Comparison of symptoms,treatment,and outcomes of coronary artery disease among rheumatoid arthritis andmatched subjects undergoing percutaneous coronary intervention[J].Semin Arthritis Rheum,2010,40:215-221.
[13] GZIUT A I,SEWERYNIAK P.Dissection of coronary artery during primary PCI in a patient with rheumatoid arthritis[J].Kardiol Pol,2007,65:1389-1390.
[14] STEINER G,UROWITZ M B.Lipid profiles in patients with rheumatoid arthritis:mechanisms and theimpact of treatment[J].Semin Arthritis Rheum,2009,38:372-381.
[15] 彭道泉.HDL治疗的新靶点[J].中国心血管杂志,2008,13(2):81-85.
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