心力衰竭患者循环Irisin水平与心功能的相关性研究

莫显刚; 冯健; 张莉; 江凤; 向凝; 郑淑展; 杨涓; 罗兴梅; 张洛超; 王龙

doi:10.13201/j.issn.1001-1439.2015.08.015

心力衰竭患者循环Irisin水平与心功能的相关性研究

- 1. 贵州医科大学附属医院老年病科(贵阳, 550004);
- 2. 四川医科大学第一附属医院心内科
基金项目:
国家自然科学基金（No：31260250，31300946）

详细信息

通讯作者: 莫显刚,E-mail:moxiangang123@126.com

中图分类号: R541.6

收稿日期: 2014-12-03

修回日期: 2015-01-14

Circulating irisin level and its correlation with heart function in patients with heart failure

- 1. Department of geriatrics, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China;
- 2. Department of cardiology, The First Affiliated Hospital of Sichuan Medical University

More Information

Corresponding author: MO Xiangang, E-mail: moxiangang123@126.com

Received Date: 03 December 2014

Revised Date: 14 January 2015

摘要

摘要: 目的：探讨心力衰竭（心衰）患者循环irisin水平与心功能是否存在相关性。方法：选取非糖尿病性扩张型心肌病住院患者46例作为心衰组和同期体检中心健康体检者23例为对照组。所有受试者均接受体格检查、生化指标、心脏超声和血清irisin水平检测。采用Student-t检验、Pearson相关分析和多元线性回归进行统计学分析。结果：心衰组血清irisin浓度[（76.39 ±20.34） ng/ml明显低于对照组（106.26±22.39） ng/ml （F=0.233，P<0.01）]；经Pearson相关分析示，血清irisin浓度与肌酐（Cr）、稳态胰岛素评估模型胰岛素抵抗（HOMA-IR）、左室舒张末内径（LVED）及NYHA （纽约心脏学会）心功能分级呈负相关（r=-0.246，-0.694，-0.577，-0.485；P<0.05），与左室射血分数（LVEF）、甘油三酯（TG）及高密度脂蛋白胆固醇（HDL）呈正相关（r=0.715，0.292，0.262；P<0.05）；多元线性回归分析发现，在排除Cr、HOMA-IR、LVED、NYHA心功能分级、HDL及TG后，血清irisin水平与LVEF呈显著负相关，LVEF是血清irisin水平独立影响因子（标准化回归系数=0.495，P<0.01）。结论：心衰患者循环irisin水平降低，可能参与心衰的糖脂代谢紊乱。
- irisin /
- 心力衰竭 /
- 扩张型心肌病 /
- 胰岛素抵抗
Abstract: Objective: To investigate the association between serum irisin and heart function in patients with heart failure.Method: Forty six non-diabetic subjects(29 males and 17 females) with dilated cardiomyopathy were selected from inpatients as heart failure group, and 23 control subjects(13 males and 10 females) were selected from healthy people in medical examination center as normal control group.Anthropometric indexes, biochemical and heart function parameters, and serum irisin 1evels were measured in all subjects.The data were analyzed using student-t test, Pearson correlation analysis and multiple linear regression analysis.Result: Serum irisin levels were significantly decreased in heart failure group compared with control group[(106.26±22.39) vs (76.39 ±20.34)ng/ml, P<0.01].Pearson correlation analysis showed that serum irisin levels in heart failure group were negatively associated with CR, HOMA-IR, LVED and NYHA grades(r=-0.246, -0.694, -0.577, -0.485;P<0.05), but were positively associated with LVEF, HDL and TG(r=0.715, 0.292, 0.262;P<0.05).Multiple linear regression analysis showed that after adjustment for SCr, IR, LVED, NYHA grade, HDL and TG, LVEF was the independent negative determinant of serum irisin (standardized regression coefficien t=0.495, P<0.01).Conclusion: Serum irisin 1evels are lower in non-diabetic patients with heart failure and LVEF is an independent predictor of circulating irisin, implying that irisin might participate in glucolipid metabolism dysfunction and development of heart failure.
- irisin /
- heart failure /
- dilated cardiomyopathy /
- insulin resistance

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