最大颈动脉内膜中层厚度及颈动脉斑块对冠心病预测的相关性研究

蒋鹏; 姜巧珍; 任鸿坤; 高迎春; 窦丽; 任志亮

doi:10.13201/j.issn.1001-1439.2015.05.017

最大颈动脉内膜中层厚度及颈动脉斑块对冠心病预测的相关性研究

- 内蒙古自治区人民医院心内科(呼和浩特, 010020)

详细信息

作者简介:
高迎春,E-mail:gaodaifu001@yahoo.com.cn

中图分类号: R541.4

收稿日期: 2014-06-28

Maximum carotid intima-media thickness and carotid plaques for predicting coronary heart disease

- Department of Cardiology, People's Hospital of Inner Mongolia Autonomous Region, Huhhot, 010017, China

Received Date: 28 June 2014

摘要

摘要: 目的:探讨最大颈动脉内膜中层厚度(cIMT)及颈动脉斑块对冠心病(coronary heart disease,CHD)的诊断预测作用。方法:将无CHD史的214例患者经冠状动脉(冠脉)CT或冠脉造影证实冠脉狭窄≥50%分为CHD组82例和无CHD组132例。记录一般情况、入院血压及血脂数据,测量最大cIMT以及记录颈动脉斑块位置。结果:CHD组中最大cIMT明显大于无CHD组,差异有统计学意义[(1.09±0.20)∶(0.99±0.20),P<0.01]。CHD组颈总动脉斑块和颈动脉窦斑块发生概率与无CHD组相比有显著增加(P<0.01)。而两组的颈内动脉斑块发生概率则无显著差异。将入组的CHD危险因素、最大cIMT及颈动脉斑块进行logistic回归后退法分析,发现高血压(OR=3.052,95%CI1.671~5.782,P<0.01)和颈总动脉斑块(OR=2.757,95%CI1.283~5.924,P<0.01)、颈动脉窦斑块(OR=2.635,95%CI1.425~4.873,P<0.01)与CHD的发生明显相关,是CHD的强预测因素。结论:颈总动脉斑块及颈动脉窦斑块是CHD的强预测因素,可作为临床辅助预测CHD的简便、无创、有效的诊断预测指标。
- 颈动脉内中膜厚度 /
- 颈动脉斑块 /
- 冠心病
Abstract: Objective:The purpose of this study was to evaluate the value of maximum carotid intima-media thickness(cIMT) and carotid plaques for predicting coronary artery disease(CHD).Method:Two hundred and fourteen patients with no history of coronary heart disease underwent computed tomography angiography or coronary angiography.And then divided into CHD group(n=82) and non-CHD group(n=132) which due to coronary artery stenosis ≥ 50%,measured blood pressure and blood fat,and measured maximum cIMT and recorded the position of carotid plaques.Result:Maximum cIMT was significantly higher in CHD group than which in nonCHD group(1.09±0.20 vs 0.99±0.20,P<0.01).The incidence of plaque in common carotid artery(CCA) and carotid blub(CB) in CHD group were significantly increased than non-CHD group(P<0.01).But there was no significant difference in internal carotid artery(ICA).Multiple logistic regression backward analysis reveals that hypertension(OR=3.052,95%CI 1.671~5.782,P<0.01) and CCA plaque(OR=2.757,95%CI 1.283~5.924,P<0.01)、CB plaque(OR=2.635,95% CI 1.425~4.873,P<0.01) were associated with CHD,which were stronger predictor of CHD.Conclusion:CCA plaque and CB plaque were stronger predictor of CHD which could be used as a simple,noninvasive and useful marker for prediction of CHD.
- carotid intima-media thickness /
- carotid artery plaque /
- coronary artery disease

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