血流储备分数与血管内超声指导冠状动脉临界病变介入治疗临床预后的研究

陈弢; 郜俊清; 刘宗军; 汪志华; 孙剑光; 于宏梅; 赵德强

doi:10.13201/j.issn.1001-1439.2014.07.012

血流储备分数与血管内超声指导冠状动脉临界病变介入治疗临床预后的研究

- 上海市普陀区中心医院心内科(上海, 200062)
基金项目:
上海市科学技术委员会资助项目 (No:124119b1600)

国家自然科学基金项目 (No:81303145)

2011年普陀区卫生系统自主创新科研资助重点项目 (No:3)

详细信息

通讯作者: 于宏梅,E-mail:95885209@qq.com; 赵德强

中图分类号: R541.4

收稿日期: 2013-10-20

Study on clinical outcomes of fractional flow reserve and intravascular ultrasound guidance with critical coronary interventional treatment

- Department of Cardiology, Center Hospital in Putuo District, Shanghai, 200062, China

More Information

Corresponding authors: YU Hongmei ; ZHAO Deqiang

Received Date: 20 October 2013

摘要

摘要: 目的:运用血管内超声 (IVUS) 与血流储备分数 (FFR) 指导介入治疗, 以观察患者远期临床预后。方法:选择冠状动脉 (冠脉) 造影结果为临界病变 (狭窄40%~70%) 的患者, 并接受FFR检查或IVUS, 并以此作为是否冠脉介入治疗 (PCI) 依据。观察两组患者植入支架数目, 随访期间心脏不良事件, 心绞痛发生次数及加拿大心绞痛分级。结果:经过IVUS指导有32例接受冠脉支架植入治疗, 经过FFR指导有14例接受冠脉支架植入治疗。两组患者1年后心脏主要不良事件未见明显差异, 心绞痛发生次数、发生例数与心绞痛分级两组没有统计学差异。结论:冠脉临界病变, 无论是采用FFR还是IVUS指导冠脉介入治疗, 两组患者临床预后相似, 但是IVUS组可能会植入更多的冠脉支架。
- 血流储备分数 /
- 血管内超声 /
- 临界病变
Abstract: Objective: To observe the long-term clinical outcome from the intravascular ultrasound (IVUS) or fraction and flow reserve (FFR) in interventional treatment.Method: The patients were collected with critical lesions (stenosis 40%~70%) from coronary angiography, and underwent FFR or IVUS, as a basis for whether PCI or not.Comparison of two groups of patients, implanted stent number, follow-up adverse cardiac events, times of angina pectoris of angina pectoris grade were observed.Result: After IVUS guide, 32 people received coronary stent implantation, and after FFR guide, 14 people received coronary stent implantation.Follow-up for 1year, major adverse cardiac events, the number of angina pectoris, the occurrence of angina in patients with angina pectoris of angina pectoris grade were not statistically different between two groups.Conclusion: Either FFR or IVUS guided PCI, clinical outcomes are similar.However, the IVUS group may cause coronary stent implantation more.
- fractional flow reserve /
- intravascular ultrasound /
- critical disease

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参考文献(7)

[1]	RZECZUCH K, SZAJN G, JANKOWSKA E, et al.Borderline coronary lesions may lead to serious coronary events-long-term outcome in 65conservatively treated patients[J].Kardiol Pol, 2005, 63:50-56.
[2]	TONINO P A L, FEARON W F, BRUYNE B D, et al.Angiographic versus functional severity of coronary artery stenoses in the FAME Study[J].JACC, 2010, 55:217-221.
[3]	SAUCEDO J F, LANSJY A J, ITO S, et al.A practical approach to quantitative coronary angiography.In:Beyar R, Keren G, Leon M B, et al, editors.Frontiers in interventional cardiology[M].London:Martin Dunitz Publishers;1997:281-296.
[4]	DE SCHEERDER I, DE MAN F, HERREGODS M C, et al.Intravascular ultrasound versus angiography for measurement of luminal diameters in normal and diseased coronary arteries[J].Am Heart J, 1994, 127:243-251.
[5]	NAM C W, YOOM H J, YUN K, et al.Outcomes of percutaneous coronary intervention in intermediate coronary artery disease[J].JACC, 2010, 3:812-817.
[6]	PIJLS N H, VAN SON J A, KIRKEEIDE R L, et al.Experimental basis of determining maximum coronary, myocardial, and collateral blood flow by pressure measurements for assessing functional stenosis severity before and after percutaneous transluminal coronary angioplasty[J].Circulation, 1993, 87:1354-1367.
[7]	TONIN O, FEARO N, BRUYN E, et al.Angiographic versus functional severity of coronary artery stenoses in the FAME study[J].JACC, 2009, 55:2816-2821.