急性心肌梗死后不同时点血浆NT-proBNP水平与左心室重构相关性的比较

孙亚武; 陆曙

doi:10.13201/j.issn.1001-1439.2015.12.011

急性心肌梗死后不同时点血浆NT-proBNP水平与左心室重构相关性的比较

孙亚武^,,
陆曙

- 太仓市第一人民医院心内科(江苏太仓, 215400)

详细信息

通讯作者: 孙亚武,E-mail:syw0128@163.com

中图分类号: R541.4

收稿日期: 2015-04-27

Correlations between plasma NT-proBNP levels and left ventricular remodeling at different times after AMI

SUN Yawu^,,
LU Shu

- Department of Cardiology, The First People's Hospital of Taicang, Taicang, Jiangsu, 215400, China

More Information

Corresponding author: SUN Yawu, E-mail: syw0128@163.com

Received Date: 27 April 2015

摘要

摘要: 目的:通过比较急性心肌梗死(AMI)患者发病后不同时点血浆N端脑钠肽前体(NT-proBNP)水平与发病6个月后左室舒张末期内径(LVDd)、左心室射血分数(LVEF)的相关性,探讨不同时点血浆NT-proBNP水平对AMI发病后左心室重构预测价值的差别。方法:NT-proBNP检测试剂盒检测116例AMI患者发病后12、24、36 h血浆NT-proBNP水平,并随访患者发病6个月后LVDd、LVEF。结果:发病后12、24、36 h血浆NT-proBNP水平与6个后月后LVDd的相关系数分别为0.52、0.78、0.64,与LVEF的相关系数分别为-0.47、-0.81、-0.51(均P<0.05)。其中24 h的相关系数与12及36 h的比较差异有统计学意义(P<0.05)。结论:与发病后12、36 h相比较,发病后24 h的血浆NT-proBNP水平可以更好预测AMI发病6个月后的左心室重构。
- 急性心肌梗死 /
- N端脑钠肽前体 /
- 心室重构
Abstract: Objective: To investigate the correlations between plasma NT-proBNP levels at different times after AMI and left ventricular diastolic final diameter (LVDd), left ventricular ejection fraction (LVEF) after six months. Method: Plasma NT-proBNP of the 116 patients with AMI were detected by NT-proBNP assay kit at 12, 24 and 36 hours after AMI. LVDd and LVEF were detected by echocardiographic after six months.Result: The correlation coefficients between plasma NT-proBNP levels at 12, 24, 36 hours and LVDd were 0.52, 0.78, 0.64, and LVEF were -0.47,-0.81, -0.51 (all P<0.05). Compared with the other two groups, the correlation coefficient was the highest at 24 hours (P<0.05). Conclusion: In comparison to NT-proBNP levels at 12 and 36 hours after AMI occurrence, the NT-proBNP levels at 24 hours can better predict the left ventricular remodeling 6 month after AMI.
- acute myocardial infarction /
- NT-proBNP /
- ventricular remodeling

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参考文献(4)

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