HDL-C对经皮冠状动脉介入治疗ST段抬高性心肌梗死预后的影响

姜娜; 丁世芳; 张再伟; 卢青; 蒋桔泉; 龚志刚; 王华; 彭毅; 侯云; 王慧洁; 付文波; 陈志楠

doi:10.13201/j.issn.1001-1439.2013.05.014

HDL-C对经皮冠状动脉介入治疗ST段抬高性心肌梗死预后的影响

- 广州军区武汉总医院心内科(武汉. 430070)
基金项目:
湖北省自然科学基金重点项目（No：2010CDA036）

详细信息

通讯作者: 丁世芳,E-mail:DSFMD@yahoo.com.cn

中图分类号: R542.2

收稿日期: 2013-01-10

Prognostic implication of HDL-C in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention

- Department of Cardiology, General Hospital of Guangzhou Military Command, Wuhan, 430070, China

More Information

Corresponding author: DING Shifang, E-mail: DSFMD@yahoo.com.cn

Received Date: 10 January 2013

摘要

摘要: 目的：探讨HDL-C水平对接受急诊经皮冠状动脉介入治疗（PCI）的急性ST段抬高性心肌梗死（STEMI）患者住院期间预后的影响。方法：回顾性分析352例接受急诊PCI的STEMI患者的临床资料，根据入院空腹HDL-C水平分成HDL-C降低组（HDL-C<1.04mmol/L，125例）和HDL-C正常组（HDL-C≥1.04mmol/L，227例）。比较2组住院期间病死率和联合心脏事件的发生情况。结果：与HDL-C正常组比较，HDL-C降低组的Killip分级≥Ⅱ级比例和既往糖尿病史比例增加，TC、LDL-C水平下降，TG水平增加（均P<0.05）。HDL-C降低组的住院期间病死率较HDL-C正常组增加（P<0.01），但2组联合心脏事件发生率差异无统计学意义。多因素Logistic回归分析显示，HDL-C是患者住院期间病死率的独立危险因素（P<0.01）。结论：对于接受急诊PCI的STEMI患者，HDL-C水平降低与住院期间病死率增加有关。HDL-C是接受急诊PCI的STEMI患者住院期间病死率的独立危险因素。
- 心肌梗死 /
- 高密度脂蛋白胆固醇 /
- 血管成形术 /
- 经腔 /
- 经冠状动脉 /
- 预后
Abstract: Objective: To explore the prognostic value of HDL-C in patients with ST-elevation myocardial infarction(STEMI) treated with primary percutaneous coronary intervention(PCI). Method: A total of 352 patients with STEMI treated with primary PCI were enrolled and divided into low HDL-C group(HDL-C<1.04 mmol/L) and normal HDL-C group(HDL-C ≥ 1.04 mmol/L).End points were death and composite of cardiac events during in-hospital.The relationship between HDL-C and the above end points was testified. Result: Compared with patients in normal HDL-C group, patients in low HDL-C group had higher incidence of diabetes and Killip class ≥ Ⅱ, lower TC and LDL-C, higher TG and in-hospital mortality(all P<0.05).In multi-variable analysis, lowHDL-C was associated with the risk of death after adjusting for other independent predictors of outcomes(P<0.01). Conclusion: Significantly higher in-hospital mortality is associated with low HDL-C.In patients with STEMI undergoing primary PCI, a baseline HDL-C is an important prognostic indicator of in-hospital mortality.
- myocardial infarction /
- high-density lipoprotein cholesterol /
- angioplasty /
- transluminal /
- percutaneous coronary /
- prognosis

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