Abstract: Objective: To study the effects of rosuvastatin on high-sensitivity C-reactive protein (hs-CRP) and insulin resistance (IR) in patients with hypertension and hyperlipidemia.Method: All 100patients with hypertension and hyperlipidemia were randomly divided into treatment group (n=50) and control group (n=50).Both groups were treated with antihypertensive treatment, and treatment group was additionally treated with rosuvastatin (10mg/d) for 8weeks.Other 50normal subjects whose age, gender were matched were selected as healthy group.The changes of blood pressure, blood lipids, FPG, hs-CRP and insulin resistance index (HOMA-IR) in all were measured before and after treatment.Result: Levels of serum hs-CRP, HOMA-IR, blood pressure, total cholesterol (TC), triglyeride (TG) and low density lipoprotein-cholesterol (LDL-C) were significantly higher in treatment group and control group than those in healthy group (all P<0.05), whereas high density lipoproteincholesterol (HDL-C) was lower (P<0.05).Pearson linear correlation analysis showed that hs-CRP was positively correlated with HOMA-IR (r=0.527, P<0.05).Levels of serum hs-CRP, HOMA-IR, blood pressure, TC, TG and LDL-C decreased significantly in treatment group after 8weeks of treatment (all P<0.05), Levels of HDL-C increased significangtly (P <0.05), BMI had no significant difference.While blood pressure was decreased (P<0.01) and other indexes were not found significant differenc in control group.The comparison of TC, LDL-C, HDL-C, HOMA-IR and hs-CRP between two groups were significantly different after the treatment (all P<0.05).Conclusion: The treatment of rosuvastatin in patients with hypertension and hyperlipidemia can not only regulate the levels of blood lipids, but also decrease the serum hs-CRP and HOMA-IR, acting as anti-inflammatory and improving IR.