慢性心力衰竭患者血浆NGAL水平变化及与NT-proBNP相关性的研究

陈薇; 胡汉宁; 黎安玲; 刘艳源

doi:10.13201/j.issn.1001-1439.2015.08.016

慢性心力衰竭患者血浆NGAL水平变化及与NT-proBNP相关性的研究

- 武汉大学中南医院检验科(武汉, 430071)
基金项目:
湖北省自然科学基金（No：2012FFB04411）

详细信息

通讯作者: 胡汉宁,E-mail:hhn_2296@sina.com

中图分类号: R541.6

收稿日期: 2014-11-26

修回日期: 2015-01-06

Relationship of neutrophil gelatinase associated lipocalin and N- terminal pro-B-type natriuretic peptide in chronic heart failure

- Department of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China

More Information

Corresponding author: HU Hanning, E-mail: hhn_2296@sina.com

Received Date: 26 November 2014

Revised Date: 06 January 2015

摘要

摘要: 目的：观察97例慢性充血性心力衰竭（CHF）患者血浆中性粒细胞明胶酶相关脂质运载蛋白（NGAL）和N-末端B型脑钠肽前体（NT-proBNP）等指标水平变化，并探讨两者间的相关关系。方法：收集97例CHF患者（CHF组）的临床资料，进行回顾性分析。同期年龄相同体检为健康者50例作为对照组。比较分析CHF组与对照组血浆中NGAL、NT-proBNP，尿素氮（BUN）、肌酐（Cr）、肾小球滤过率（eGFR）以及左心功能指标左心室射血分数（LVEF）。结果：CHF组患者血NGAL、血NT-proBNP、BUN和Cr水平明显高于对照组（均P<0.05），而LVEF、eGFR低于对照组（P<0.05），血NGAL、NT-proBNP在各组中水平依次是NYHA-Ⅳ级>NYHA-Ⅲ级>NYHA-Ⅱ级>NYHA-Ⅰ级，各级间差异均有统计学意义（P<0.05）。CHF组患者血清NGAL与NT-proBNP呈正相关（r=0.79，P<0.05），LVEF与血浆NGAL、NT-proBNP水平呈负相关（r=-0.36，P<0.05；r=-0.39，P<0.05）。结论：CHF组患者血浆NGAL和NT-proBNP水平升高与心力衰竭、肾损伤的发展进程有关。
- 慢性充血性心力衰竭 /
- 中性粒细胞明胶酶相关脂质运载蛋白 /
- N-末端B型脑钠肽前体 /
- 肾功能损伤
Abstract: Objective: To observe the changes of concentrations of NGAL and NT-proBNP in patients with chronic heart failure and investigate the relationship between these two testing items.Method: The clinical data of 97 patients with CHF were retrospectively analyzed. A total of 50 patients in the same age were selected as health control group who did health examination. Plasma NGAL, NT-proBNP levels, BUN, Cr, eGFR and LVEF were compared between study group and control group using statistical analysis, P<0.05 means the difference is statistical significant.Result: Serum NGAL, NT-proBNP, BUN and Cr levels were higher in patients with CHF than control group(P<0.05), while eGFR and LVEFwere lower in study group than control group(P<0.05). Analysis of variance of blood NGAL level and NT-proBNP level in each group were NYHA-Ⅳ grade> NYHA-Ⅲ grade> NYHA-Ⅱ grade> NYHA-Ⅰgrade, there was statistically significant difference at all levels. Serum NGAL levels were positively related to NT-proBNP (r=0.79, P<0.05) and LVEF levels were negatively related to NGAL and NT-proBNP(r=-0.36, P<0.05;r=-0.39, P<0.05).Conclusion: The development of heart failure and renal injury was closely related to the increase of NGAL and NT-proBNP levels in CHF patients.
- chronic heart failure /
- neutrophil gelatinase associated lipocalin /
- N-terminal pro-B-type natriuretic peptide /
- renal injury

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