将内皮祖细胞纳入心血管疾病治疗方案的争论与探讨

徐倩; 曹荟哲; 哈小琴

doi:10.13201/j.issn.1001-1439.2016.10.020

将内皮祖细胞纳入心血管疾病治疗方案的争论与探讨

- 1 兰州大学第二附属医院(兰州, 730030);
- 2 兰州理工大学;
- 3 兰州军区兰州总医院检验科
基金项目:
甘肃省自然基金项目(No:1107RJ2A114)

详细信息

通讯作者: 哈小琴,E-mail:haxiaoqin2013@163.com

中图分类号: R3

收稿日期: 2016-03-19

修回日期: 2014-07-04

The debate and discussion on taking the endothelial progenitor cells as cardiovascular disease treatment

- 1 The Second Hospital, Lanzhou University, Lanzhou, 730030, China;
- 2 Lanzhou University of Technology;
- 3 Department of Clinical Laboratory, Lanzhou General Hospital of Lanzhou Military Area Command

More Information

Corresponding author: HA Xiaoqin, E-mail: haxiaoqin2013@163.com

Received Date: 19 March 2016

Revised Date: 04 July 2014

摘要

摘要: 内皮祖细胞(EPCs)对受损血管的修复和新血管的形成至关重要。机体缺血或血管损伤时,EPCs可直接分化为成熟的内皮细胞(ECs)或分泌多种细胞因子促进血管的修复和新生。心血管疾病(CVD)的发生与体内EPCs的数量和功能密切相关,有建议认为可将其作为CVD的临床生物标志物。然而,目前关于EPCs的定义及其鉴定方法尚未标准化,因此关于将其作为CVD标志物值得探讨。
- 内皮祖细胞 /
- 内皮细胞 /
- 心血管疾病 /
- 血管损伤
Abstract: Endothelial progenitor cells(EPCs)play a key role in vascular impairment and neovascularization.EPCs differentiate into mature endothelial cells(ECs)or secreting cytokines to promote vascular self-repair and angiogenesis.There are increasing researches demonstrate that the quantities and function of EPCs have a close relationship with cardiovascular diseases(CVD)and suggest EPCs as the CVD's potential clinical biomarker.However,people still have controversies about it for lacking Standardized definition and identification of EPCs.
- endothelial progenitor cells /
- endothelial cells /
- cardiovascular diseases /
- vascular injury

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