非ST段抬高急性冠状动脉综合征患者血浆D-二聚体与GRACE评分的相关研究

夏磊; 杨文; 李斌; 陈思锦

doi:10.13201/j.issn.1001-1439.2015.08.012

非ST段抬高急性冠状动脉综合征患者血浆D-二聚体与GRACE评分的相关研究

- 松滋市人民医院心血管内科(湖北松滋, 434200)

详细信息

通讯作者: 夏磊,E-mail:xialei511@aliyun.com

中图分类号: R541.4

收稿日期: 2014-11-30

修回日期: 2015-01-27

Correlation between the D-dimer and GRACE risk score in patients with non-ST-segment elevation acute coronary syndrome

- Department of Cardiology, The People's Hospital of Songzi, Songzi, Hubei, 434200, China

More Information

Corresponding author: XIA Lei, E-mail: xialei511@aliyun.com

Received Date: 30 November 2014

Revised Date: 27 January 2015

摘要

摘要: 目的：探讨非ST段抬高急性冠状动脉综合征（NSTE-ACS）患者血浆D-二聚体水平与全球急性冠状动脉事件注册（GRACE）评分的关系。方法：入选151例在我院住院的NSTE-ACS患者，其中不稳定性心绞痛（UA）40例，非ST段抬高心肌梗死（NSTEMI）111例。入院后测定血浆D-二聚体浓度，计算GRACE评分并进行危险分层，分析NSTE-ACS患者血浆D-二聚体水平与GRACE评分及危险分层的关系。结果：NSTEMI组D-二聚体含量的平方根及GRACE评分均高于UA组（P<0.05和P<0.01）。将所有NSTE-ACS患者作GRACE危险分层，高危组D-二聚体含量的平方根明显高于中危组及低危组（均P<0.01），中危组与低危组D-二聚体含量的平方根差异无统计学意义（P>0.05）。将所有NSTE-ACS患者按D-二聚体含量<1.0 μg/ml和≥ 1.0 μg/ml分为低D-二聚体组和高D-二聚体组，高D-二聚体组GRACE评分明显高于低D-二聚体组（P<0.01）。NSTE-ACS患者D-二聚体的平方根与GRACE评分呈正相关（r=0.335，P<0.01）。结论：NSTE-ACS患者血浆D-二聚体水平与GRACE评分具有良好的相关性。D-二聚体水平对于NSTE-ACS患者的早期危险分层具有一定的价值。
- 急性冠状动脉综合征 /
- D-二聚体 /
- 全球急性冠状动脉事件注册评分 /
- 危险分层
Abstract: Objective: To explore the relationship between plasma D-dimer level obtained on admission and global registry of acute coronary events (GRACE) risk scores in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS).Method: A total of 151 NSTE-ACS patients admitted in our hospital were chosen, including 40 patients with unstable angina (UA) and 111 patients with non-ST-segment elevation myocardial infarction (NSTEMI). On admission plasma D-dimer was measured in all patients and the GRACE risk score was used for risk stratification. Analyze the relationship between D-dimer level and GRACE risk score as well as risk stratification in patients with NSTE-ACS.Result: The square root of plasma D-dimer of NSTEMI group was higher than UA group (P<0.05), as well as GRACE risk score (P<0.01). According to GRACE risk stratification, the square root of D-dimer of high-risk group was the highest among the three groups (P<0.01). The GRACE risk score in patients of high D-dimer levels was significantly increased compared with patients of low D-dimer levels (P<0.01). The square root of D-dimer in patients with NSTE-ACS had positive correlation with the GRACE risk score (r=0.335, P<0.01).Conclusion: Increased plasma D-dimer level was associated with increased GRACE risk score in NSTE-ACS patients. Measuring D-dimer level is valuable for early risk stratification in patients with NSTE-ACS.
- acute coronary syndrome /
- D-dimer /
- global registry of acute coronary events risk score /
- risk stratification

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