不稳定型心绞痛患者细胞黏附分子水平及颈动脉斑块性质的研究

宗春绕; 蒋树中

doi:10.13201/j.issn.1001-1439.2012.07.011

不稳定型心绞痛患者细胞黏附分子水平及颈动脉斑块性质的研究

宗春绕^1, ,,
蒋树中²

- 1. 徐州矿务集团第一医院内科(221131);
- 2. 徐州中心医院心内科

详细信息

通讯作者: 宗春绕,E-mail:zongchunrao@163.com

中图分类号: R541.4

收稿日期: 2012-03-12

修回日期: 2012-04-21

Relationship between adhesion molecules,carotid atherosclerotic plaque and unstable angina pectoris

ZONG Chunrao^1, ,,
JIANG Shuzhong²

- 1. Internal Medicine Department, the First Hospital of Xuzhou Mining Affairs Group, Xuzhou, Jiangsu, 221131, China;
- 2. the Centre Hospital of Xuzhou

More Information

Corresponding author: ZONG Chunrao, E-mail: zongchunrao@163.com

Received Date: 12 March 2012

Revised Date: 21 April 2012

摘要

摘要: 目的:探讨血中黏附分子水平及颈动脉斑块性质与不稳定型心绞痛 (UAP) 的关系。方法:对50例稳定型心绞痛 (SAP) 和50例UAP患者, 分别应用颈动脉超声检查颈动脉斑块的性质, 酶联免疫吸附法 (ELISA) 检测血清中的可溶性血管细胞黏附因子-1 (sVCAM-1) 和可溶性细胞间黏附因子-1 (sICAM-1) 水平。结果:UAP组颈动脉斑块以脂质斑块为主 (52.1%), SAP组主要为纤维性斑块 (50.9%)。UAP组患者血清中sVCAM-1和sICAM-1均明显增高, 与SAP组比较差异有统计学意义 (P<0.05)。结论:UAP与颈动脉硬化不稳定斑块及可溶性黏附分子水平的升高密切相关。
- 心绞痛 /
- 可溶性黏附分子 /
- 颈动脉粥样硬化斑块
Abstract: Objective:To explore the relationship between sVCAM-1 (full name) , carotid atherosclerotic plaque and unstable angina pectoris (UAP) . Method:Fifty patients with stable angina pectoris (SAP) and fifty patients with UAP were collected in the study.Ultrasonographic features of carotid plaque were detected in all patients.sVCAM-1 and sICAM-1 were measured by ELISA. Result:Fatty plaques were the main types of plaques seen in UAP (52.1%) , while fibrous plaques were prevalent in SAP (50.9%) .Concentration of sVCAM-1 and sICAM-1 were significantly higher in UAP patients than those in SAP patients (P<0.05) . Conclusion:Levels of sVCAM-1 and sICAM-1 and characteristics of carotid atherosclerotic plaque may be important markers in predicting unstable plaques prone to rupture.
- angina pectoris /
- soluble adhesion molecule /
- carotid atherosclerotic plaque

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参考文献(10)

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