促红细胞生成素对急性心肌梗死心脏保护性作用的研究进展

刘园园, 崔丽, 付乃宽. 促红细胞生成素对急性心肌梗死心脏保护性作用的研究进展[J]. 临床心血管病杂志, 2013, 29(3): 168-170. doi: 10.13201/j.issn.1001-1439.2013.03.011
引用本文: 刘园园, 崔丽, 付乃宽. 促红细胞生成素对急性心肌梗死心脏保护性作用的研究进展[J]. 临床心血管病杂志, 2013, 29(3): 168-170. doi: 10.13201/j.issn.1001-1439.2013.03.011
LIU Yuanyuan, CUI Li, FU Naikuan. Protective effects of erythropoietin against myocardial infarction[J]. J Clin Cardiol, 2013, 29(3): 168-170. doi: 10.13201/j.issn.1001-1439.2013.03.011
Citation: LIU Yuanyuan, CUI Li, FU Naikuan. Protective effects of erythropoietin against myocardial infarction[J]. J Clin Cardiol, 2013, 29(3): 168-170. doi: 10.13201/j.issn.1001-1439.2013.03.011

促红细胞生成素对急性心肌梗死心脏保护性作用的研究进展

详细信息
    通讯作者: 刘园园,E-mail:liuyuanyuan1977@163.com
  • 中图分类号: R542.2

Protective effects of erythropoietin against myocardial infarction

More Information
  • 促红细胞生成素(EPO)是细胞因子超家族成员之一,对发生疾病的心脏发挥重要的保护作用。大量动物实验证实,EPO可以发挥抗细胞凋亡、抗氧化、抗炎及促进血管再生等作用,减小梗死面积、减轻左室重构,并改善心功能。
  • 加载中
  • [1]

    SLOMIANY M G,ROSENZWEIG S A.Hypoxia-in-ducible factor-1-dependent and-independent regulation of insulin-like growth factor-1-stimulated vascular en-dothelial growth factor secretion[J].J Pharmacol Exp Ther,2006,318:666-675.

    [2]

    NISHIYA D, OMURA T, SHIMADA K, et al. Effects of erythropoietin on cardiac remodeling after myocardial infarction[J]. J Pharmacol Sci,2006,101:31-39.

    [3]

    KLOPSCH C,FURLANI D,GABEL R,et al.Intra-cardiac injection of erythropoietin induces stem cell re-cruitment and improves cardiac functions in a rat myo-cardial infarction model[J].J Cell Mol Med,2009,13:664-679.

    [4]

    MITSUMA W,ITO M,KODAMA M,et al.Car-dioprotective effects of recombinant human erythro-poietin in rats with experimental autoimmune myocar-ditis[J].Biochem Biophys Res Commun,2006,344:987-994.

    [5]

    VAN DER MEER P,LIPSIC E.Erythropoietin:re-pair of the failing heart[J].J Am Cell Cardiol,2006,48:185-186.

    [6]

    WESTENBRINK B D.Erythropoietin improves cardi-ac function through endothelial progenitor cell and vascular endothelial growth factor mediated neovascu-larization[J].Eur Heart J,2007,28:2018-2027.

    [7]

    TOMA C. Positive effect of darbepoetin on peri-infarction remodeling in a porcine model of myocardial ischemia-reperfusion[J]. J Mol Coll Cardiol,2007,43:130-136.

    [8]

    HIRATA A,MINAMINO T,ASANUMA H,et al.Erythropoietin enhances neovascularization of ischemic myocardium and improves left ventricular dysfunction after myocardial infarction in dogs[J].J Am Coll Car-diol,2006,48:176-184.

    [9]

    MOON C, KRAWCZYK M, LAKATTA E G, et al. Therapeutic effectiveness of a single vs multiple doses of erythropoietin after experimental myocardial infarction in rats[J]. Cardiovasc Drugs Ther,2006,20:245-251.

    [10]

    GAO E,BOUCHER M,CHUPRUN J K,et al.Darbepoetin alfa,a long-acting erythropoietin analog,offers novel and delayed cardioprotection for the ische-mic heart[J].Am J Physiol Heart Circ Physiol,2007,293:60-68.

    [11]

    LIPSIC E,VAN DER MEER P,VOORS A A,et al.A single bolus of a long-acting erythropoietin analogue darbepoetin alfa in patients with acute myocardial in-farction:a randomized feasibility[J].Cardiovasc Drugs Ther,2006,20:135-141.

    [12]

    NAKAMURA R,TAKAHASHI A,YAMADA T,et al.Erythropoietin in patients with acute coronary syn-drome and its cardioprotective action after percutaneous coronary intervention[J].Circ J,2009,73:1920-1926.

    [13]

    FERRARIO M,MASSA M,ROSTI V,et al.Early haemoglobin-independent increase of plasma erythro-poietin levels in patients with acute myocardial infarc-tion[J].Eur Heart J,2007,28:1805-1813.

    [14]

    BELONJE A M, WESTENBRINK B D, VOORS A A, et al. Erythropoietin levels in heart failure after an acute myocardial infarction: Determinants, prognostic value, and the effects of captopril versus losartan[J]. Am Heart J,2009,157:91-96.

    [15]

    OZAWA T.Single-dose intravenous administration of recombinant human erythropoietin is a promising treatment for patients with acute myocardial infarc-tion-randomized controlled pilot trial of EPO/AMI-1 study[J].Circ J,2010,74:1415-1423.

  • 加载中
计量
  • 文章访问数:  18
  • PDF下载数:  15
  • 施引文献:  0
出版历程
收稿日期:  2012-06-11

目录