急性心肌梗死患者血清白三烯B<sub>4</sub>和基质金属蛋白酶-9表达的变化及其意义

徐晨凯; 刘小伟; 唐礼江; 林峰; 陈建明; 金红锋; 曾广忠; 米亚飞; 杨海华; 陈晓锋; 王琳; 许莎莎; 朱敏

doi:10.13201/j.issn.1001-1439.2015.05.018

急性心肌梗死患者血清白三烯B₄和基质金属蛋白酶-9表达的变化及其意义

- 1 温州医科大学附属第一医院(浙江温州, 325000);
- 2 浙江医院心内科;
- 3 浙江省台州医院心内科;
- 4 浙江省台州医院公共实验室
基金项目:
浙江省医药卫生科技计划项目(No:2011ZDA028)

详细信息

作者简介:
唐礼江,E-mail:taizhoutang@hotmail.com

中图分类号: R542.2

收稿日期: 2014-07-30

Dynamic observation on leukotriene B₄ and matrix metalloproteinase-9 levels in patients with acute myocardial infarction

- 1 The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China;
- 2 Department of Cardiology, Zhejiang Hospital;
- 3 Department of Cardiology, Taizhou Hospital;
- 4 Department of public Lab, Taizhou Hospital

Received Date: 30 July 2014

摘要

摘要: 目的:探讨急性ST段抬高型心肌梗死(STEMI)患者血清白三烯B₄(LTB₄)和基质金属蛋白酶-9(MMP-9)表达的动态变化及其临床意义。方法:采用酶联免疫吸附法(ELISA)测定40例STEMI患者入院48h及出院后第3个月、6个月血清中LTB₄及MMP-9的表达;全自动生化分析仪测定脂蛋白(a)。结果:与入院水平相比,STEMI患者血清LTB₄的表达水平在出院后第3个月及第6个月呈持续性下降,结果有统计学意义(P<0.05);出院后第3个月MMP-9的表达显著低于入院时水平(P<0.05),而与第6个月相比差异无统计学意义(P>0.05)。在脂蛋白(a)总体较高25%水平与总体较低25%水平的患者血清中MMP-9的差异有统计学意义(P<0.05)。结论:STEMI患者院外3~6个月随访发现其血清中LTB₄和MMP-9的表达呈动态变化,其中LTB₄血清水平呈进行性降低,脂蛋白(a)显著增高人群在发生心肌梗死时其MMP-9水平较高。
- 急性ST段抬高型心肌梗死 /
- 白三烯B₄ /
- 基质金属蛋白酶-9 /
- 脂蛋白(a)
Abstract: Objective:To investigate the changes of Leukotriene B₄(LTB₄) and Matri-x metalloproteinase-9(MMP-9) in patients with acute myocardial infarction(AMI) in a six months follow-up study and to explore its potential clinical significance.Method:LTB₄and MMP-9were measured by enzyme-linked immunosorbent assay in40 AMI patients when patients were enrolled in hospital during 48 hours,three months and six months.Result:LTB₄level was significant lower in blood of AMI patients 6th month than blood of patients 3rd month after leaving the hospital and patients who had been hospitalized within 48hours(P<0.05),MMP-9level was significant higher in blood of patients 48 hours after enrolling the hospital than 3rd month and 6th month after leaving the hospital(P<0.05),withno significant difference between 6th month and 3rd month(P>0.05).The concentration of MMP-9in the top 25 percent of Lp(a) level is significant higher than the last 25percent(P<0.05).Conclusion:The serum level of LTB₄ and MMP-9decline after AMI,What's more the level of LTB₄ proceeded to decline after AMI.Significant high concentration of Lp(a) may effect the level of MMP-9in AMI patients.
- ST-elevated Myocardial Infarction /
- Leukotriene B₄ /
- Matrix Metalloproteinase-9 /
- Lipoprotein(a)

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参考文献(7)

[1]	ZHOU G,GE S,LIU D,et al.Atorvastatin reduces plaque vulnerability in an atherosclerotic rabbit model by altering the 5-lipoxygenase pathway[J].Cardiology, 2010,115:221-228.
[2]	XU S,TANG L,MI Y,et al.Clinical significance of leukotriene b4 and extracellular matrix metalloproteinase inducer in acute coronary syndrome[J].Clin Invest Med,2013,36:E282-E289.
[3]	HLAWATY H,JACOB M P,LOUEDEC L,et al.Leukotriene receptor antagonism and the prevention of extracellular matrix degradation during atherosclerosis and in-stent stenosis[J].Arterioscler Thromb Vasc Biol,2009,29:518-524.
[4]	EMERGING RISK FACTORS COLLABORATION,ERQOU S,KAPTOGE S,PERRY P L,et al.Lipoprotein (a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality[J].JAMA,2009.302:412-423.
[5]	SEIMON T A,NADOLSKI M J,LIAO X,et al.Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress[J].Cell Metab,2010,12:467-482.
[6]	TSIMIKAS S,BRILAKIS E S,MILLER E R,et al.Oxidized phospholipids, Lp (a) lipoprotein, and coronary artery disease[J].N Engl J Med,2005,353:46-57.
[7]	HUANG M,GONG Y,GRONDOLSKY J,et al.Lp (a)/apo (a) modulate MMP-9 activation and neutrophil cytokines in vivo in inflammation to regulate leukocyte recruitment[J].Am J Pathol,2014,184:1503-1517.