Relationship of high-sensitive C-reactive protein,IL-6 and atrial fibrillation combining with thrombosis
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摘要: 目的:探讨心房颤动（房颤）患者血浆高敏C-反应蛋白（hs-CRP）、白细胞介素6（IL-6）与左房内血栓形成的关系。方法:根据心脏超声检查结果将148例房颤患者分为血栓组（56例）和非血栓组（92例）,分别测定两组血浆hs-CRP和IL-6浓度,同时测定左房内径及左室射血分数（LVEF）,分析hs-CRP、IL-6与血栓形成的关系。结果:血栓组血浆hs-CRP与IL-6浓度均明显高于非血栓组[（4.38±0.56）g/L∶（1.12±0.27）g/L,（156.6±29.4）ng/L∶（114.5±20.7）ng/L;均P<0.05];Logistic回归发现,高hs-CRP（OR=2.631）、高IL-6（OR=2.965）及左房内径扩大（OR=4.337）是血栓形成的独立危险因素（均P<0.05）。结论:hs-CRP及IL-6升高、左房扩大是房颤患者左房血栓形成的独立危险因素,炎症反应在房颤心房血栓形成过程中可能起重要作用。Abstract: Objective:To investigate the alteration of plasma high-sensitive C-reactive protein（hs-CRP） and interleukin-6（IL-6） in patients with atrial fibrillation combining thrombosis.Method:Patients with atrial fibrillation were divided into thrombus group（n=56） and non-thrombus group（n=92） according to echocardiography results.The plasma hs-CRP and IL-6 concentrations and LVEF values as well as left atrium diameter were measured.Logistic multi-factors regression analysis was performed.Result:Plasma hs-CRP and IL-6 concentrations in thrombus group were significantly higher than those in non-thrombus group [（4.38±0.56）g/L:（1.12±0.27）g/L,（156.6±29.4）ng/L:（114.5±20.7）ng/L;both P<0.05].Logistic multi-factors regression analysis showed that high plasma concentrations of hs-CRP（OR=2.631）,IL-6（OR=2.965） and enlarged left atrium diameter（OR=4.337） were main independent risk factors of patients with atrial fibrillation combining thrombosis（all P<0.05）.Conclusion:hs-CRP and IL-6 were independent risk factors of patients with atrial fibrillation combining thrombosis.Inflammatory reaction may play an important role in the formation of thrombosis in patients with atrial fibrillation.
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Key words:
- atrial fibrillation /
- high-sensitive C-reactive protein /
- interleukin-6 /
- thrombosis
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